A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography

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A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography is …
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scholarly articleQ13442814

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P356DOI10.1002/ANA.410150302
P698PubMed publication ID6609679
P5875ResearchGate publication ID227691778

P50authorMarcus E. RaichleQ6758402
Mark A. MintunQ43463865
P2093author name stringG F Wooten
M R Kilbourn
M J Welch
P2860cites workEvidence of the limitations of water as a freely diffusible tracer in brain of the rhesus monkeyQ48526800
Quantitative regional determination of morphometric indices of the total and perfused capillary network in the rat brainQ48889600
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpositron emission tomographyQ208376
P304page(s)217-27
P577publication date1984-03-01
P1433published inAnnals of NeurologyQ564414
P1476titleA quantitative model for the in vivo assessment of drug binding sites with positron emission tomography
P478volume15

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cites work (P2860)
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Q60618609PET imaging of garbage protein in Alzheimer’s disease: does it require reappraisal of brain PET analysis?
Q37695347PET imaging of ischemia-induced impairment of mitochondrial complex I function in monkey brain.
Q48320138PET measurement of serotonin transporter occupancy: a comparison of escitalopram and citalopram
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Q68427183PET studies of dopamine receptor distribution using [18F]fluoroethylspiperone: findings in disorders related to the dopaminergic system
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Q34589414Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
Q30419672Postpartum and depression status are associated with lower [[¹¹C]raclopride BP(ND) in reproductive-age women
Q48767945Preclinical evaluation of [123I]R93274 as a SPECT radiotracer for imaging 5-HT2A receptors
Q43972774Prefrontal dopamine D1 receptors and working memory in schizophrenia.
Q51431445Presynaptic and postsynaptic dopaminergic binding densities in the nigrostriatal and mesocortical systems in early Parkinson's disease: a double-tracer positron emission tomography study.
Q35692936Principles of tracer kinetic analysis
Q48487572Progressive supranuclear palsy: loss of striatal dopamine receptors demonstrated in vivo by positron tomography
Q36445693Psychosis and positron tomography
Q48769578Quantification of Human Opiate Receptor Concentration and Affinity Using High and Low Specific Activity [11C]Diprenorphine and Positron Emission Tomography
Q48363610Quantification of Neuroreceptors in the living human brain. II. Inhibition studies of receptor density and affinity
Q48516606Quantification of PET studies with the very high-affinity dopamine D2/D3 receptor ligand [11C]FLB 457: re-evaluation of the validity of using a cerebellar reference region
Q70168714Quantification of baboon cortical S2 serotonin receptors in vivo with 3-N-(2'-F18)fluoroethylspiperone and positron emission tomography
Q52880636Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol.
Q44848584Quantification of cerebral A1 adenosine receptors in humans using [18F]CPFPX and PET.
Q48159280Quantification of cerebral nicotinic acetylcholine receptors by PET using 2-[18F]fluoro-A-85380 and the multiinjection approach
Q44352755Quantification of delta-opioid receptors in human brain with N1'-([11C]methyl) naltrindole and positron emission tomography
Q47976364Quantification of muscarinic cholinergic receptors with [11C]NMPB and positron emission tomography: method development and differentiation of tracer delivery from receptor binding
Q41874977Quantification of neuroreceptors in the living human brain. I. Irreversible binding of ligands
Q41878571Quantifying receptor density in vivo using a dual-probe approach with fluorescence molecular imaging
Q48212090Quantitation of extrastriatal D2 receptors using a very high-affinity ligand (FLB 457) and the multi-injection approach
Q35208026Quantitation of translocator protein binding in human brain with the novel radioligand [18F]-FEPPA and positron emission tomography
Q48152969Quantitative PET imaging of radioligands with slow kinetics in human brain.
Q46973688Quantitative analyses of regional [11C]PE2I binding to the dopamine transporter in the human brain: a PET study
Q43937499Quantitative analysis for estimating binding potential of the brain serotonin transporter with [11 C]McN5652.
Q48548547Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106.
Q41854612Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain
Q59845518Quantitative analysis of [carbonyl-11C]WAY-100635 PET studies
Q44886310Quantitative analysis of dopamine D2 receptor kinetics with small animal positron emission tomography
Q27023605Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging
Q37551473Quantitative in vivo receptor binding III: Tracer kinetic modeling of muscarinic cholinergic receptor binding
Q48710535Radiation dosimetry of [18F] (N-methyl)benperidol as determined by whole-body PET imaging of primates.
Q39833273Radioactive oxygen-15 in the study of cerebral blood flow, blood volume, and oxygen metabolism
Q38859451Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-{[(4-methoxyphenyl)carbamoyl]amino}-N-{[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl}propanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neu
Q34468544Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters
Q38254737Recent advances in parametric neuroreceptor mapping with dynamic PET: basic concepts and graphical analyses
Q35024111Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
Q48338717Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography
Q48205757Reduced midbrain-pons serotonin transporter binding in patients with obsessive-compulsive disorder
Q43248340Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results.
Q48705214Regional brain measurement of Bmax and KD with the opiate antagonist cyclofoxy: equilibrium studies in the conscious rat.
Q40445138Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography
Q69826129Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET
Q90732288Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake
Q37252773Relationship of the serotonin transporter gene promoter polymorphism (5-HTTLPR) genotype and serotonin transporter binding to neural processing of negative emotional stimuli
Q43577897Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and.
Q51072080Robust experiment design for estimating myocardial beta adrenergic receptor concentration using PET.
Q40139168Role of Kinetic Modeling in Biomedical Imaging
Q48127572SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: I. Kinetic modeling of single bolus experiments
Q72376577SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates: II. Equilibrium analysis of constant infusion experiments and correlation with in vitro parameters
Q48616535Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology
Q42178045Selection of weighting factors for quantification of PET radioligand binding using simplified reference tissue models with noisy input functions
Q46562388Sequential versus nonsequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: 2: effects of DAT inhibitors
Q44685274Sequential versus nonsequential measurement of density and affinity of dopamine D2 receptors with [11C]raclopride: effect of methamphetamine
Q48428891Serotonin 1A receptor availability in patients with schizophrenia and schizo-affective disorder: a positron emission tomography imaging study with [11C]WAY 100635.
Q36696405Serotonin 1A receptor reductions in postpartum depression: a positron emission tomography study
Q37633750Serotonin 2A receptors in obsessive-compulsive disorder: a positron emission tomography study with [11C]MDL 100907.
Q73997912Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography
Q34305236Serotonin 5HT2 receptor imaging in the human brain using positron emission tomography and a new radioligand, [18F]altanserin: results in young normal controls
Q40012224Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans
Q43700709Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers.
Q50131292Similarity and robustness of PET and SPECT binding parameters for benzodiazepine receptors
Q42414714Simultaneous estimation of input functions: an empirical study.
Q37632839Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys
Q27309046Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease
Q42106007Social change and access to a palatable diet produces differences in reward neurochemistry and appetite in female monkeys
Q46447581Specific binding of [3H]pyrilamine to histamine H1 receptors in guinea pig brain in vivo: determination of binding parameters by a kinetic four-compartment model.
Q52306514Stereotaxic summation analysis of human cerebral benzodiazepine binding maps.
Q48361734Strategies for in vivo measurement of receptor binding using positron emission tomography
Q72635469Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence
Q28551943Striatal Dopamine D2/D3 Receptor Availability Is Associated with Executive Function in Healthy Controls but Not Methamphetamine Users
Q47778325Striatal dopamine D2/3 receptor-mediated neurotransmission in major depression: Implications for anhedonia, anxiety and treatment response
Q33656355Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
Q73222431Striatal dopaminergic transmission and neocortical glucose utilization in Alzheimer's disease: a triple-tracer positron emission tomography study
Q48080738Suicidal ideation modulates the reduction in serotonin transporter availability in male military conscripts with major depression: A 4-[18F]-ADAM PET study
Q44648588Suitability of [18F]altanserin and PET to determine 5-HT2A receptor availability in the rat brain: in vivo and in vitro validation of invasive and non-invasive kinetic models
Q41135661Swim stress alters in vivo binding of [3H]N-methylspiperone
Q37286420Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography
Q38828768Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF
Q38984519Tactics for preclinical validation of receptor-binding radiotracers
Q37925864Technical aspects of amyloid imaging for Alzheimer's disease
Q52211022Temperature effect on serum protein binding kinetics of phenytoin in monotherapy patients with epilepsy.
Q48301045Test-retest stability of cerebral A1 adenosine receptor quantification using [18F]CPFPX and PET.
Q33478744Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults
Q48698421The Visualization of Neuronal Benzodiazepine Receptors in the Brain by Autoradiography and Immunohistochemistry
Q55332403The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Q37500893The dopaminergic basis of human behaviors: A review of molecular imaging studies
Q46984899The effect of antiepileptic drugs on 5-HT-receptor binding measured by positron emission tomography
Q36094332The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
Q36482672The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis
Q36677808The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging
Q34343170The physical chemistry of ligand-receptor binding identifies some limitations to the analysis of receptor images
Q23992160The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study
Q48902212The quantitative analysis of D2-dopamine receptors in baboon striatum in vivo with 3-N-[2'-18F]fluoroethylspiperone using positron emission tomography
Q34088959The role of model-based methods in the development of single scan techniques
Q41676775The role of positron emission tomography in pharmacokinetic analysis
Q28727519The role of serotonin in sleep disordered breathing associated with Parkinson disease: a correlative [11C]DASB PET imaging study
Q40515066The simplified reference tissue model: model assumption violations and their impact on binding potential.
Q47254408The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases.
Q48143122Theoretical effects of radioligand diffusional gradients and microscopic neuroreceptor distribution in in vivo kinetic studies
Q21136367Thinking outside a less intact box: thalamic dopamine D2 receptor densities are negatively related to psychometric creativity in healthy individuals
Q37369444Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
Q35049632Tomography of epidermal growth factor receptor binding to fluorescent Affibody in vivo studied with magnetic resonance guided fluorescence recovery in varying orthotopic glioma sizes.
Q64080667Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography
Q37635268Unexpectedly high affinity of a novel histamine H(3) receptor antagonist, GSK239512, in vivo in human brain, determined using PET.
Q48404399Uptake and utilization of [beta-11C] 5-hydroxytryptophan in human brain studied by positron emission tomography
Q34040435Use of Positron Emission Tomography to Measure Brain Activity Responses to Fentanyl Analgesia
Q36215997Uses and Limitations of Positron Emission Tomography in Clinical Pharmacokinetics/Dynamics (Part II)
Q36026695Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
Q52923973Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-11C]WAY-100635 in humans: comparison of arterial and reference tisssue input functions.
Q48548536Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907.
Q36666227Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans
Q50985041Validity of model approximations for receptor-ligand kinetics in nuclear medicine.
Q49056581Vesicular monoamine transporter concentrations in bipolar disorder type I, schizophrenia, and healthy subjects
Q48316857Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis
Q48772014Visualization and quantification of neurokinin-1 (NK1) receptors in the human brain
Q31911300[(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites
Q33954169[(11)]Cocaine: PET studies of cocaine pharmacokinetics, dopamine transporter availability and dopamine transporter occupancy
Q28731698[11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels
Q48198612[11C]tropanyl benzilate-binding to muscarinic cholinergic receptors: methodology and kinetic modeling alternatives
Q32144136[123I] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa
Q48326056[123I]-beta-CIT SPECT imaging shows reduced thalamus-hypothalamus serotonin transporter availability in 24 drug-free obsessive-compulsive checkers
Q53440586[18F]fallypride-PET/CT Analysis of the Dopamine D₂/D₃ Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection.