Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma

scientific article

Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1003581599
P356DOI10.1054/BJOC.2001.2175
P932PMC publication ID2364004
P698PubMed publication ID11747337
P5875ResearchGate publication ID11610323

P2093author name stringM Stewart
M G Dunlop
P G Johnston
D I Jodrell
D B Longley
A Leitch
A M Lessells
N A Wong
L Brett
P2860cites workThymidylate synthase is localized to the nuclear periphery in the yeast Saccharomyces cerevisiaeQ27937141
5-fluorouracil steady state pharmacokinetics and outcome in patients receiving protracted venous infusion for advanced colorectal cancerQ28359288
Intracellular location of thymidylate synthase and its state of phosphorylationQ28580813
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complexQ28584078
Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancerQ33930691
The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer.Q50875167
p53 protein overexpression and response to biomodulated 5-fluorouracil chemotherapy in patients with advanced colorectal cancer.Q51035952
Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapyQ57567897
Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cellsQ68463821
Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodiesQ69898972
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumorsQ72611029
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracilQ72729387
Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracilQ73393205
Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancerQ73605081
Clonal growth of colorectal-carcinoma cell lines transplanted to nude miceQ73899306
Glyceraldehyde-3-phosphate dehydrogenase gene expression in human breast cancerQ73967003
Immunohistochemical determination of thymidylate synthase in colorectal cancer--methodological studiesQ74201989
The utility of the proliferative index in pretreatment biopsy specimens of esophageal squamous cell carcinomaQ74594482
DNA mismatch repair and colorectal cancerQ77129031
Immunohistochemical investigation of thymidylate synthase in cervical cancerQ77432079
5-fluorouracil: a pharmacological paradigm in the use of cytotoxicsQ77529134
Prognosis and prediction of response in breast cancer: the current role of the main biological markersQ77683176
Identification of in vivo target RNA sequences bound by thymidylate synthaseQ34608316
Mismatch repair proficiency and in vitro response to 5-fluorouracilQ35129256
Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapyQ36116454
Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patientsQ36621223
Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapyQ38466842
Significance of angiogenesis in tumour progression and metastasisQ40423643
Thymidylate synthase and drug resistanceQ40423844
A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significanceQ40872945
Inhibition of mouse thymidylate synthase promoter activity by the wild-type p53 tumor suppressor proteinQ41097416
Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissueQ41652928
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.Q41731908
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancerQ43960974
Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trialQ45961645
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reactionQ46100135
p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.Q46365618
p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site.Q46465176
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 3.0 UnportedQ15643954
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectcolorectal carcinomaQ25493920
P304page(s)1937-43
P577publication date2001-12-14
P1433published inBritish Journal of CancerQ326309
P1476titleNuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma
P478volume85

Reverse relations

cites work (P2860)
Q90687449A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model
Q36772028Cancer of the colon and rectum: potential effects of sex-age interactions on incidence and outcome
Q39644517Contribution of Thymidylate Synthase to Gemcitabine Therapy for Advanced Pancreatic Cancer
Q46160850Correlation between thymidylate synthase protein expression and gene polymorphism with clinicopathological parameters in colorectal carcinoma
Q36474351Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2'-deoxyuridine
Q92391312Deoxyuracil in DNA and disease: Genomic signal or managed situation?
Q89336851Dietary Uridine Decreases Tumorigenesis in the ApcMin/+ Model of Intestinal Cancer
Q35773077Distinct gene expression profiles of proximal and distal colorectal cancer: implications for cytotoxic and targeted therapy.
Q57004900Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice
Q46356485Folate-mediated one-carbon metabolism
Q36205831Genetic factors influencing pyrimidine-antagonist chemotherapy.
Q39189050Novel MEK inhibitor trametinib and other retinoblastoma gene (RB)-reactivating agents enhance efficacy of 5-fluorouracil on human colon cancer cells
Q40409889Nuclear expression of thymidylate synthase in colorectal cancer cell lines and clinical samples
Q47794376Nuclear thymidylate synthase expression in sporadic colorectal cancer depends on the site of the tumor
Q33320579Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy
Q36646148Role of biological markers in the clinical outcome of colon cancer
Q36610474Schedule-dependent activity of 5-fluorouracil and irinotecan combination in the treatment of human colorectal cancer: in vitro evidence and a phase I dose-escalating clinical trial.
Q45073488Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
Q39017134Targeting nuclear thymidylate biosynthesis
Q28274343The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer
Q54394304Thymidylate synthase expression and p21(WAF1)/p53 phenotype of colon cancers identify patients who may benefit from 5-fluorouracil based therapy.
Q37983841Trafficking of intracellular folates

Search more.