A potential peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptor

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A potential peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptor is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...749702B
P356DOI10.1371/JOURNAL.PONE.0049702
P932PMC publication ID3499488
P698PubMed publication ID23166750
P5875ResearchGate publication ID233725662

P2093author name stringYibang Chen
Ravi Iyengar
Aislyn D W Boran
Shan Zhao
Gomathi Jayaraman
Joseph Seco
Sushmitha Reddy
Vinodh Jayaraman
P2860cites workApoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.Q53711865
Cholera toxin stimulation of human mammary epithelial cells in cultureQ72950883
Deciphering the mammalian stress response - a stressful taskQ73171142
Expression of c-erbB receptors, heregulin and oestrogen receptor in human breast cell linesQ74081713
Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR(622-660) and its interaction with Ca2+/calmodulinQ79247495
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentQ24309071
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
The Juxtamembrane Region of the EGF Receptor Functions as an Activation DomainQ27646344
EGFR mutation and resistance of non-small-cell lung cancer to gefitinibQ27824829
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximabQ27851587
An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activationQ33733313
Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapyQ33943421
Understanding resistance to EGFR inhibitors-impact on future treatment strategiesQ34088424
p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapyQ35039999
Variants of 3T3 cells lacking mitogenic response to epidermal growth factorQ35051611
Human epithelial cell immortalization as a step in carcinogenesisQ35131789
Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activationQ35762279
Transmembrane peptides as inhibitors of ErbB receptor signalingQ35919443
Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movementQ36234800
Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activationQ36288511
ErbB2 expression increases the spectrum and potency of ligand-mediated signal transduction through ErbB4.Q36490427
An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) familyQ36493654
Targeting the EGFR pathway for cancer therapyQ36683460
EGFR family: structure physiology signalling and therapeutic targetsQ37272623
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancerQ37274280
Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extractQ37565967
EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitorsQ37634595
KRAS and BRAF: drug targets and predictive biomarkersQ37815135
Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissueQ38581899
p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.Q39896361
Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.Q40099043
Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell linesQ40106465
Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cellsQ40408766
Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling.Q40419018
Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo.Q42806142
The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site.Q42832751
The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF bindingQ43131495
Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation.Q43732514
A basic peptide within the juxtamembrane region is required for EGF receptor dimerizationQ45149243
Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptorsQ46175993
Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans.Q47448961
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e49702
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleA potential peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptor
P478volume7

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cites work (P2860)
Q52689258A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity.
Q64278999A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation
Q38970301Inhibiting epidermal growth factor receptor at a distance
Q36698771Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation.
Q30398451Targeting kinase signaling pathways with constrained peptide scaffolds

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