Ameliorated ConA-induced hepatitis in the absence of PKC-theta

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Ameliorated ConA-induced hepatitis in the absence of PKC-theta is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...731174F
P356DOI10.1371/JOURNAL.PONE.0031174
P3181OpenCitations bibliographic resource ID2591339
P932PMC publication ID3274545
P698PubMed publication ID22347449
P5875ResearchGate publication ID221844851

P2093author name stringJian Ma
Yan Ding
Weirong Shang
Xianfeng Fang
Zuoming Sun
Ruiqing Wang
P2860cites workRequirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in miceQ73535883
Essential pathogenetic role for interferon (IFN-)gamma in concanavalin A-induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion proteinQ73774662
Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expressionQ78431138
Discovery of potent and selective PKC-theta inhibitorsQ79285371
The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosisQ79445145
Methods for detection, isolation and culture of mouse and human invariant NKT cellsQ80487867
The transcription factor PLZF directs the effector program of the NKT cell lineageQ24654999
The biology of NKT cellsQ28277482
Protein kinase C theta affects Ca2+ mobilization and NFAT cell activation in primary mouse T cellsQ28590075
Selective function of PKC-theta in T cellsQ28647196
Signal transduction by lymphocyte antigen receptorsQ29619894
Efficient isolation of mouse liver NKT cells by perfusionQ33565606
Pathogenesis of autoimmune hepatitisQ33698264
Protein kinase Ctheta: a new essential superstar on the T-cell stageQ34091319
NKT cells: facts, functions and fallacies.Q34091324
CD1-specific T cells in microbial immunityQ34332693
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.Q35056090
The PKC gene module: molecular biosystematics to resolve its T cell functionsQ35096678
NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-thetaQ35111008
Liver NKT cells: an account of heterogeneityQ35177706
A T cell-dependent experimental liver injury in mice inducible by concanavalin AQ35603939
Regulation of liver inflammatory injury by signal transducer and activator of transcription-6.Q35745916
Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.Q35795137
To be or not to be NKT: natural killer T cells in the liver.Q35919440
Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytesQ36365532
Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancerQ36949589
The role of stem cells in vein graft remodellingQ36979430
Structure-based optimization of PKCtheta inhibitorsQ36979540
SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathwayQ37259298
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activationQ37358144
PKC-θ is a Drug Target for Prevention of T Cell-Mediated Autoimmunity and Allograft RejectionQ37798037
Bile acids up-regulate death receptor 5/TRAIL-receptor 2 expression via a c-Jun N-terminal kinase-dependent pathway involving Sp1.Q38349203
Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase betaQ39452298
Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytesQ40018644
Kinetics of tumour necrosis factor-alpha, soluble tumour necrosis factor receptors, interleukin 1-beta and its receptor antagonist during serious infectionsQ40569186
Augmentation of Valpha14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitisQ42157047
Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicityQ42409618
Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell developmentQ42944908
Diagnosis and treatment of autoimmune hepatitisQ44080061
Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B.Q47810582
The roles of intrahepatic Valpha14(+) NK1.1(+) T cells for liver injury induced by Salmonella infection in miceQ50126265
Assessment of lymphocyte development in radiation bone marrow chimeras.Q50634532
Immune phenotype of chronic liver disease.Q50864814
Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor.Q54185769
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.Q54697381
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytesQ58617364
Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T CellsQ62230390
Antitumor cytotoxicity mediated by ligand-activated human V alpha24 NKT cellsQ73121259
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)e31174
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleAmeliorated ConA-induced hepatitis in the absence of PKC-theta
P478volume7

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cites work (P2860)
Q386580931-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) reduces hepatic injury in concanavalin A-treated mice.
Q86597896CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production
Q28079616Diacylglycerol Kinases in T Cell Tolerance and Effector Function
Q36346954Divergent effects of RIP1 or RIP3 blockade in murine models of acute liver injury.
Q37579232Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice
Q41890374Intervention of PKC-θ as an immunosuppressive regimen
Q41648587Mincle Signaling Promotes Con A Hepatitis
Q96289890Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice
Q33809437Pharmacological Inhibition of PKCθ Counteracts Muscle Disease in a Mouse Model of Duchenne Muscular Dystrophy
Q36981856Regulation of Lipid Signaling by Diacylglycerol Kinases during T Cell Development and Function
Q27024068The Novel PKCθ from Benchtop to Clinic
Q56378345The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?
Q37520009The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression

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