Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms

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Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...624663C
P356DOI10.1371/JOURNAL.PONE.0024663
P3181OpenCitations bibliographic resource ID2167609
P932PMC publication ID3184941
P698PubMed publication ID21984893
P5875ResearchGate publication ID51704401

P50authorCarlo VancheriQ58348504
Filippo CaraciQ83164166
Nunzio CrimiQ42521194
P2093author name stringEnrico Conte
Evelina Fagone
Elisa Gili
Maria Iemmolo
Mary Fruciano
P2860cites workResveratrol inhibits transforming growth factor-β-induced proliferation and differentiation of ex vivo human lung fibroblasts into myofibroblasts through ERK/Akt inhibition and PTEN restoration.Q54617334
The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblastsQ68814555
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gammaQ79764493
Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2Q81480914
Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biologyQ83069601
Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-betaQ93534412
Phosphatidylinositol-3-Kinase/Akt regulates bleomycin-induced fibroblast proliferation and collagen productionQ23924071
Cardiac regulation by phosphoinositide 3-kinases and PTENQ24317248
TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathwaysQ24644667
The phosphoinositide 3-kinase pathwayQ27860738
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophilsQ28249042
Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosisQ33882371
Activity of any class IA PI3K isoform can sustain cell proliferation and survival.Q33952917
Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.Q34103575
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease.Q34571618
The PTEN-PI3K pathway: of feedbacks and cross-talksQ34828662
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.Q36751486
The pathogenesis of idiopathic pulmonary fibrosis.Q37800756
A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in ratsQ39868488
Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.Q40158710
Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysisQ40537092
Heterogeneous proliferative characteristics of human adult lung fibroblast lines and clonally derived fibroblasts from control and fibrotic tissueQ41434332
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e24663
P577publication date2011-10-03
P1433published inPLOS OneQ564954
P1476titleInhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms
P478volume6

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