Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection

scientific article

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1002511
P3181OpenCitations bibliographic resource ID3415418
P932PMC publication ID3280978
P698PubMed publication ID22359499
P5875ResearchGate publication ID221855992

P50authorMeera UnnikrishnanQ63860319
Eric RubinQ29887908
P2093author name stringAlfred L Goldberg
Olga Kandror
Ravikiran M Raju
Vidhya Krishnamoorthy
Daniel H F Rubin
Tatos N Akopian
P2860cites workThe ubiquitin-proteasome proteolytic pathway: destruction for the sake of constructionQ24292709
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1Q27643627
The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysisQ27748258
Genes required for mycobacterial growth defined by high density mutagenesisQ27976512
Cytoplasmic degradation of ssrA-tagged proteins.Q50756525
Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosisQ28486486
ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophageQ28486713
Mycobacterium tuberculosis ftsH expression in response to stress and viabilityQ28486955
Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosisQ28487392
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxideQ28487442
Cell cycle control by an essential bacterial two-component signal transduction proteinQ29346643
Protein degradation and protection against misfolded or damaged proteinsQ29618400
Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin).Q30408156
Controlled degradation by ClpXP protease tunes the levels of the excision repair protein UvrA to the extent of DNA damageQ33841737
Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substratesQ33876875
An essential protease involved in bacterial cell-cycle controlQ33889602
Mode of action of chloramphenicol. III. Action of chloramphenicol on bacterial energy metabolismQ33972183
Stress-induced ClpP serine protease of Listeria monocytogenes is essential for induction of listeriolysin O-dependent protective immunity.Q34008601
A multiple-component, ATP-dependent protease from Escherichia coliQ34183368
Emerging principles in protease-based drug discoveryQ34282102
Escherichia coli contains a soluble ATP-dependent protease (Ti) distinct from protease La.Q34336717
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled proteaseQ34615400
Depletion of antibiotic targets has widely varying effects on growthQ34651942
Broad yet high substrate specificity: the challenge of AAA+ proteinsQ35705299
Lon and Clp family proteases and chaperones share homologous substrate-recognition domainsQ36378628
Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteriaQ36736444
Proteases in bacterial pathogenesisQ37602770
Effects of production of abnormal proteins on the rate of killing of Escherichia coli by streptomycinQ39815632
Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approachQ41849520
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic proteaseQ42740574
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.Q44563531
Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureusQ46321774
Mycobacterial recombineeringQ47814886
The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenesQ47870369
ClpP participates in the degradation of misfolded protein in Lactococcus lactisQ47988611
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectMycobacterium tuberculosisQ130971
P304page(s)e1002511
P577publication date2012-02-16
P1433published inPLOS PathogensQ283209
P1476titleMycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection
P478volume8

Reverse relations

cites work (P2860)
Q34385523A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp.
Q41050594AAA+ Machines of Protein Destruction in Mycobacteria
Q89826547Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in vitro
Q38829284Acyldepsipeptide antibiotics as a potential therapeutic agent against Clostridium difficile recurrent infections
Q40776051Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
Q89983079An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR
Q27314706An essential nonredundant role for mycobacterial DnaK in native protein folding
Q42709358Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase
Q36243182Attenuated Actinobacillus pleuropneumoniae double-deletion mutant S-8∆clpP/apxIIC confers protection against homologous or heterologous strain challenge
Q39023951Bacterial proteases, untapped antimicrobial drug targets
Q38047828Bacterial proteolytic complexes as therapeutic targets
Q33607221Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.
Q55379024Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related organisms.
Q37282173Chromosomal rearrangements and protein globularity changes in Mycobacterium tuberculosis isolates from cerebrospinal fluid
Q35536311Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity
Q34371280Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis
Q58558556Clostridium difficile ClpP Homologs are Capable of Uncoupled Activity and Exhibit Different Levels of Susceptibility to Acyldepsipeptide Modulation
Q64955662ClpP Protease, a Promising Antimicrobial Target.
Q42595177Comparative genomic analysis of twelve Streptococcus suis (pro)phages
Q92372002Comparative proteomics analysis between biofilm and planktonic cells of Mycobacterium tuberculosis
Q93067396Consequences of the loss of catalytic triads in chloroplast CLPPR protease core complexes in vivo
Q34442361Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery
Q64118325Defining the Transcriptional and Post-transcriptional Landscapes of in Aerobic Growth and Hypoxia
Q90450055Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis
Q39019430Development of new antituberculosis drugs from natural products
Q54229844Domains within RbpA serve specific functional roles that regulate the expression of distinct mycobacterial gene subsets.
Q40422721Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.
Q41927049Enabling faster Go/No-Go decisions through secondary screens in anti-mycobacterial drug discovery
Q33709564Enhanced specialized transduction using recombineering in Mycobacterium tuberculosis
Q38195069Genomic tools to profile antibiotic mode of action.
Q51607347Inhibitory Effect of Camptothecin against Rice Bacterial Brown Stripe Pathogen Acidovorax avenae subsp. avenae RS-2.
Q92949154Insights to the Assembly of a Functionally Active Leptospiral ClpP1P2 Protease Complex along with Its ATPase Chaperone ClpX
Q36569233Integration-dependent bacteriophage immunity provides insights into the evolution of genetic switches
Q27682707Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
Q38660358Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines
Q37703346Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease
Q64289426Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase
Q34656348Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities
Q36492775Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis.
Q28538895Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2
Q38949083Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages.
Q27675886Mycobacterium tuberculosis RsdA provides a conformational rationale for selective regulation of  -factor activity by proteolysis
Q47395522New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State
Q91807571New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
Q35113287Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis.
Q47576680Proteases and protease inhibitors in infectious diseases
Q38103940Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets
Q35038408Protein-coding housekeeping gene Rv2461c can be used as an amplification target in loop-mediated isothermal amplification assay for the detection of Mycobacterium tuberculosis in sputum samples
Q38600486RETRACTED: Targeting Mycobacterial Enzymes with Natural Products
Q38547127Recently disclosed chemical entities as potential candidates for management of tuberculosis
Q34626585Regulated Expression Systems for Mycobacteria and Their Applications
Q57751886Reversible inhibition of the ClpP protease via an N-terminal conformational switch
Q47118931Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells
Q27679912Structural Basis of Mycobacterial Inhibition by Cyclomarin A
Q27678774Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad
Q36755029Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis
Q42788863Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase
Q34624840Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis
Q35620201Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria
Q39149038Targeting Phenotypically Tolerant Mycobacterium tuberculosis
Q52692190Targeting the Proteostasis Network for Mycobacterial Drug Discovery.
Q92533100The ADEP Biosynthetic Gene Cluster in Streptomyces hawaiiensis NRRL 15010 Reveals an Accessory clpP Gene as a Novel Antibiotic Resistance Factor
Q34531740The C-terminus of ClpC1 of Mycobacterium tuberculosis is crucial for its oligomerization and function
Q34551568The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae
Q35002980The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy
Q35620145The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
Q36888447The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host
Q26795478The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis
Q35106042The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo
Q90425706The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci
Q33601825Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome
Q40746718Two ways to skin a cat: acyldepsipeptides antibiotics can kill bacteria through activation or inhibition of ClpP activity
Q38053069Virulence factors of the Mycobacterium tuberculosis complex