| scholarly article | Q13442814 |
| P2093 | author name string | T Münzel | |
| A Warnholtz | |||
| B Mayer | |||
| H Mollnau | |||
| T Meinertz | |||
| T Heitzer | |||
| C Brockhoff | |||
| S Henne | |||
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endothelium | Q111140 |
| sapropterin | Q419808 | ||
| P304 | page(s) | E36-41 | |
| P577 | publication date | 2000-02-04 | |
| P1433 | published in | Circulation Research | Q2599020 |
| P1476 | title | Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase | |
| P478 | volume | 86 |
| Q37226233 | A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization |
| Q43199664 | A weapon of endothelial cells for fighting vascular disease |
| Q79366304 | Acute effect of cigarette smoke and nicotine on airway blood flow and airflow in healthy smokers |
| Q42412241 | Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure |
| Q42207780 | Acute tetrahydrobiopterin supplementation attenuates sympathetic vasoconstrictor responsiveness in resting and contracting skeletal muscle of healthy rats |
| Q34239830 | Angiotensin II and atherosclerosis |
| Q35564251 | Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspring |
| Q58026233 | Antioxidant responses following active and passive smoking of tobacco and electronic cigarettes |
| Q31935120 | Antioxidants and endothelial dysfunction in hyperlipidemia |
| Q26782715 | Association of smoking with restenosis and major adverse cardiac events after coronary stenting: A meta-analysis |
| Q37078834 | Atorvastatin restores endothelial function in normocholesterolemic smokers independent of changes in low-density lipoprotein |
| Q37408109 | C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling |
| Q35073570 | Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia |
| Q37588143 | Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation |
| Q28543569 | Cell-based screening identifies the active ingredients from Traditional Chinese Medicine formula Shixiao San as the inhibitors of atherosclerotic endothelial dysfunction |
| Q35044339 | Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability |
| Q38261420 | Central role of eNOS in the maintenance of endothelial homeostasis |
| Q34502041 | Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice |
| Q28572685 | Chronic exposure to arsenic in tap water reduces acetylcholine-induced relaxation in the aorta and increases oxidative stress in female rats |
| Q41966707 | Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice |
| Q30422894 | Cigarette smoke and inflammation: role in cerebral aneurysm formation and rupture |
| Q34412164 | Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation. |
| Q33242082 | Clinical methods for the evaluation of endothelial function-- a focus on resistance arteries |
| Q35686074 | Comparative study of serum MDA and vitamin C levels in non-smokers, chronic smokers and chronic smokers with acute myocardial infarction in men |
| Q44574641 | Coronary vasoregulation in patients with various risk factors in response to cold pressor testing: contrasting myocardial blood flow responses to short- and long-term vitamin C administration |
| Q43267895 | Dihydrofolate reductase and biopterin recycling in cardiovascular disease |
| Q53743021 | Does endothelial tetrahydrobiopterin control the endothelial NO synthase coupling state in arterial resistance arteries? |
| Q35645180 | Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model |
| Q33847029 | Early and late response-to-injury in patients undergoing transradial coronary angiography: arterial remodeling in smokers |
| Q44976959 | Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats |
| Q36940593 | Effects of Diabetes on Salivary Gland Protein Expression of Tetrahydrobiopterin and Nitric Oxide Synthesis and Function |
| Q38741534 | Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice. |
| Q46201185 | Effects of tetrahydrobiopterin on venous bubble grade and acute diving-induced changes in cardiovascular function |
| Q35913809 | Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. |
| Q35947546 | Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing |
| Q35188942 | Endothelial dysfunction: clinical strategies for treating oxidant stress |
| Q35013018 | Endothelial function. From vascular biology to clinical applications |
| Q36992714 | Endothelial nitric oxide (NO) and its pathophysiologic regulation |
| Q35046483 | Endothelial nitric oxide synthase polymorphisms and hypertension |
| Q45096390 | Exogenous NO suppresses flow-induced endothelium-derived NO production because of depletion of tetrahydrobiopterin |
| Q26801173 | Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease |
| Q33701506 | Folic acid treatment normalizes NOS-dependence of vascular tone in the metabolic syndrome |
| Q28256495 | Free radical production by dysfunctional eNOS |
| Q37235626 | GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function |
| Q35206849 | Gender bias in gastroparesis: is nitric oxide the answer? |
| Q35110921 | Genetic influence on cigarette-induced cardiovascular disease |
| Q37071433 | Greater γ-tocopherol status during acute smoking abstinence with nicotine replacement therapy improved vascular endothelial function by decreasing 8-iso-15(S)-prostaglandin F2α. |
| Q37107580 | Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells |
| Q37327619 | Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo |
| Q41176327 | Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms |
| Q93186392 | Immunological Regulation of Vascular Inflammation During Cancer Metastasis |
| Q39418950 | Impact of Oxidative Stress on the Heart and Vasculature: Part 2 of a 3-Part Series |
| Q34547136 | Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids |
| Q35170674 | Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation |
| Q57141714 | Implications of endothelial shear stress on systemic sclerosis vasculopathy and treatment |
| Q46905216 | Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice |
| Q28566423 | Increased vascular contractility in isolated vessels from cigarette smoking rats is mediated by basal endothelin release |
| Q35021915 | Increasing muscle mass improves vascular function in obese (db/db) mice |
| Q34283413 | Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II |
| Q35090077 | Insulin resistance and compensatory hyperinsulinemia: the key player between cigarette smoking and cardiovascular disease? |
| Q43988591 | Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function |
| Q31448793 | L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin |
| Q36203008 | Lower hypoxic ventilatory response in smokers compared to non-smokers during abstinence from cigarettes |
| Q36176310 | Mechanisms underlying endothelial dysfunction in diabetes mellitus: therapeutic implications |
| Q33589250 | Methylglyoxal modulates endothelial nitric oxide synthase-associated functions in EA.hy926 endothelial cells |
| Q35976043 | Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome |
| Q31145647 | NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy |
| Q60919681 | New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease |
| Q37097130 | New insights into the sympathetic, endothelial and coronary effects of nicotine |
| Q37715827 | Nitric oxide and oxidative stress in vascular disease |
| Q35874972 | Nitric oxide insufficiency and atherothrombosis |
| Q33680902 | Nitric oxide pathways and evidence-based perturbations in acute pancreatitis |
| Q35090367 | Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction |
| Q37887771 | Nitric oxide: a guardian for vascular grafts? |
| Q35848552 | Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin |
| Q36684472 | Novel therapies targeting vascular endothelium |
| Q33743649 | Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load |
| Q30080036 | Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension |
| Q37373701 | Oxidative stress and accelerated vascular aging: implications for cigarette smoking |
| Q37867946 | Oxidative stress and endothelial dysfunction in hypertension |
| Q34038044 | Oxidative stress and metabolic pathologies: from an adipocentric point of view. |
| Q35200733 | Oxidative stress and smoking-induced vascular injury |
| Q37738027 | Oxidative stress and vascular function: implications for pharmacologic treatments |
| Q37003803 | Oxidative stress in diabetic nephropathy |
| Q36795759 | Oxidative stress in the cardiorenal metabolic syndrome |
| Q37079745 | Plant-Derived Small Molecule Inhibitors of Neuronal NO-Synthase: Potential Effects on Protein Degradation |
| Q34189108 | Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000. |
| Q35029413 | Post-translational mechanisms of endothelial nitric oxide synthase regulation by bradykinin |
| Q21129237 | Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium |
| Q46782410 | Prevention of coronary heart disease: smoking |
| Q36403729 | Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin |
| Q46660120 | Protective effects of silybin on human umbilical vein endothelial cell injury induced by H2O2 in vitro |
| Q39916287 | Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression |
| Q37294875 | Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. |
| Q27024762 | Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications |
| Q35888592 | Reactive oxygen species-mediated signal transduction in the endothelium |
| Q26822833 | Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling |
| Q36970633 | Redox control of renal function and hypertension. |
| Q37446110 | Redox signaling in cardiovascular health and disease. |
| Q46664797 | Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults? |
| Q34967386 | Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs. |
| Q35792741 | Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin |
| Q31062227 | Response of choroidal blood flow to carbogen breathing in smokers and non-smokers |
| Q94464751 | Role of the eNOS Uncoupling and the Nitric Oxide Metabolic Pathway in the Pathogenesis of Autoimmune Rheumatic Diseases |
| Q37306295 | Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function |
| Q37264364 | Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. |
| Q46690166 | Short-term exposure to cigarette smoke induces endothelial dysfunction in small intrapulmonary arteries: analysis using guinea pig precision cut lung slices |
| Q33760484 | Silent Partner in Blood Vessel Homeostasis? Pervasive Role of Nitric Oxide in Vascular Disease |
| Q37198120 | Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunction |
| Q38112118 | Site-specific antioxidative therapy for prevention of atherosclerosis and cardiovascular disease |
| Q43061592 | Smoking and atherosclerotic cardiovascular disease: part II: role of cigarette smoking in cardiovascular disease development |
| Q36032937 | Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis |
| Q58075704 | Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation |
| Q35047327 | Synergistic interaction between enalapril, L-arginine and tetrahydrobiopterin in smooth muscle cell apoptosis and aortic remodeling induction in SHR. |
| Q37873087 | Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease |
| Q34252918 | Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease |
| Q37968218 | Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities |
| Q37860512 | Targeting endothelial and myocardial dysfunction with tetrahydrobiopterin |
| Q38836199 | Targeting vascular (endothelial) dysfunction. |
| Q37119356 | Tetrahydrobiopterin |
| Q37211804 | Tetrahydrobiopterin ameliorates the exaggerated exercise pressor response in patients with chronic kidney disease: a randomized controlled trial |
| Q42165624 | Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction |
| Q46685929 | Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults |
| Q46555003 | Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction |
| Q44888140 | Tetrahydrobiopterin improves endothelial dysfunction and vascular oxidative stress in microvessels of intrauterine undernourished rats. |
| Q43703666 | Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease |
| Q35850060 | Tetrahydrobiopterin improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women |
| Q34753845 | Tetrahydrobiopterin improves endothelial function in cardiovascular disease: a systematic review |
| Q33687812 | Tetrahydrobiopterin in cardiovascular health and disease |
| Q34495148 | Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms |
| Q35035498 | Tetrahydrobiopterin lowers muscle sympathetic nerve activity and improves augmentation index in patients with chronic kidney disease |
| Q102075368 | Tetrahydrobiopterin prevents chronic ischemia-related lower urinary tract dysfunction through the maintenance of nitric oxide bioavailability |
| Q44429099 | Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects |
| Q30813656 | Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia |
| Q36352929 | Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study |
| Q33779913 | Tetrahydrobiopterin, superoxide, and vascular dysfunction |
| Q46716730 | Tetrahydrobiopterin: a novel antihypertensive therapy |
| Q50238440 | Tetrahydrobiopterin: a vascular redox target to improve endothelial function. |
| Q41660449 | The Future Challenge of Reactive Oxygen Species (ROS) in Hypertension: From Bench to Bed Side |
| Q44417248 | The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen |
| Q37804394 | The combined effect of hypertension and smoking on arterial stiffness |
| Q62078862 | The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis |
| Q38835675 | The eNOS signalosome and its link to endothelial dysfunction. |
| Q34214486 | The endothelium: dysfunction and beyond |
| Q86805469 | The impact of tetrahydrobiopterin administration on endothelial function before and after smoking cessation in chronic smokers |
| Q28582766 | The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein |
| Q36961504 | The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes |
| Q35055194 | The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function |
| Q28609860 | The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study |
| Q38103265 | The regulation of vascular tetrahydrobiopterin bioavailability |
| Q54854556 | The role of tetrahydrobiopterin in inflammation and cardiovascular disease. |
| Q35888589 | The two faces of endothelial nitric oxide synthase in the pathophysiology of atherosclerosis |
| Q35216447 | Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling |
| Q37676401 | Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo |
| Q24650649 | Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction |
| Q44782961 | Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction |
| Q35978134 | Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches |
| Q26779400 | Vascular nitric oxide: Beyond eNOS |
| Q37087728 | Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects |
| Q80393843 | [Oxidative stress and sleep apnea-hypopnea syndrome] |
| Q35889758 | eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity |
| Q36153314 | l-arginine and l-NMMA for assessing cerebral endothelial dysfunction in ischaemic cerebrovascular disease: A systematic review. |
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