NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice

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NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022773577
P356DOI10.1038/SJ.NPP.1300855
P698PubMed publication ID16123759
P5875ResearchGate publication ID7636463

P50authorQing-Rong LiuQ41050427
Frank Scott HallQ59550582
P2093author name stringTakeshi Sakurai
George R Uhl
Hiroshi Ujike
Martin Grumet
Hiroki Ishiguro
Jian-Ping Gong
Marisela Morales
P2860cites workPolysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphismsQ24535898
Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preferenceQ24603526
Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase betaQ24683911
Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalizationQ27863662
Nr-CAM: a cell adhesion molecule with ligand and receptor functionsQ28250450
Alternative splicing of human NrCAM in neural and nonneural tissuesQ28272120
Mutation screening and association analysis of six candidate genes for autism on chromosome 7qQ28291465
KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphineQ28509333
Substance abuse vulnerability loci: converging genome scanning dataQ30707290
Use of gene networks from full genome microarray libraries to identify functionally relevant drug-affected genes and gene regulation cascadesQ30916119
Convergent functional genomics: application to bipolar disorderQ34281200
A twin-family study of alcoholism in womenQ34340077
Assessment of cannabinoid induced gene changes: tolerance and neuroprotection.Q35035875
Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan resultsQ35948504
Genetic analyses of complex behavioral disordersQ36150426
rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitizationQ38344062
Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell lineQ38357673
Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilitiesQ42686475
Ethanol-regulated gene expression of neuroendocrine specific protein in mice: brain region and genotype specificityQ43562337
Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's diseaseQ44048965
Mouse brain gene expression changes after acute and chronic amphetamineQ44297184
mu-Opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine-induced locomotion.Q44344541
Psychopathology and temperament in parents and offspring: results of a family studyQ44471445
The assessment of dependence in the study of stressful life events: validation using a twin designQ44867120
Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twinsQ44869447
Cannabis use, abuse, and dependence in a population-based sample of female twinsQ45113019
The 5-HT3 receptor is present in different subpopulations of GABAergic neurons in the rat telencephalon.Q46072552
mu Opiate receptor immunoreactivity in rat central nervous systemQ48873819
D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant-preferring polysubstance abusersQ48889812
PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine.Q51608651
Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I B1 restriction fragment length polymorphism appears more frequently in polysubstance abusers.Q52264963
A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence.Q52285242
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population.Q54136978
Genetic and environmental influences on transitions in drug useQ57400510
A twin study of non-alcohol substance abuseQ71764648
A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA)Q71841576
Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathwayQ73514875
A twin study of drinking and smoking onset and latencies from first use to regular useQ73903435
Genome-wide search for genes affecting the risk for alcohol dependenceQ74594088
Molecular genetics of substance abuse vulnerability: a current approachQ77786003
Common genetic vulnerability for nicotine and alcohol dependence in menQ77987975
Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptomsQ77990991
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
P304page(s)572-84
P577publication date2006-03-01
P1433published inNeuropsychopharmacologyQ2261280
P1476titleNrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice
P478volume31

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cites work (P2860)
Q27311246Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models
Q36463511Association of the Neuronal Cell Adhesion Molecule (NrCAM) Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder
Q30494693Behavioral genetic contributions to the study of addiction-related amphetamine effects
Q36999713Candidate gene polymorphisms predicting individual sensitivity to opioids
Q48399038Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
Q37379509Cell adhesion molecules: druggable targets for modulating the connectome and brain disorders?
Q57805523Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist
Q91069635Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome
Q36352038Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
Q39052223Glutamate and Brain Glutaminases in Drug Addiction.
Q36042505Human cell adhesion molecules: annotated functional subtypes and overrepresentation of addiction-associated genes
Q30478179Impaired sociability and cognitive function in Nrcam-null mice
Q37320742Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects
Q36525149Molecular genetics of addiction vulnerability
Q36211831Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels
Q36568276Mouse model for PTPRD associations with WED/RLS and addiction: reduced expression alters locomotion, sleep behaviors and cocaine-conditioned place preference
Q35858745Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations
Q30387196Neural cell adhesion molecule NrCAM is expressed in the mammalian inner ear and modulates spiral ganglion neurite outgrowth in an in vitro alternate choice assay
Q35210793Neural integrity is maintained by dystrophin in C. elegans
Q34679766Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms
Q34984178Neuron glia-related cell adhesion molecule (NrCAM) promotes topographic retinocollicular mapping
Q90484251Neuronal cell adhesion molecule regulating neural systems underlying addiction
Q89477351Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors
Q34568049NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity
Q30525650NrCAM-regulating neural systems and addiction-related behaviors.
Q33328806Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction
Q37579911Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism
Q34059030Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk
Q33633457Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes
Q37059772Signals from the Fourth Dimension Regulate Drug Relapse
Q40078794Single cell adhesion measuring apparatus (SCAMA): application to cancer cell lines of different metastatic potential and voltage-gated Na+ channel expression
Q52318141The Role of Cell Adhesion Molecule Genes Regulating Neuroplasticity in Addiction.
Q38586140The influence of genes on "positive valence systems" constructs: A systematic review.
Q30313611Xenopus laevis neuronal cell adhesion molecule (nrcam): plasticity of a CAM in the developing nervous system.