Genetic variants and risk of lung cancer in never smokers: a genome-wide association study

scientific article

Genetic variants and risk of lung cancer in never smokers: a genome-wide association study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1470-2045(10)70042-5
P3181OpenCitations bibliographic resource ID4778378
P932PMC publication ID2945218
P698PubMed publication ID20304703

P50authorDavid C. ChristianiQ30069760
Mariza de AndradeQ42067404
Zhifu SunQ47119878
Chau-Chyun SheuQ57018386
Zuo-Feng ZhangQ57419786
Julie M. CunninghamQ67440680
P2093author name stringFeng Chen
Li Su
Ping Yang
Yan Li
Jin Jen
Hui Tang
V Shane Pankratz
George Vasmatzis
Liang Wang
Mark S Allen
Jie Lin
Margaret R Spitz
Xifeng Wu
Yuanqing Ye
Yafei Li
Claude Deschamps
Curtis C Harris
Shen-Chih Chang
Ruoxiang Jiang
Marie C Aubry
Randolph S Marks
Jeremiah A Aakre
Renyi Wang
P2860cites workLocalisation of a novel region of recurrent amplification in follicular lymphoma to an approximately 6.8 Mb region of 13q32-33Q74576339
Clinical features of 5,628 primary lung cancer patients: experience at Mayo Clinic from 1997 to 2003Q80345591
Health consequences of sustained smoking cessationQ83379091
Phenotype and 244k array-CGH characterization of chromosome 13q deletions: an update of the phenotypic map of 13q21.1-qterQ83641039
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serumQ21145030
Population structure and eigenanalysisQ21145248
GlypicansQ21183908
Lung cancer risk and workplace exposure to environmental tobacco smokeQ23916899
Common 5p15.33 and 6p21.33 variants influence lung cancer riskQ24646182
Somatic mutations affect key pathways in lung adenocarcinomaQ24648102
Lung cancer susceptibility locus at 5p15.33Q24649980
Revealing the architecture of gene regulation: the promise of eQTL studiesQ24657564
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Global cancer statistics, 2002Q27860562
Principal components analysis corrects for stratification in genome-wide association studiesQ27860975
Glypicans in growth control and cancerQ28185369
Developmental roles of the glypicansQ28211145
Lung cancer in never smokers: a reviewQ28287500
Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene familyQ28305988
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosisQ28943261
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1Q28943480
Common regulatory variation impacts gene expression in a cell type-dependent mannerQ29614882
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25Q29614944
Lung cancer in never smokers--a different diseaseQ29615414
Genetic analysis of genome-wide variation in human gene expressionQ29617852
Wnt signalling and its impact on development and cancerQ29619273
Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling schemeQ31114297
Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survivalQ33320978
A rigorous and comprehensive validation: common genetic variations and lung cancerQ33586584
Heparan sulfate proteoglycans and cancer.Q34441253
Modifying risk of developing lung cancer by changing habits of cigarette smokingQ34551015
Second hand smoke, age of exposure and lung cancer riskQ34587020
Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.Q34736044
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate geneQ34974643
Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokersQ35015670
Lung cancer in never-smokersQ36026075
Alpha1-antitrypsin deficiency carriers, tobacco smoke, chronic obstructive pulmonary disease, and lung cancer riskQ36926072
Genetic similarities between organogenesis and tumorigenesis of the lung.Q37078785
Lung cancer epigenetics and geneticsQ37143369
Identifying and recruiting healthy control subjects from a managed care organization: a methodology for molecular epidemiological case-control studies of cancerQ39451329
Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancersQ40285059
Faster cyclic loess: normalizing RNA arrays via linear modelsQ50774624
Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma.Q55475292
Prospective study of smoking, antioxidant intake, and lung cancer in middle-aged women (USA)Q57751041
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breastQ57791027
Gene Expression in Lung Adenocarcinomas of Smokers and NonsmokersQ60609569
Lung Cancer Risk Reduction After Smoking Cessation: Observations From a Prospective Cohort of WomenQ61670391
P4510describes a project that usesgenome-wide association studyQ1098876
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
genome-wide association studyQ1098876
P304page(s)321-330
P577publication date2010-03-19
P1433published inLancet Oncology CommissionQ13747613
P1476titleGenetic variants and risk of lung cancer in never smokers: a genome-wide association study
P478volume11

Reverse relations

cites work (P2860)
Q92345986A Hidden Epidemic of "Intermediate Risk" Oropharynx Cancer
Q38671004A decade of GWAS results in lung cancer.
Q83595575A lung cancer gene GPC5 could also be crucial in breast cancer
Q38211430A symbiotic liaison between the genetic and epigenetic code
Q41082130A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.
Q34031242Acetylcholine receptor pathway in lung cancer: New twists to an old story
Q55431061Advances in early diagnosis of lung cancer
Q43159134Analysis of susceptible genes and chromosome loci for lung cancers by automated gene prediction tools and genome scanning meta-analysis
Q37941513Antithetic roles of proteoglycans in cancer.
Q98386137Artificial intelligence powered statistical genetics in biobanks
Q22122086Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population
Q41980732Association between Interleukin-1β Gene -511C>T/+3954C>T Polymorphisms and Aggressive Periodontitis Susceptibility: Evidence from a Meta-Analysis
Q37879972Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis
Q34449854Attributing effects to interactions
Q38844239Biomarker development in the precision medicine era: lung cancer as a case study.
Q30248745Biomarkers of genome instability and cancer epigenetics.
Q42151956Chromatin patterns associated with lung adenocarcinoma progression
Q35088670Classification of non-small cell lung cancer based on copy number alterations
Q34013428Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA
Q34534035Comparative Analysis of Methods for Identifying Recurrent Copy Number Alterations in Cancer
Q35290271Correlation between familial cancer history and epidermal growth factor receptor mutations in Taiwanese never smokers with non-small cell lung cancer: a case-control study
Q92510114Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans
Q35753633Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma
Q64267086Disentangling tobacco-related lung cancer-genome-wide interaction study of smoking behavior and non-small cell lung cancer risk
Q28740835Dissecting cis regulation of gene expression in human metabolic tissues
Q46653404EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women
Q34776412Effect of single nucleotide polymorphism Rs189037 in ATM gene on risk of lung cancer in Chinese: a case-control study
Q36487146Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk
Q64939617Extracting predictors for lung adenocarcinoma based on Granger causality test and stepwise character selection.
Q36592419Family history of lung cancer in never smokers with non-small-cell lung cancer and its association with tumors harboring EGFR mutations
Q33352142Filtering the genes and sorting the glomerular filter: a new piece in the puzzle?
Q64929118Fine Mapping in Chromosome 3q28 Identified Two Variants Associated with Lung Cancer Risk in Asian Population.
Q36326842Functional characterization of RAD52 as a lung cancer susceptibility gene in the 12p13.33 locus
Q38043172Future Trends in Lung Cancer Diagnosis
Q41786499GPC5 Gene and Its Related Pathways in Lung Cancer
Q84675270GPC5 and lung cancer in multiple sclerosis
Q46365378GPC5 rs2352028 polymorphism and risk of lung cancer in Han Chinese
Q43012778GPC5 rs2352028 variant and risk of lung cancer in never smokers
Q61180898GPC5 rs2352028 variant and risk of lung cancer in never smokers – Authors' reply
Q40764161GPC5, a novel epigenetically silenced tumor suppressor, inhibits tumor growth by suppressing Wnt/β-catenin signaling in lung adenocarcinoma
Q37270019GWAS meets TCGA to illuminate mechanisms of cancer predisposition.
Q36153364Gender-based impact of epidermal growth factor receptor mutation in patients with nonsmall cell lung cancer and previous tuberculosis
Q26764865Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure
Q26862431Genetic Predisposition to Chronic Obstructive Pulmonary Disease and/or Lung Cancer: Important Considerations When Evaluating Risk
Q36148775Genetic Variants Associated with the Risk of Chronic Obstructive Pulmonary Disease with and without Lung Cancer
Q35963119Genetic Variants on 15q25.1, Smoking, and Lung Cancer: An Assessment of Mediation and Interaction
Q36925216Genetic evidence linking lung cancer and COPD: a new perspective
Q24606717Genetic susceptibility to lung cancer and co-morbidities
Q26852320Genetic susceptibility to lung cancer--light at the end of the tunnel?
Q37800567Genetics of lung-cancer susceptibility
Q37037246Genome-Wide Association Study of Genetic Predictors of Overall Survival for Non–Small Cell Lung Cancer in Never Smokers
Q36917140Genome-Wide Association Study of Lung Cancer in Korean Non-Smoking Women
Q34558036Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese
Q37045796Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy
Q90714959Genome-wide association study using diversity outcross mice identified candidate genes of pancreatic cancer
Q64975021Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco-induced lung cancer.
Q39107657Glypican-5 is a novel metastasis suppressor gene in non-small cell lung cancer
Q40217330Glypican-5 is a tumor suppressor in non-small cell lung cancer cells
Q37694835Glypican-5 suppresses Epithelial-Mesenchymal Transition of the lung adenocarcinoma by competitively binding to Wnt3a
Q58705289Heparan Sulfate and Heparan Sulfate Proteoglycans in Cancer Initiation and Progression
Q28657828Heparan sulfate signaling in cancer
Q38651957High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification
Q36695173Homogeneous case subgroups increase power in genetic association studies
Q36255653Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia
Q33567579Increased BCAR1 predicts poor outcomes of non-small cell lung cancer in multiple-center patients
Q24595630Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers
Q37798946Induction of Epigenetic Alterations by Dietary and Other Environmental Factors
Q34076429Inflammation-related genetic variations and survival in patients with advanced non-small cell lung cancer receiving first-line chemotherapy
Q34539540Ionizing radiation-induced γ-H2AX activity in whole blood culture and the risk of lung cancer
Q36258075Lung Cancer Risk Prediction Using Common SNPs Located in GWAS-Identified Susceptibility Regions
Q90157503Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region
Q38669269Lung Cancer in Never Smokers
Q24630167Lung Cancer: Epidemiology, Etiology, and Prevention
Q28386853Lung cancer in never smokers
Q55342417Lung cancer in never smokers from the Princess Margaret Cancer Centre.
Q37998646Lung cancer in never smokers – A review
Q37944937Lung cancer in never smokers.
Q34362241Lung cancer in never smokers: Disease characteristics and risk factors
Q44539648Lung cancer in never smokers: a new hot area of research
Q39741320Lung cancers unrelated to smoking: characterized by single oncogene addiction?
Q34091855Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
Q34993703Molecular analysis of human papillomavirus in never-smokers with non-small cell lung cancer
Q89585803Multiple genome pattern analysis and signature gene identification for the Caucasian lung adenocarcinoma patients with different tobacco exposure patterns
Q37536837Multiple-level validation identifies PARK2 in the development of lung cancer and chronic obstructive pulmonary disease
Q64039545Pathogenic Variants in GPC4 Cause Keipert Syndrome
Q37088999Performance of an item response theory-based computer adaptive test in identifying functional decline
Q35590957Polymorphisms in C-reactive protein and Glypican-5 are associated with lung cancer risk and Gartrokine-1 influences Cisplatin-based chemotherapy response in a Chinese Han population.
Q47254894Polymorphisms in genes related to epithelial-mesenchymal transition and risk of non-small cell lung cancer
Q51589742Prediction of cancer prognosis with the genetic basis of transcriptional variations
Q36808416Predictors of Survival in Never-Smokers with Non–Small Cell Lung Cancer: A Large-Scale, Two-Phase Genetic Study
Q34570834Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies
Q37461909Prioritization of SNPs for Genome-Wide Association Studies Using an Interaction Model of Genetic Variation, Gene Expression, and Trait Variation
Q41078073Prognostic significance of GPC5 expression in patients with prostate cancer
Q37775627Prospects for molecular staging of non-small-cell lung cancer from genomic alterations
Q35599740Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors.
Q36816444Proteoglycans and their roles in brain cancer
Q39416722Rationale and Design of the Japan Molecular Epidemiology for Lung Cancer Study
Q44822764Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.
Q93068318SNPs in LncRNA genes are associated with non-small cell lung cancer in a Chinese population
Q47561797Screening for Lung Cancer: Who Should Be Screened?
Q33703646Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China.
Q37990779Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers.
Q34586191Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.
Q34210728The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations
Q35208501The BATTLE to Personalize Lung Cancer Prevention through Reverse Migration
Q36580787The Minnesota Center for Twin and Family Research genome-wide association study
Q34988362The impact of polymorphic variations in the 5p15, 6p12, 6p21 and 15q25 Loci on the risk and prognosis of portuguese patients with non-small cell lung cancer
Q42075639The overexpression of glypican-5 promotes cancer cell migration and is associated with shorter overall survival in non-small cell lung cancer
Q51811743Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes
Q37574431Variants in Inflammation Genes Are Implicated in Risk of Lung Cancer in Never Smokers Exposed to Second-hand Smoke
Q41613396WNT signaling - lung cancer is no exception.
Q37307499Women and lung cancer: what is new?

Search more.