Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases

scientific article

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases is …
instance of (P31):
scholarly articleQ13442814

External links are
P698PubMed publication ID3210246

P2093author name stringA Laudano
R Mattaliano
T Bestor
V Ingram
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)971-83
P577publication date1988-10-20
P1433published inJournal of Molecular BiologyQ925779
P1476titleCloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
P478volume203

Reverse relations

cites work (P2860)
Q3586523611q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene
Q340483125-Methyl-2'-deoxycytidine in single-stranded DNA can act in cis to signal de novo DNA methylation
Q36564819A 5' differentially methylated sequence and the 3'-flanking region are necessary for H19 transgene imprinting
Q80094274A DNA microarray-based methylation-sensitive (MS)-AFLP hybridization method for genetic and epigenetic analyses
Q36722013A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells
Q36718034A common mode of recognition for methylated CpG.
Q27023231A concise review on epigenetic regulation: insight into molecular mechanisms
Q34334819Above and within the genome: epigenetics past and present
Q28485716Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells
Q41529080Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain
Q34129576Active DNA demethylation: many roads lead to Rome.
Q27678170Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH
Q24310468Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
Q35875033Analysis of substrate specificity of the PaeR7 endonuclease: effect of base methylation on the kinetics of cleavage
Q36408191Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases
Q36746770Are there two DNA methyltransferase gene families in plant cells? A new potential methyltransferase gene isolated from an Arabidopsis thaliana genomic library
Q84279789Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma
Q36678669Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin
Q57810467BAH domains and a histone-like motif in DNA methyltransferase 1 (DNMT1) regulate de novo and maintenance methylation in vivo
Q34445121Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase
Q36891056Biological aspects of cytosine methylation in eukaryotic cells
Q24634671Biology of DNA restriction
Q37342459Biomarkers of chemotherapy-induced testicular damage
Q37248365Breast cancer epigenetics: normal human mammary epithelial cells as a model system
Q24680140CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1
Q37511752Cause and consequences of genetic and epigenetic alterations in human cancer.
Q38221517Causes and Consequences of Age-Related Changes in DNA Methylation: A Role for ROS?
Q37471107Changes in DNA methylation patterns and repetitive sequences in blood lymphocytes of aged horses.
Q37087464Characterization of How DNA Modifications Affect DNA Binding by C2H2 Zinc Finger Proteins.
Q34733991Characterization of an Arabidopsis thaliana DNA hypomethylation mutant
Q37067895Characterization of cytosine methylated regions and 5-cytosine DNA methyltransferase (Ehmeth) in the protozoan parasite Entamoeba histolytica
Q35244289Chronic virus infection enforces demethylation of the locus that encodes PD-1 in antigen-specific CD8(+) T cells.
Q40522304Cloning and nucleotide sequence of the genes coding for the Sau96I restriction and modification enzymes
Q40514685Cloning, characterization, and expression in Escherichia coli of the gene coding for the CpG DNA methylase from Spiroplasma sp. strain MQ1(M.SssI).
Q38926364Combined analysis of DNA methylation and cell cycle in cancer cells
Q40506903Complementation by detached parts of GGCC-specific DNA methyltransferases.
Q36685637Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene
Q35702821Conserved plant genes with similarity to mammalian de novo DNA methyltransferases.
Q33367193Coordinate suppression of mutations caused by Robertson's mutator transposons in maize
Q35186394Cytosine methylation and mammalian development
Q36724982DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases
Q90286328DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation
Q27680608DNA Recognition of 5-Carboxylcytosine by a Zfp57 Mutant at an Atomic Resolution of 0.97 Å
Q90250166DNA base flipping analytical pipeline
Q33642025DNA demethylation
Q49078217DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.
Q38561038DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.
Q42859700DNA methylase from Pisum sativum
Q37057353DNA methylation and gene expression
Q37197626DNA methylation is a reversible biological signal
Q39022593DNA methylation is dispensable for changes in global chromatin architecture but required for chromocentre formation in early stem cell differentiation.
Q34314397DNA methylation mediates the discriminatory power of associative long-term memory in honeybees
Q38140865DNA methylation. The effect of minor bases on DNA-protein interactions
Q34218919DNA methylation: superior or subordinate in the epigenetic hierarchy?
Q35673681DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation
Q34559675DNA methyltransferase 3b preferentially associates with condensed chromatin
Q36310752DNA methyltransferase is actively retained in the cytoplasm during early development
Q35070281DNA methyltransferase is developmentally expressed in replicating and non-replicating male germ cells
Q35544952DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population.
Q80231007DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer
Q36823294DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population
Q34632106DNMT1 maintains progenitor function in self-renewing somatic tissue
Q53089205DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.
Q36966957De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET.
Q36561731De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
Q33738027De novo methylation of the MyoD1 CpG island during the establishment of immortal cell lines
Q90381945Detecting and interpreting DNA methylation marks
Q38320032Determination of the order of substrate addition to MspI DNA methyltransferase using a novel mechanism-based inhibitor
Q35076369Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine
Q34631131Discovery of a bacterial 5-methylcytosine deaminase
Q27728003Distinctive Klf4 mutants determine preference for DNA methylation status
Q37371537Dnmt1 regulates the myogenic lineage specification of muscle stem cells
Q24534441Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
Q35724542Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases
Q89799606Dynamic evolution of de novo DNA methyltransferases in rodent and primate genomes
Q28681777Early origins of adult disease: approaches for investigating the programmable epigenome in humans, nonhuman primates, and rodents
Q35921364Effect of site-specific methylation on DNA modification methyltransferases and restriction endonucleases
Q34990892Effect of site-specific methylation on restriction endonucleases and DNA modification methyltransferases
Q34871498Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases
Q48372953Effects of transient cerebral ischemia on the expression of DNA methyltransferase 1 in the gerbil hippocampal CA1 region
Q35004935Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
Q37587846Environmental influences on epigenetic profiles.
Q24643547Environmental studies of schizophrenia through the prism of epigenetics
Q33741188Environmentally induced autoimmune diseases: potential mechanisms
Q38133731Epidermal stem cells and their epigenetic regulation
Q64998142Epigenetic Crosstalk between the Tumor Microenvironment and Ovarian Cancer Cells: A Therapeutic Road Less Traveled.
Q38107626Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation
Q36876483Epigenetic control of gonadotropin releasing hormone neurons
Q37148718Epigenetic mechanisms and therapeutic perspectives for neurodevelopmental disorders
Q38857804Epigenetic mechanisms regulating the development of hepatocellular carcinoma and their promise for therapeutics
Q33893082Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues
Q44829896Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells.
Q40579569Epigenetic modifications affect Dnmt3L expression
Q33931182Epigenetic modifications and canonical wingless/int-1 class (WNT) signaling enable trans-differentiation of nonosteogenic cells into osteoblasts
Q37041763Epigenetics and epigenetic alterations in pancreatic cancer.
Q28258498Epigenetics and its role in male infertility
Q36428883Epigenetics and the adaptive immune response
Q37469995Epigenetics: definition, mechanisms and clinical perspective.
Q25256980Epigenetics: environmental instructions for the genome
Q86589279Erratum to: Negative feedback of miR-29 family TET1 involves in hepatocellular cancer
Q35169651Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.
Q35418152Evolution of DNA methylation patterns in the Brassicaceae is driven by differences in genome organization
Q42778480Expression of DNA methyltransferases in adult dorsal root ganglia is cell-type specific and up regulated in a rodent model of neuropathic pain.
Q36559933Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Q26852086Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
Q40021115Frequent aberrant methylation of p16INK4a in primary rat lung tumors
Q28391482Genome-wide analysis in human colorectal cancer cells reveals ischemia-mediated expression of motility genes via DNA hypomethylation
Q37231658Genome-wide methylated CpG island profiles of melanoma cells reveal a melanoma coregulation network
Q40917469Genomic imprinting: implications for behavioral genetics
Q34819792Germ cell differentiation from pluripotent cells
Q24648996Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
Q33812858Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3
Q34356521Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes
Q37363149High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
Q37487997High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
Q84325850Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase
Q33732110Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters
Q40387475Hybrid mouse-prokaryotic DNA (cytosine-5) methyltransferases retain the specificity of the parental C-terminal domain
Q35727573Hydroxymethylation of DNA: an epigenetic marker
Q45767015Identification of the gene encoding the DNA (cytosine-5) methyltransferase of lymphocystis disease virus
Q33852775Imprinted genes as potential genetic and epigenetic toxicologic targets
Q35213638Imprinting errors and developmental asymmetry
Q24538381Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity
Q39716822In differentiating mouse myoblasts DNA methyltransferase is posttranscriptionally and posttranslationally regulated
Q35956336In vitro methylation of CpG-rich islands
Q35083484Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
Q37628234Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
Q47133300Independence between pre-mRNA splicing and DNA methylation in an isogenic minigene resource
Q52684665Independent functions of DNMT1 and USP7 at replication foci.
Q40543174Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma
Q33777676Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production
Q37457445Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes.
Q34676590Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development
Q35960841Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide
Q24806844Interactions within the mammalian DNA methyltransferase family
Q24605047Isolation and characterization of the cDNA encoding human DNA methyltransferase
Q38319075Isolation and identification by sequence homology of a putative cytosine methyltransferase from Arabidopsis thaliana
Q24540245Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes
Q52617363Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.
Q40806982McrB: a prokaryotic protein specifically recognizing DNA containing modified cytosine residues.
Q35832340Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis
Q26823896Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
Q33878027Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
Q33557545Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta
Q38934431Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype
Q28364163Methylation matters
Q39428859MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer
Q26742136Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease
Q34143019Molecular and Enzymatic Profiles of Mammalian DNA Methyltransferases: Structures and Targets for Drugs
Q33918801Molecular signatures of pancreatic cancer
Q47907020Multiple DNA methyltransferase genes in Arabidopsis thaliana
Q77471629Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro
Q24557458Myc represses transcription through recruitment of DNA methyltransferase corepressor
Q28817493N6-Methyladenine: A Conserved and Dynamic DNA Mark
Q53228628Negative feedback of miR-29 family TET1 involves in hepatocellular cancer.
Q37727692Nucleic acid oxidation in DNA damage repair and epigenetics
Q34111928Organization of restriction-modification systems
Q41879025Overproduction, purification and characterization of M.EcoHK31I, a bacterial methyltransferase with two polypeptides
Q35955186PTPRD silencing by DNA hypermethylation decreases insulin receptor signaling and leads to type 2 diabetes
Q73499740Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
Q30327264Plant DNA methyltransferases.
Q57478270Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism
Q37313424Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy
Q40448394Predictive motifs derived from cytosine methyltransferases
Q36701076Primary structure of the herpesvirus saimiri genome
Q41949687Prolonged Effects of Silver Nanoparticles on p53/p21 Pathway-Mediated Proliferation, DNA Damage Response, and Methylation Parameters in HT22 Hippocampal Neuronal Cells
Q37559797Protein expression, mRNA expression and gene amplification of DNA methyltransferase 1 in endometrial tumor tissues
Q36150047Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells
Q38945347Putting DNA methylation in context: from genomes to gene expression in plants
Q36181315Quantitative trait variation is revealed in a novel hypomethylated population of woodland strawberry (Fragaria vesca).
Q68262128Reactivation of a silent Ac following tissue culture is associated with heritable alterations in its methylation pattern
Q37771572Redefining regulation of DNA methylation by RNA interference
Q35119963Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo
Q37217178Regulation of CpG methylation by Dnmt and Tet in pluripotent stem cells
Q37126117Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells
Q24548607Regulation of X-chromosome inactivation in development in mice and humans
Q38641386Regulation of maintenance DNA methylation via histone ubiquitylation.
Q35084510Regulation of mammalian DNA methyltransferases: a route to new mechanisms
Q33763852Rethinking how DNA methylation patterns are maintained
Q38070800Roles of repressive epigenetic machinery in lineage decision of T cells
Q24338663SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
Q35008673Self-methylation of BspRI DNA-methyltransferase.
Q35229758Sequence, internal homology and high-level expression of the gene for a DNA-(cytosine N4)-methyltransferase, M.Pvu II.
Q35855268Site-specific methylation: effect on DNA modification methyltransferases and restriction endonucleases
Q74159164Specific induction of Z-DNA conformation by a nuclear localization signal peptide of lupin glutaminyl tRNA synthetase
Q35839835Statistical inference of in vivo properties of human DNA methyltransferases from double-stranded methylation patterns
Q27681691Structural basis for Klf4 recognition of methylated DNA
Q90637070Structural basis for effects of CpA modifications on C/EBPβ binding of DNA
Q27671003Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease
Q27684070Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA
Q36370892Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
Q34589795Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area
Q28505530Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog
Q36668364TET family proteins: oxidation activity, interacting molecules, and functions in diseases
Q36244447TET proteins and 5-methylcytosine oxidation in the immune system
Q42761123TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
Q33791229TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.
Q21284979Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries
Q35944741Tet family proteins and 5-hydroxymethylcytosine in development and disease
Q24614934The DNA (cytosine-5) methyltransferases
Q50192087The DNA Methylome of the Hyperthermoacidophilic Crenarchaeon Sulfolobus acidocaldarius
Q35085785The DNA methylome
Q50072002The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
Q36724810The Impact of DNA Methylation in Hematopoietic Malignancies
Q26824713The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations
Q26743549The Role of Mir-148a in Cancer
Q89985775The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme
Q90639977The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site
Q47136779The chemistries and consequences of DNA and RNA methylation and demethylation
Q26739014The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development
Q34734767The fission yeast gene pmt1+ encodes a DNA methyltransferase homologue
Q34549462The importance of epigenetic alterations in the development of epstein-barr virus-related lymphomas
Q34241071The marks, mechanisms and memory of epigenetic states in mammals
Q24536177The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity
Q38059664The role of DNA methylation and histone modifications in transcriptional regulation in humans.
Q39706045The small subunit of M. AquI is responsible for sequence-specific DNA recognition and binding in the absence of the catalytic domain
Q33843609Totipotency in the mouse.
Q26783490Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications
Q52643470Trans-differentiation via Epigenetics: A New Paradigm in the Bone Regeneration.
Q34041294Transgene silencing by the host genome defense: implications for the evolution of epigenetic control mechanisms in plants and vertebrates
Q35021889Twists and turns of DNA methylation
Q24655349Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues
Q36930456Viruses and viruslike particles of eukaryotic algae
Q28117086Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence
Q28345107dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in Neurospora
Q37745546miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1.
Q42361576rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline.

Search more.