Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

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Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M610790200
P3181OpenCitations bibliographic resource ID4912450
P698PubMed publication ID17259171

P2093author name stringRobert H Tukey
Mei-Fei Yueh
P2860cites workInduction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap n collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2)Q23919661
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligaseQ24558689
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionQ24563505
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainQ24609907
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptorQ24683260
Human UDP-glucuronosyltransferases: metabolism, expression, and diseaseQ28145608
Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzymeQ28179772
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsQ28218883
Cloning and characterization of the 5'-flanking region of the rat glutamate-cysteine ligase catalytic subunitQ28343583
Nrf2 is essential for protection against acute pulmonary injury in miceQ28343659
Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: evidence for both genetic and environmental influencesQ28369688
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophagesQ29614557
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionQ29615644
Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesisQ33665840
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamilyQ34448366
Gene silencing in mammals by small interfering RNAsQ34931992
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2Q35814343
Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.Q35886045
Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.Q35974262
Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteinsQ36688599
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysisQ38358203
Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.Q40309310
The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1.Q40332798
The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target geneQ40671179
Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbonsQ41575145
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequenceQ42157111
Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinoneQ42523109
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.Q43601213
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaustQ43662015
Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathwayQ44253623
Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.Q44302135
Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptorQ44535717
Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compoundsQ44865415
Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.Q46140095
The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.Q54590328
Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting PQ56566940
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)8749-58
P577publication date2007-03-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleNrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice
P478volume282