Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion

scientific article

Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID1221777
P698PubMed publication ID11311124

P2093author name stringY Sun
X Lu
B Wattam
D Shang
E Hyde
M Scully
S Egglezou
T Hughes
V Kakkar
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Solution Structure of Kistrin, a Potent Platelet Aggregation Inhibitor and GP IIb-IIIa AntagonistQ27651187
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspinQ27729807
Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clottingQ27730809
The nuclear magnetic resonance solution structure of flavoridin, an antagonist of the platelet GP IIb-IIIa receptorQ27731981
A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectinQ28645680
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptorsQ28645681
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeQ29616413
Crystallization and preliminary diffraction data of a platelet-aggregation inhibitor from the venom of Agkistrodon piscivorus piscivorus (North American water moccasin).Q30579648
Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitorsQ33404652
Platelets have more than one binding site for von Willebrand factorQ33821754
Disintegrins: a family of integrin inhibitory proteins from viper venomsQ37987662
Platelet inhibitor agents in cardiovascular disease: an updateQ38697658
Modulation of RGD sequence motifs regulates disintegrin recognition of alphaIIb beta3 and alpha5 beta1 integrin complexes. Replacement of elegantin alanine-50 with proline, N-terminal to the RGD sequence, diminishes recognition of the alpha5 beta1 cQ41769202
Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RQ41975301
Synthetic RGD peptides derived from the adhesive domains of snake-venom proteins: evaluation as inhibitors of platelet aggregationQ42254956
Nuclear magnetic resonance studies of the snake toxin echistatin. 1H resonance assignments and secondary structureQ43770791
Structural domains in venom proteins: evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursorQ44904045
A novel approach to the design of potent bioactive peptides by incorporation of proline brackets: antiplatelet effects of Arg-Gly-Asp peptides.Q45080636
Identification of a novel proline-directed serine/threonine protein kinase in rat pheochromocytoma.Q46078302
Substitutions of proline 42 to alanine and methionine 46 to asparagine around the RGD domain of the neurotoxin dendroaspin alter its preferential antagonism to that resembling the disintegrin elegantin.Q54595452
1H-NMR Assignments and Secondary Structure of Dendroaspin, an RGD-Containing Glycoprotein IIb-IIIa (alphaIIb-beta3) Antagonist with a Neurotoxin FoldQ63363703
1H-NMR studies and secondary structure of the RGD-containing snake toxin, albolabrinQ63363704
The solution structure of echistatin: evidence for disulphide bond rearrangement in homologous snake toxinsQ67584036
Sequential proton NMR assignments of kistrin, a potent platelet aggregation inhibitor and glycoprotein IIb-IIIa antagonistQ67741615
The secondary structure of echistatin from 1H-NMR, circular-dichroism and Raman spectroscopyQ67802267
Three-dimensional structure of echistatin, the smallest active RGD proteinQ67919161
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinaseQ68248825
Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venomsQ68840759
Interaction of fibronectin with its receptor on plateletsQ68939916
The interaction of thrombospondin with platelet glycoprotein GPIIb-IIIaQ69394865
Receptor-specific antiplatelet therapyQ69405261
Important role of the proline residue in the signal sequence that directs the secretion of human lysozyme in Saccharomyces cerevisiaeQ69506108
Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to plateletsQ70181883
Cysteine pairing in the glycoprotein IIbIIIa antagonist kistrin using NMR, chemical analysis, and structure calculationsQ70526265
Dendroaspin: a potent integrin receptor inhibitor from the venoms of Dendroaspis viridis and D. jamesoniiQ70599880
Basicity differences among peptide bondsQ71433382
Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascinQ71604213
P433issuePt 3
P407language of work or nameEnglishQ1860
P921main subjectplatelet aggregationQ14913634
cell adhesionQ187640
P304page(s)633-8
P577publication date2001-05-01
P1433published inBiochemical JournalQ864221
P1476titleEvaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion
P478volume355

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cites work (P2860)
Q40616251Mechanism of binding and internalization of ICAM-1-derived cyclic peptides by LFA-1 on the surface of T cells: a potential method for targeted drug delivery
Q33221762The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae).

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