Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity

scientific article

Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1345/APH.18319
P3181OpenCitations bibliographic resource ID2445365
P698PubMed publication ID10492502
P5875ResearchGate publication ID12806738

P2093author name stringJ A Rey
C A Luque
P2860cites workA comparison of sibutramine and dexfenfluramine in the treatment of obesityQ74830575
Valvular heart disease associated with fenfluramine-phentermineQ28247282
Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat.Q35026535
Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesityQ35329220
Appetite suppressants. A reviewQ35329355
Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidenceQ38473880
Medical hazards of obesityQ40841355
Dexfenfluramine. An updated review of its therapeutic use in the management of obesityQ41445495
A comparison of the effects on central 5-HT function of sibutramine hydrochloride and other weight-modifying agentsQ41894548
The effects of BTS 54,505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivoQ41897251
Clinical pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant, in healthy volunteersQ41938591
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the ratQ42057930
Characterization of P1-purinoceptors on rat isolated duodenum longitudinal muscle and muscularis mucosaeQ42705852
Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressantsQ42717226
A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramineQ44773878
The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochlorideQ44971989
Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramineQ47265863
Sibutramine produces dose-related weight lossQ47268542
Sibutramine: a new weight loss agent without evidence of the abuse potential associated with amphetaminesQ47287928
Effects of sibutramine on resting metabolic rate and weight loss in overweight womenQ47291749
Sibutramine in weight control: a dose-ranging, efficacy studyQ47425497
The pharmacology of sibutramine hydrochloride (BTS 54 524), a new antidepressant which induces rapid noradrenergic down-regulationQ48163276
[3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatmentsQ48235129
A comparison of various antidepressant drugs demonstrates rapid desensitisation of alpha 2-adrenoceptors exclusively by sibutramine hydrochlorideQ48594070
Sibutramine pharmacokinetics in young and elderly healthy subjects.Q53936931
Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: executive summary. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in AdultsQ63258542
Overweight and obesity in the United States: prevalence and trends, 1960-1994Q64133342
Effects of antidepressant drugs and electroconvulsive shock on pre- and postsynaptic α2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochlorideQ67916046
Effect on radiolabelled-monoamine uptake in vitro of plasma taken from healthy volunteers administered the antidepressant sibutramine HClQ68732527
Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortexQ69355041
[3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatmentsQ71201871
A double-blind randomized placebo-controlled trial of sibutramineQ71329417
D1 receptor binding in rat striatum: modification by various D1 and D2 antagonists, but not by sibutramine hydrochloride, antidepressants or treatments which enhance central dopaminergic functionQ71479809
Long-term pharmacotherapy in the management of obesity. National Task Force on the Prevention and Treatment of ObesityQ71899836
Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermineQ73626953
Efficacy and tolerability of sibutramine in obese patients: a dose-ranging studyQ74240207
Sibutramine reduces food intake in non-dieting women with obesityQ74397262
The cost of obesity: the US perspectiveQ74823666
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectserotoninQ167934
obesityQ12174
(RS)-sibutramineQ424151
norepinephrineQ186242
P304page(s)968-78
P577publication date1999-09-01
P1433published inAnnals of PharmacotherapyQ4767858
P1476titleSibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity
P478volume33

Reverse relations

cites work (P2860)
Q419805355-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials
Q37995983A review of unmet needs in obesity management
Q36007869Advances in diabetes for the millennium: nutritional therapy of type 2 diabetes
Q42825533Anti-Obesity Effects of the Mixture of Eriobotrya japonica and Nelumbo nucifera in Adipocytes and High-Fat Diet-Induced Obese Mice.
Q42321603Anti-obesity effects of Boussingaulti gracilis Miers var. pseudobaselloides Bailey via activation of AMP-activated protein kinase in 3T3-L1 cells
Q33841823Anti-obesity effects of Lysimachia foenum-graecum characterized by decreased adipogenesis and regulated lipid metabolism.
Q36995285Antiadipogenic Effects of Aster glehni Extract: In Vivo and In Vitro Effects.
Q29308187Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects
Q27902304ChemDIS: a chemical–disease inference system based on chemical–protein interactions
Q34983224Chinese slimming capsules containing sibutramine sold over the Internet: a case series
Q53069361Combination of Garcinia cambogia Extract and Pear Pomace Extract Additively Suppresses Adipogenesis and Enhances Lipolysis in 3T3-L1 Cells.
Q45097301Comparison of efficacy of sibutramine or orlistat versus their combination in obese women.
Q43236004Comparison of the effects of sibutramine versus sibutramine plus metformin in obese women
Q35992004Contemporary approaches into obesity: drugs and genes
Q46316802Effects of sibutramine and rimonabant in rats trained to discriminate between 22- and 2-h food deprivation
Q43944301Effects of sibutramine in non-dieting obese women
Q46422665Effects of sibutramine on abdominal fat mass, insulin resistance and blood pressure in obese hypertensive patients.
Q43882702Efficacy and safety of sibutramine for weight loss in obese patients with hypertension well controlled by beta-adrenergic blocking agents: a placebo-controlled, double-blind, randomised trial
Q46336288Electrophysiological safety of sibutramine HCl.
Q33805817Extracts from "Clinical Evidence". Obesity.
Q35060413HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice
Q44525141Health risks, past usage, and intention to use weight loss products in normal weight women with high and low body dysphoria
Q37733914Identification and determination of synthetic pharmaceuticals as adulterants in eight common herbal weight loss supplements.
Q38827616Inhibitory effects of Aster spathulifolius extract on adipogenesis and lipid accumulation in 3T3-L1 preadipocytes
Q44482870Interaction between sibutramine and cyclosporine
Q37173554Interaction of Veratrum nigrum with Panax ginseng against Obesity: A Sang-ban Relationship
Q38289411Korean Chungtaejeon tea extract attenuates body weight gain in C57BL/6J-Lep ob/ob mice and regulates adipogenesis and lipolysis in 3T3-L1 adipocytes.
Q24247723Long-term pharmacotherapy for obesity and overweight
Q35029802Management of obesity as a chronic disease: nonpharmacologic, pharmacologic, and surgical options
Q34788366Modafinil decreases food intake in humans subjected to simulated shift work
Q28066691Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases
Q48706402Narcolepsy and obesity: remission of severe cataplexy with sibutramine
Q38998472New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms.
Q37061997Obesity: a review of pathogenesis and management strategies
Q34014388Obesity: an epidemic in need of therapeutics
Q24792455Obesity: an overview on its current perspectives and treatment options
Q34182135Orlistat in the treatment of obesity
Q34191297Orlistat--a novel weight loss therapy
Q33996725Pharmacological treatment of obesity
Q22251113Pharmacology of stimulants prohibited by the World Anti-Doping Agency (WADA)
Q37585306Polycystic ovary syndrome, obesity and reproductive implications
Q53687735Potential Hypoglycaemic and Antiobesity Effects of Senna italica Leaf Acetone Extract.
Q36936358Present and future therapeutic strategies in non-alcoholic fatty liver disease
Q42850075Psychosis associated with usage of herbal slimming products adulterated with sibutramine: a case series
Q45908028Reversal of sibutramine-induced anorexia with a selective 5-HT(2C) receptor antagonist.
Q24244078Rimonabant for overweight or obesity
Q45935486Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma.
Q43011934Sibutramine effects on the reproductive performance of pregnant overweight and non-overweight rats
Q43882700Sibutramine is safe and effective for weight loss in obese patients whose hypertension is well controlled with angiotensin-converting enzyme inhibitors
Q34585304Sibutramine-associated adverse effects: a practical guide for its safe use.
Q58068053The Effect of Sibutramine, a Serotonin-Norepinephrine Reuptake Inhibitor, on Platelets and Fibrin Networks of Male Sprague-Dawley Rats: A Descriptive Study
Q34128195The discovery and status of sibutramine as an anti-obesity drug
Q46419827The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes
Q35102481Understanding the new and evolving profile of adverse drug effects in schizophrenia
Q35563443Use of sibutramine to treat obesity
Q36814522Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro
Q75344159[Overweight and obesity in adults: recommendations and treatment algorithms]

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