Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days

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Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days is …
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scholarly articleQ13442814

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P356DOI10.1093/CARCIN/BGS247
P932PMC publication ID3499045
P698PubMed publication ID22828138
P5875ResearchGate publication ID230564490

P50authorOfelia OliveroQ104414395
Miriam C. PoirierQ107022221
Frederick A. BelandQ42700100
P2093author name stringIgor P Pogribny
Mona I Churchwell
Kaarthik John
Gail McMullen
M Margaret Pratt
P2860cites workHigh-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of benzo[a]pyrene-DNA adductsQ23912890
Carcinogen macromolecular adducts and their measurementQ23918490
CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllinQ24169869
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathwayQ24336089
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesisQ24656086
Cancer statistics, 2010Q27860525
Tumor spectrum analysis in p53-mutant miceQ29617436
Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA miceQ30797445
Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumorsQ30874637
Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa miceQ30908437
DNA repair and cancer: lessons from mutant mouse modelsQ31047958
DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyreneQ31400398
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour developmentQ32134347
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient miceQ33233722
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypesQ33322268
Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyreneQ33946239
Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancerQ33952070
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotypeQ34050632
Cancer and phase II drug-metabolizing enzymes.Q35061118
Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesisQ35576462
DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment.Q35662945
Overview of mechanisms of cancer chemopreventive agentsQ36233609
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor studyQ36363990
Nucleotide excision repair and cancerQ36541663
Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbonsQ36583341
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A geneQ36694651
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPAQ36694656
Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient miceQ36865063
The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancerQ37759799
Chlorophylls as anticarcinogens (review).Q37870741
Fifty years of benzo(a)pyreneQ40135204
Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymesQ40293597
Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometryQ40300421
Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbonsQ40372734
Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoringQ44266875
Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene in C57BL/6J mice.Q53289470
The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome.Q53342009
A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay.Q53437098
Chemopreventive activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.Q53455091
Derivative fluorescence spectral analysis of polycyclic aromatic hydrocarbon-DNA adducts in human placenta.Q53516618
Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.Q53535372
Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay.Q53578319
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the ratQ79750577
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecthaploinsufficiencyQ852654
P304page(s)2236-41
P577publication date2012-11-01
P1433published inCarcinogenesisQ326022
P1476titleBenzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days
P478volume33

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cites work (P2860)
Q38199542An evidence-based systematic review of chlorophyll by the Natural Standard Research Collaboration
Q34627161Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures
Q35215308Role of nucleotide excision repair and p53 in zidovudine (AZT)-induced centrosomal deregulation

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