Vascular calcification: pathobiology of a multifaceted disease

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Vascular calcification: pathobiology of a multifaceted disease is …
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P356DOI10.1161/CIRCULATIONAHA.107.743161
P3181OpenCitations bibliographic resource ID644982
P932PMC publication ID4431628
P698PubMed publication ID18519861

P50authorLinda L DemerQ42562196
P2093author name stringYin Tintut
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Differential expression of bone matrix regulatory proteins in human atherosclerotic plaquesQ77350558
High coronary artery calcium scores pose an extremely elevated risk for hard eventsQ77480610
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Identification and characterization of calcifying valve cells from human and canine aortic valvesQ77982316
Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiolQ78004667
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High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cellsQ79148900
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Uremia-related vascular calcification: more than apatite depositionQ79408629
Vascular calcification: not so crystal clearQ79744868
Presence of abdominal aortic calcification is significantly associated with all-cause and cardiovascular mortality in maintenance hemodialysis patientsQ79870466
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- miceQ79903873
Role of fibroblast growth factor-23 in peripheral vascular calcification in non-diabetic and diabetic hemodialysis patientsQ80078924
Vascular calcification: contribution of parathyroid hormone in renal failureQ80101278
The relation between mitral annular calcification and mortality in patients undergoing diagnostic coronary angiographyQ80339517
Coronary calcification improves cardiovascular risk prediction in the elderlyQ80357431
Endochondral bone formation is involved in media calcification in rats and in menQ80406983
Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosisQ80413873
Role of osteoprotegerin in arterial calcification: development of new animal modelQ80576674
Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndromeQ81470493
Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitroQ81632097
Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cellsQ81676413
Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathwayQ82928082
Pathology of the vulnerable plaqueQ83187650
Matrix metalloproteinase inhibition attenuates aortic calcificationQ83323452
Msx2 promotes cardiovascular calcification by activating paracrine Wnt signalsQ42717983
Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorptionQ43604722
Prevalence and correlates of coronary calcification in black and white young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.Q43604734
Patterns and risk factors for systemic calcified atherosclerosisQ43690938
Oxidative stress modulates osteoblastic differentiation of vascular and bone cellsQ43702897
Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D.Q43764592
Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers.Q43819702
Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular diseaseQ43865169
Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cellsQ44173368
Osteopontin Deficiency Attenuates Atherosclerosis in Female Apolipoprotein E–Deficient MiceQ44429147
Cartilaginous metaplasia in calcified diabetic peripheral vascular disease: Morphologic evidence of enchondral ossificationQ44431335
Osteoprotegerin Regulates Bone Formation through a Coupling Mechanism with Bone ResorptionQ44590734
Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient miceQ44592811
Prediction of coronary events with electron beam computed tomographyQ44627202
Serum Levels of the Fetuin-Mineral Complex Correlate with Artery Calcification in the RatQ44631933
Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivoQ44690058
Bone morphogenic protein-4 expression in vascular lesions of calciphylaxis.Q44734905
Arterial calcifications and bone histomorphometry in end-stage renal diseaseQ44949005
Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD.Q45124317
Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcificationQ45200610
Coronary artery and abdominal aortic calcification are associated with cardiovascular disease in type 2 diabetesQ45249096
N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways.Q45935973
Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients.Q45946808
cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification.Q45996887
Monocyte/macrophage regulation of vascular calcification in vitroQ46083654
Chondrogenesis mediated by PPi depletion promotes spontaneous aortic calcification in NPP1-/- miceQ46197496
A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosisQ46535596
Genetic determination of cartilaginous metaplasia in mouse aorta.Q46608623
Connections between vascular calcification and progression of chronic kidney disease: therapeutic alternativesQ46841631
Effect of intensive versus standard lipid-lowering treatment with atorvastatin on the progression of calcified coronary atherosclerosis over 12 months: a multicenter, randomized, double-blind trialQ46895799
A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J miceQ46951764
Reversibility of calcitriol-induced medial artery calcification in rats with intact renal functionQ46954793
Phosphate-induced vascular calcification: role of pyrophosphate and osteopontinQ47578435
Involvement of matrix metalloproteinases and tenascin-C in elastin calcificationQ47773556
Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?Q50684275
Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells.Q50707613
Chondrogenic and adipogenic potential of microvascular pericytes.Q50784818
Lower-extremity amputations in NIDDM. 12-yr follow-up study in Pima Indians.Q51626934
The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues.Q52119912
Aortic calcification in haemodialysis patients with diabetes mellitus.Q53575137
Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul StudyQ31111874
Natural history and topographic pattern of progression of coronary calcification in symptomatic patients: An electron-beam CT studyQ32085711
Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factorsQ33182532
Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcificationQ33291152
Vascular smooth muscle and arterial calcificationQ33894026
TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.Q34145009
Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcificationQ34217171
Oral anticoagulant treatment: friend or foe in cardiovascular disease?Q34334786
Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound studyQ34370169
Calcification of vascular smooth muscle cell cultures: inhibition by osteopontinQ34491036
A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous capsQ35075416
Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responsesQ35087914
Angiogenesis and marrow stromal cell fates: roles in bone strengthQ35541093
T lymphocyte infiltration in non-rheumatic aortic stenosis: a comparative descriptive study between tricuspid and bicuspid aortic valvesQ35580436
Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valveQ35584233
BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cellsQ35643930
Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis)Q35754273
Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcificationQ35833202
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisQ36368706
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivoQ36371196
Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more).Q36482441
Mechanisms of vascular calcificationQ36697880
The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasisQ36860289
Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular diseaseQ36918536
Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) mice.Q37188485
Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgeneQ37265676
Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formationQ37633944
High-density lipoprotein regulates calcification of vascular cells.Q39265314
Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease.Q40251686
Bone morphogenetic protein expression in human atherosclerotic lesions.Q40304303
Oxidative stress, advanced glycation end product, and coronary artery calcification in hemodialysis patientsQ40322189
Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip.Q40324778
Multilineage potential of cells from the artery wall.Q40622386
Long-term prognostic value of coronary calcification detected by electron-beam computed tomography in patients undergoing coronary angiographyQ40695603
Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cellsQ40817294
The role of Gla proteins in vascular calcification.Q40836210
Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes mellitusQ40933115
Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricleQ41094750
THE FORMATION OF TRUE BONE WITH CELLULAR (RED) MARROW IN A SCLEROTIC AORTA.Q41910297
Human Aortic Valve Calcification Is Associated With an Osteoblast PhenotypeQ41950206
Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valvesQ42539622
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectvascular calcificationQ54911504
P304page(s)2938-48
P577publication date2008-06-03
P1433published inCirculationQ578091
P1476titleVascular calcification: pathobiology of a multifaceted disease
P478volume117