Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes

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Deletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PNTD.0001968
P3181OpenCitations bibliographic resource ID1372194
P932PMC publication ID3531514
P698PubMed publication ID23301106
P5875ResearchGate publication ID234090706

P50authorJudith AllenQ33991231
Simon A BabayanQ43090599
P2093author name stringDavid W Taylor
Honglin Luo
Nick Gray
P2860cites workOf mice, cattle, and humans: the immunology and treatment of river blindnessQ21144551
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Drastic reduction of a filarial infection in eosinophilic interleukin-5 transgenic miceQ30872052
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The larval specific lymphatic filarial ALT-2: induction of protection using protein or DNA vaccinationQ31136230
Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stagesQ33246334
Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivityQ33531929
The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasisQ33598028
Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine developmentQ33600663
Granuloma Formation around Filarial Larvae Triggered by Host Responses to an Excretory/Secretory AntigenQ33747318
Phenotypic evidence of emerging ivermectin resistance in Onchocerca volvulusQ33863602
Wild immunologyQ34164810
High-efficiency gene transfer into skeletal muscle mediated by electric pulsesQ35123357
Helminth parasites--masters of regulationQ35884205
The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responsesQ35951849
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Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identifiedQ36367631
The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cellsQ36489528
Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationshipQ37076723
Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity.Q37253393
Lymphocyte hyporesponsiveness during filarial nematode infectionQ37257681
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Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice.Q38686842
The Secreted Larval Acidic Proteins (SLAPs) of Onchocerca spp. are encoded by orthologues of the alt gene family of Brugia malayi and have host protective potential.Q39605690
Recruitment and expansion of dendritic cells in vivo potentiate the immunogenicity of plasmid DNA vaccines.Q40247465
Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae.Q40469874
Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.Q40812914
Brugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird modelQ41962135
In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3+ T cellsQ43040798
Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP.Q43812639
Bancroftian filariasis: house-to-house variation in the vectors and transmission -- and the relationship to human infection -- in an endemic community of coastal Tanzania.Q43946138
Relationships between Wuchereria bancrofti microfilaria counts in human blood and parasite uptake and maturation in Culex pipiens, with observations on the effects of diethylcarbamazine treatment on these parameters.Q44150674
Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).Q44830476
Characterization of an Onchocerca volvulus L3-specific larval antigen, Ov-ALT-1.Q48001840
Comparison of immunogenicity, protective efficacy of single and cocktail DNA vaccine of Brugia malayi abundant larval transcript (ALT-2) and thioredoxin peroxidase (TPX) in mice.Q50778870
An analysis of the population genetics of potential multi-drug resistance in Wuchereria bancrofti due to combination chemotherapy.Q50799176
Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection.Q51667891
A combination of two Brugia malayi filarial vaccine candidate antigens (BmALT-2 and BmVAH) enhances immune responses and protection in jirds.Q51770083
Optimization of DNA vaccination against cutaneous leishmaniasis.Q52009810
Long-term, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle.Q52180788
Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection.Q52553534
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccinesQ56897738
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivoQ56902877
Lack of Fc-epsilon receptors on murine eosinophils: implications for the functional significance of elevated IgE and eosinophils in parasitic infectionsQ73358715
Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequencesQ80412140
Cysteine proteases as potential antigens in antiparasitic DNA vaccinesQ84335650
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectinfectious diseaseQ18123741
P304page(s)e1968
P577publication date2012-12-27
P1433published inPLoS Neglected Tropical DiseasesQ3359737
P1476titleDeletion of parasite immune modulatory sequences combined with immune activating signals enhances vaccine mediated protection against filarial nematodes
P478volume6

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cites work (P2860)
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