Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation

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Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation is …
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P819ADS bibcode2012PLoSO...748387O
P356DOI10.1371/JOURNAL.PONE.0048387
P3181OpenCitations bibliographic resource ID1439317
P932PMC publication ID3498306
P698PubMed publication ID23155382
P5875ResearchGate publication ID233424432

P50authorUlrike SteckelingsQ55221665
Björn DahlöfQ47156424
P2093author name stringMasatsugu Horiuchi
Masaki Mogi
Jun Iwanami
Li-Juan Min
Akiyoshi Ogimoto
Jitsuo Higaki
Fei Jing
Kana Tsukuda
Kousei Ohshima
Tomas Unger
P2860cites workFetuin-null mice are protected against obesity and insulin resistance associated with aging.Q51488607
Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?Q54506199
A noninvasive computerized tail-cuff system for measuring blood pressure in miceQ72210808
Renal actions of the selective angiotensin AT2 receptor ligands CGP 42112B and PD 123319 in the sodium-depleted ratQ72709558
Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cellsQ73054117
TNFalpha and leptin inhibit basal and glucose-stimulated insulin secretion and gene transcription in the HIT-T15 pancreatic cellsQ74156348
Tumor necrosis factor-alpha-activated cell death pathways in NIT-1 insulinoma cells and primary pancreatic beta cellsQ77932870
Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissueQ79696160
Roles of interleukin 17 in angiotensin II type 1 receptor-mediated insulin resistanceQ83069122
Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II.Q41431151
Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.Q42027895
Compound 21, the first orally active, selective agonist of the angiotensin type 2 receptor (AT2): implications for AT2 receptor research and therapeutic potentialQ43253857
Transcriptional suppression of type 1 angiotensin II receptor gene expression by peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cellsQ43646691
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cellsQ43785533
Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic miceQ44810052
Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat.Q44816727
AT2 receptor deficiency attenuates adipocyte differentiation and decreases adipocyte number in atherosclerotic mice.Q46011143
Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudyQ46388306
Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistanceQ46406520
Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activationQ46578517
Angiotensin II is associated with activation of NF-kappaB-mediated genes and downregulation of PPARsQ46599371
Blockade of AT1 receptor improves adipocyte differentiation in atherosclerotic and diabetic modelsQ46813413
Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetesQ46917054
Ventromedial hypothalamic stimulation enhances peripheral glucose uptake in anesthetized rats.Q48661229
Inflammation and insulin resistanceQ22241893
International union of pharmacology. XXIII. The angiotensin II receptorsQ28138041
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistanceQ29619774
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trialQ29619886
Adipokines in inflammation and metabolic diseaseQ29620456
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapyQ29620534
Identification and characterization of a functional mitochondrial angiotensin systemQ30427934
Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in miceQ30433043
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.Q31126656
Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formationQ31806569
Involvement of bradykinin and nitric oxide in leptin-mediated glucose uptake in skeletal muscle.Q31836112
Telmisartan, ramipril, or both in patients at high risk for vascular eventsQ33156143
Selective angiotensin II AT2 receptor agonists: arylbenzylimidazole structure-activity relationshipsQ33264567
Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trialQ33999757
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenololQ34522261
Effects of valsartan compared to amlodipine on preventing type 2 diabetes in high-risk hypertensive patients: the VALUE trial.Q34541234
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trialQ34766176
Angiotensin AT2 receptors: cardiovascular hope or hype?Q35045801
The many faces of PPARgammaQ36344625
The physiology of a local renin-angiotensin system in the pancreasQ36705812
The role of peroxisome proliferator‐activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitusQ37150550
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiencyQ37175466
Angiotensin II and the development of insulin resistance: implications for diabetesQ37371106
The angiotensin AT2 receptor in left ventricular hypertrophyQ37786172
A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activityQ38361522
Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic controlQ39905953
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
type 2 diabetesQ3025883
preproinsulinQ7240673
P304page(s)e48387
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleDirect angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation
P478volume7