Reactive astrocytes and therapeutic potential in focal ischemic stroke

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Reactive astrocytes and therapeutic potential in focal ischemic stroke is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.NBD.2015.05.003
P932PMC publication ID4644522
P698PubMed publication ID25982835

P2093author name stringGourav Roy Choudhury
Shinghua Ding
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Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicityQ23914345
Induction of gp130-related Cytokines and Activation of JAK2/STAT3 Pathway in Astrocytes Precedes Up-regulation of Glial Fibrillary Acidic Protein in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Model of NeurodegenerationQ23916363
Molecular dissection of reactive astrogliosis and glial scar formationQ24646628
Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivoQ27301015
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Dynamic reactive astrocytes after focal ischemiaQ28083738
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Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiationQ28508728
ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activationQ28537957
Loss of glial fibrillary acidic protein results in decreased glutamate transport and inhibition of PKA-induced EAAT2 cell surface traffickingQ28590935
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and functionQ29547320
A translational profiling approach for the molecular characterization of CNS cell typesQ29615252
Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domainsQ29619208
MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65.Q30439375
TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke.Q30479052
Chondroitin-4-sulfation negatively regulates axonal guidance and growthQ30483928
Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivoQ30484581
General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortexQ30528536
Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after strokeQ30534310
High susceptibility to cerebral ischemia in GFAP-null miceQ30887270
SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.Q31841874
Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: a confocal microscopy studyQ32066263
Clearance of glutamate inside the synapse and beyondQ33680880
Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult miceQ33690272
Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in miceQ33769818
Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathwayQ33786509
Norepinephrine controls astroglial responsiveness to local circuit activity.Q33841781
Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damageQ33853378
GLIA: listening and talking to the synapseQ33938676
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticusQ34048890
Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathwaysQ34067313
Astrocyte proliferation following stroke in the mouse depends on distance from the infarctQ34087948
Reactive astrocytes: cellular and molecular cues to biological functionQ41673434
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentinQ41782223
Evaluation of TRAP-sequencing technology with a versatile conditional mouse model.Q41892926
Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous systemQ42012887
Brain metabolism dictates the polarity of astrocyte control over arteriolesQ42089441
Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathwaysQ42159928
Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice.Q42256407
Signaling at the gliovascular interface.Q42451204
The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstructionQ42471480
Activation of the JAK/STAT pathway following transient focal cerebral ischemia: signaling through Jak1 and Stat3 in astrocytesQ42486284
In vitro ischemia promotes calcium influx and intracellular calcium release in hippocampal astrocytes.Q42516612
Application of a translational profiling approach for the comparative analysis of CNS cell typesQ42585641
Ca(2+) signaling in astrocytes and its role in ischemic strokeQ42737185
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytesQ42739394
NG2 cells are not a major source of reactive astrocytes after neocortical stab wound injuryQ42977404
Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes.Q43069939
Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responsesQ44041786
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation.Q44240672
Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemiaQ44278548
Time-course phosphorylation of the mitogen activated protein (MAP) kinase group of signalling proteins and related molecules following middle cerebral artery occlusion (MCAO) in ratsQ44380550
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemiaQ44560865
Intermediate filaments are important for astrocyte response to oxidative stress induced by oxygen-glucose deprivation and reperfusionQ44587135
Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors.Q45038421
Calcium transients in astrocyte endfeet cause cerebrovascular constrictionsQ45051047
Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathwayQ45270341
SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathwayQ45839227
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].Q45985961
A neurovascular niche for neurogenesis after stroke.Q46011312
Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.Q46024282
Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic strokeQ46187578
Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP miceQ46408158
Developmental profile and mechanisms of GABA-induced calcium signaling in hippocampal astrocytesQ46622479
Loss of astrocytic domain organization in the epileptic brain.Q46681558
In vivo calcium imaging reveals functional rewiring of single somatosensory neurons after strokeQ47613554
Up-regulation of Connexin43 in the glial scar following photothrombotic ischemic injuryQ48248130
Accelerated glial reactivity to stroke in aged rats correlates with reduced functional recoveryQ48261980
Transforming growth factor-beta 1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivoQ48298841
Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1.Q48338096
Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia.Q48343734
Inflammation and glial responses in ischemic brain lesionsQ48381768
Activation of mitogen-activated protein kinases in experimental cerebral ischemiaQ48435246
Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemiaQ48449881
Astrocyte morphology after ischemic and hemorrhagic experimental stroke has no influence on the different recovery patternsQ48485534
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouseQ48491021
GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation densityQ48498547
Astrocytic Ca2+ signaling evoked by sensory stimulation in vivoQ48540425
High sensitivity of protoplasmic cortical astroglia to focal ischemia.Q48663800
Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress?Q48824445
Phosphorylation of signal transducer and activator of transcription-3 (Stat3) after focal cerebral ischemia in ratsQ48831699
Monitoring the temporal and spatial activation pattern of astrocytes in focal cerebral ischemia using in situ hybridization to GFAP mRNA: comparison with sgp-2 and hsp70 mRNA and the effect of glutamate receptor antagonistsQ48892077
Induction of phosphorylated-Stat3 following focal cerebral ischemia in miceQ48900686
Freshly isolated astrocytes from rat hippocampus show two distinct current patterns and different [K(+)](o) uptake capabilitiesQ49162446
Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia.Q50670391
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.Q50726567
Astrocytic Ca(2+) waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia.Q50966034
Protective Role of Reactive Astrocytes in Brain IschemiaQ57779641
A Transforming Growth Factor-β Antagonist Unmasks the Neuroprotective Role of This Endogenous Cytokine in Excitotoxic and Ischemic Brain InjuryQ60597724
Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humansQ71062171
Transforming growth factor-beta 1 exhibits delayed gene expression following focal cerebral ischemiaQ72254715
Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the ratQ73800967
Spatiotemporal dynamics of astroglial and microglial responses after photothrombotic stroke in the rat brainQ81358800
Reactive oxygen species scavenger inhibits STAT3 activation after transient focal cerebral ischemia-reperfusion injury in ratsQ83984440
Inhibition of the group I mGluRs reduces acute brain damage and improves long-term histological outcomes after photothrombosis-induced ischaemiaQ37206018
Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathwayQ37226465
Targeted activation of astrocytes: a potential neuroprotective strategy.Q37302851
α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving miceQ37381408
The bright side of the glial scar in CNS repairQ37396812
In vivo astrocytic Ca(2+) signaling in health and brain disordersQ37414788
Heterogeneity in astrocyte morphology and physiologyQ37652218
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease modelQ37668698
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.Q37693974
Heterogeneity of reactive astrocytesQ37700124
Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke.Q37704935
Astrocyte heterogeneity: an underappreciated topic in neurobiologyQ37775248
Signaling pathways in reactive astrocytes, a genetic perspectiveQ37828480
The stem cell potential of glia: lessons from reactive gliosisQ37830315
Does the endogenous neurogenic response alter behavioral recovery following stroke?Q37930183
Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects.Q38017625
Astrogliosis as a therapeutic target for neurodegenerative diseases.Q38181295
Reactive gliosis and the multicellular response to CNS damage and disease.Q38181737
Glial cells as progenitors and stem cells: new roles in the healthy and diseased brainQ38225513
Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2.Q38523313
Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of genderQ39128180
CD36 is involved in astrocyte activation and astroglial scar formationQ39363205
Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysisQ40284616
GFAP knockout mice have increased levels of GDNF that protect striatal neurons from metabolic and excitotoxic insultsQ40647866
Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke modelQ40660882
Transforming growth factor-beta1 as a regulator of the serpins/t-PA axis in cerebral ischemiaQ40938635
Neuronal protective role of PBEF in a mouse model of cerebral ischemiaQ41185582
Photothrombosis ischemia stimulates a sustained astrocytic Ca2+ signaling in vivoQ41449352
Mechanisms and functions of p38 MAPK signalling.Q34125736
Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemiaQ34165111
Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transductionQ34172458
Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivoQ34233464
Glutamate transporters bring competition to the synapse.Q34326642
In vivo conversion of astrocytes to neurons in the injured adult spinal cordQ34406755
Mitogen-activated protein kinases and cerebral ischemiaQ34408217
Ischemic stroke therapy.Q34511600
Object-based analysis of astroglial reaction and astrocyte subtype morphology after ischemic brain injuryQ34675645
Neurogenesis and inflammation after ischemic stroke: what is known and where we go from hereQ34727139
Cerebral blood flow modulation by Basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes.Q34778937
Beneficial effects of gfap/vimentin reactive astrocytes for axonal remodeling and motor behavioral recovery in mice after strokeQ35018701
Biochemistry of ischemic stroke.Q35132798
Astrocyte influences on ischemic neuronal death.Q35699525
PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemiaQ35738314
Proliferating reactive astrocytes are regulated by Notch-1 in the peri-infarct area after strokeQ35747979
Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injuryQ35768729
Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after strokeQ36100566
Astrocytes in cerebral ischemic injury: morphological and general considerationsQ36104657
Role of glial cells in cerebral ischemiaQ36104660
Notch signaling in the mammalian central nervous system: insights from mouse mutantsQ36140085
Involvement of mitogen-activated protein kinase pathways in expression of the water channel protein aquaporin-4 after ischemia in rat cortical astrocytesQ36208302
MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefitsQ36273853
Genomic analysis of reactive astrogliosisQ36344611
Glutamate-dependent neuroglial calcium signaling differs between young and adult brainQ36600321
P2Y1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouseQ36745122
GFP imaging of live astrocytes: regional differences in the effects of ischaemia upon astrocytesQ36831112
The role of JAK-STAT signaling within the CNS.Q36895415
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injuryQ36974841
In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increaseQ37017529
Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injuryQ37058141
Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemiaQ37117308
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purificationQ37191961
P407language of work or nameEnglishQ1860
P921main subjectastrocyteQ502961
P304page(s)234-44
P577publication date2016-01-01
P1433published inNeurobiology of DiseaseQ15716606
P1476titleReactive astrocytes and therapeutic potential in focal ischemic stroke
P478volume85

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cites work (P2860)
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