Structure of human urokinase plasminogen activator in complex with its receptor

scientific article

Structure of human urokinase plasminogen activator in complex with its receptor is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2006Sci...311..656H
P356DOI10.1126/SCIENCE.1121143
P3181OpenCitations bibliographic resource ID649952
P698PubMed publication ID16456079

P50authorDouglas CinesQ16204220
P2093author name stringCai Yuan
David E Shaw
Liqing Chen
Mingdong Huang
Yongdong Li
Barbara C Furie
Bruce Furie
Andrew P Mazar
Qing Huai
Jennifer Callahan
Alice Kuo
Graham C Parry
Chuanbing Bian
P433issue5761
P407language of work or nameEnglishQ1860
P921main subjecturokinase plasminogen activator receptor activityQ14883151
plasminogenQ107129060
P304page(s)656-9
P577publication date2006-02-03
P1433published inScienceQ192864
P1476titleStructure of human urokinase plasminogen activator in complex with its receptor
P478volume311

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cites work (P2860)
Q38648131A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein-Protein Interaction Interfaces.
Q40105822A cleavage-resistant urokinase plasminogen activator receptor exhibits dysregulated cell-surface clearance
Q39999171A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor
Q80027715A direct link between expression of urokinase plasminogen activator receptor, growth rate and oncogenic transformation in mouse embryonic fibroblasts
Q36298409A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)
Q35559411A new class of orthosteric uPAR·uPA small-molecule antagonists are allosteric inhibitors of the uPAR·vitronectin interaction
Q37695404A novel tumor targeting drug carrier for optical imaging and therapy
Q40302526A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth
Q43264829Accelerated thrombus lysis in the blood of plasminogen activator inhibitor deficient mice is inhibited by PAI-1 with a very long half-life
Q52768529Acute effects of moderate altitude on biomarkers of cardiovascular inflammation and endothelial function and their differential modulation by dual endothelin receptor blockade.
Q39574481Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein-protein binding free energies and re-rank binding poses generated by protein-protein docking
Q89736584Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials
Q38669149Biophysical Mechanisms Mediating Fibrin Fiber Lysis.
Q44256854Cardiovascular Disease Biomarkers and suPAR in Predicting Decline in Renal Function: A Prospective Cohort Study.
Q41908264Challenges for drug discovery - a case study of urokinase receptor inhibition
Q83282038Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking
Q35312973Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.
Q45106348Conserved structural determinants in three-fingered protein domains
Q90092778Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain
Q27650194Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Q52709764Current advances in circulating inflammatory biomarkers in atherosclerosis and related cardio-cerebrovascular diseases.
Q37203518DOT corrected fluorescence molecular tomography using targeted contrast agents for small animal tumor imaging
Q62813888Diagnostic Value of Soluble Urokinase-Type Plasminogen Activator Receptor in Addition to High-Sensitivity Troponin I in Early Diagnosis of Acute Myocardial Infarction.
Q92510521Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?
Q37093692Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2
Q36010344Dual actions of albumin packaging and tumor targeting enhance the antitumor efficacy and reduce the cardiotoxicity of doxorubicin in vivo
Q44008835Effect of surface charge and ligand organization on the specific cell-uptake of uPAR-targeted nanoparticles
Q38245545Effects of allopurinol on exercise-induced muscle damage: new therapeutic approaches?
Q83822363Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia
Q24336025Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR
Q35440794Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis
Q35151053Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study
Q27681464Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b (αM)
Q38111811Impact of expression of the uPA system in sarcomas
Q57563925Increased plasma level of soluble urokinase plasminogen activator receptor is associated with incidence of heart failure but not atrial fibrillation
Q38912052Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance
Q38297320Lanthanide-doped luminescent nano-bioprobes for the detection of tumor markers.
Q39506373Lanthanide-doped luminescent nano-bioprobes: from fundamentals to biodetection.
Q37095640Lanthanides: Applications in Cancer Diagnosis and Therapy
Q41856837Leach-proof magnetic thrombolytic nanoparticles and coatings of enhanced activity
Q90093902Levels of Soluble Urokinase Plasminogen Activator Receptor in Pediatric Lower Respiratory Tract Infections
Q34466969Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures
Q33278178Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region
Q30380709Mapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallography
Q47726693Mimicking Intermolecular Interactions of Tight Protein-Protein Complexes for Small-Molecule Antagonists.
Q35604600Mimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor.
Q48165741Multibiomarker analysis in patients with acute myocardial infarction
Q38870726Multifunctional Nano-Bioprobes Based on Rattle-Structured Upconverting Luminescent Nanoparticles.
Q27652688NMR Solution Structure of the Neurotrypsin Kringle Domain † ‡
Q64245273Nanoparticle Binding to Urokinase Receptor on Cancer Cell Surface Triggers Nanoparticle Disintegration and Cargo Release
Q90662820Novel Biomarkers in Patients with Chronic Kidney Disease: An Analysis of Patients Enrolled in the GCKD-Study
Q45927197Orientation-controlled conjugation of haloalkane dehalogenase fused homing peptides to multifunctional nanoparticles for the specific recognition of cancer cells.
Q61446738Origin and diversification of the plasminogen activation system among chordates
Q39679559Overexpression of the urokinase receptor mRNA splice variant uPAR-del4/5 affects tumor-associated processes of breast cancer cells in vitro and in vivo
Q34430691Pericellular proteolysis in cancer
Q93117519Predictive value of soluble urokinase-type plasminogen activator receptor for mortality in patients with suspected myocardial infarction
Q38164339Primary focal and segmental glomerulosclerosis and soluble factor urokinase-type plasminogen activator receptor
Q24299743Pro-urokinase-type plasminogen activator is a substrate for hepsin
Q33758094Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor
Q92256627Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
Q33795055Proteases Revisited: Roles and Therapeutic Implications in Fibrosis
Q35560686Proteases involved in cartilage matrix degradation in osteoarthritis.
Q37783622Radiometallated Peptides Targeting Guanylate Cyclase C and the Urokinase-Type Plasminogen Activator Receptor
Q37660895Regulation of cell signalling by uPAR.
Q33683537Retro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas.
Q36997616Role of urokinase receptor in tumor progression and development
Q33743804SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker
Q30496585Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
Q34370103Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding.
Q89846943Sex Differences in Circulating Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels and Adverse Outcomes in Coronary Artery Disease
Q36549551Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models
Q36276812Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction
Q101238345Small-Molecule Inhibition of the uPAR•uPA Interaction by Conformational Selection
Q34587758Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis
Q45306072Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients.
Q46281060Soluble Urokinase Plasminogen Activator Receptor: A New Biomarker in the Pediatric Intensive Care Unit
Q99608131Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI
Q36429637Soluble Urokinase Receptor and Chronic Kidney Disease.
Q33741426Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus.
Q40261498Soluble urokinase plasminogen activator receptor and hypertension among black South Africans after 5 years
Q92277771Structural Biology and Protein Engineering of Thrombolytics
Q47098588Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors
Q27650677Structural basis for EGFR ligand sequestration by Argos
Q36237711Structural basis of interaction between urokinase-type plasminogen activator and its receptor
Q27659603Structure-based Engineering of Species Selectivity in the Interaction between Urokinase and Its Receptor: IMPLICATION FOR PRECLINICAL CANCER THERAPY
Q38120755Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist
Q92757292Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity
Q39154565Sub-10 nm lanthanide-doped CaF2 nanoprobes for time-resolved luminescent biodetection.
Q33912826Synthesis and characterization of an (111)In-labeled peptide for the in vivo localization of human cancers expressing the urokinase-type plasminogen activator receptor (uPAR)
Q34555267Targeting NF-κB in infantile hemangioma-derived stem cells reduces VEGF-A expression.
Q35563311Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion
Q47140492Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells.
Q30393215Targeting therapeutics across the blood brain barrier (BBB), prerequisite towards thrombolytic therapy for cerebrovascular disorders-an overview and advancements
Q36442395The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (PAI-1) for the Low Density Lipoprotein Receptor-related Protein (LRP1) Is Composed of Four Basic Residues
Q47638043The Neurobiological Basis of Sleep: Insights from Drosophila
Q36805290The inhibitory effect of HKa in endothelial cell tube formation is mediated by disrupting the uPA-uPAR complex and inhibiting its signaling and internalization
Q36997621The many spaces of uPAR: delivery of theranostic agents and nanobins to multiple tumor compartments through a single target
Q37285095The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells.
Q37255861The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia.
Q37688084The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells.
Q90171163Therapeutics targeting the fibrinolytic system
Q89537067Tumor Targeting Chemo- and Photodynamic Therapy Packaged in Albumin for Enhanced Anti-Tumor Efficacy
Q40058871Type II transmembrane serine proteases as potential target for anti-influenza drug discovery
Q38685434Unwinding focal segmental glomerulosclerosis
Q34100895Urokinase receptor promotes ovarian cancer cell dissemination through its 84-95 sequence.
Q26865306Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target: potential clinical applications
Q46470855Urokinase-type plasminogen activator receptor induces conformational changes in the integrin alphaMbeta2 headpiece and reorientation of its transmembrane domains
Q36201781Urokinase-type plasminogen activator-like proteases in teleosts lack genuine receptor-binding epidermal growth factor-like domains.
Q27644652X-ray sequence and crystal structure of luffaculin 1, a novel type 1 ribosome-inactivating protein
Q28582042siRNA against plasminogen activator inhibitor-1 ameliorates bleomycin-induced lung fibrosis in rats
Q30444144uPAR-induced cell adhesion and migration: vitronectin provides the key

Q107514742uPA-uPAR complexdescribed by sourceP1343