A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

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A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines is …
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P819ADS bibcode2010PLoSO...5.9001H
P356DOI10.1371/JOURNAL.PONE.0009001
P3181OpenCitations bibliographic resource ID606809
P932PMC publication ID2814859
P698PubMed publication ID20126405
P5875ResearchGate publication ID41401410

P2093author name stringSharon L Aukerman
Yuhong Ning
Kyle J MacBeth
Michelle Williams
Carla Heise
Helen Brady
Normand Richard
Paul W Hollenbach
Aaron N Nguyen
Leslie Krushel
P2860cites workEfficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III studyQ24563021
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Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized studyQ28301602
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signalQ28384242
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.Q34128471
Biological effects of 5-azacytidine in eukaryotesQ34202821
Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemiaQ34659942
Epigenetic therapy of cancer: past, present and futureQ36399557
Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell linesQ37066258
DNA methyltransferase inhibitors: class effect or unique agents?Q37132879
Azacitidine for the treatment of myelodysplastic syndromeQ37546018
Biochemistry of azacitidine: a review.Q38179013
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cellsQ39887368
Azacytidine causes complex DNA methylation responses in myeloid leukemiaQ39940031
The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myelomaQ39987415
p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.Q40020060
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.Q40054309
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.Q40118609
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.Q40309778
5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia.Q40479015
Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathwayQ44512459
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Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation foQ48693524
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Immunosuppressive effects of methylglyoxal-bis(guanylhydrazone) on mouse bone marrow and spleen cells and their antagonism by spermidineQ67016496
The mechanism of inhibition of protein synthesis by 5-azacytidine in HeLa cellsQ70004129
Characterization of polyribosomes and maturation of ribosomal RNA in hepatoma cells treated with 5-azacytidineQ70024413
Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemiaQ71611069
Comparison of the antileukemic activity of 5-AZA-2'-deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-azacytidine against L1210 leukemiaQ72378355
Mechanism of 5-azacytidine-induced transfer RNA cytosine-5-methyltransferase deficiencyQ72611418
The effect of 5-azadeoxycytidine on cell growth and DNA methylationQ72672747
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agentsQ72800599
Effect of cytarabine and decitabine in combination in human leukemic cell linesQ80624812
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
acute myeloid leukemiaQ264118
P304page(s)e9001
P577publication date2010-02-02
P1433published inPLOS OneQ564954
P1476titleA comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
P478volume5