Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation

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Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...854677Z
P356DOI10.1371/JOURNAL.PONE.0054677
P932PMC publication ID3559867
P698PubMed publication ID23382939
P5875ResearchGate publication ID235402860

P2093author name stringDominique N Soroka
Huadong Chen
Renaud F Warin
Shengmin Sang
Yingdong Zhu
P2860cites workTotal synthesis of serofendic acids A and B employing tin-free homoallyl-homoallyl radical rearrangementQ81109514
Fruit and vegetables and cancer riskQ22251000
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stressQ28385954
Cancer chemoprevention with dietary phytochemicalsQ29617743
A critical evaluation of the application of biomarkers in epidemiological studies on diet and healthQ34345131
Metabolism of [6]-shogaol in mice and in cancer cellsQ35846908
Bioavailability of phenolic compoundsQ35992009
The chemopreventive agent development research program in the Division of Cancer Prevention of the US National Cancer Institute: an overviewQ36187498
Bioactive food components and cancer risk reductionQ37037533
The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective.Q37152932
Harnessing the fruits of nature for the development of multi-targeted cancer therapeuticsQ37442309
Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols.Q37442563
Update on the chemopreventive effects of ginger and its phytochemicalsQ37934980
Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a reviewQ38006053
An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe).Q38010489
Cytotoxic components from the dried rhizomes of Zingiber officinale RoscoeQ39986613
6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in miceQ43119184
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e54677
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titleMetabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation
P478volume8

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cites work (P2860)
Q903813606-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential
Q410512766-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells
Q38902044A comparative study of Zingiber officinale Roscoe pulp and peel: phytochemical composition and evaluation of antitumour activity
Q28547152Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death
Q37158063Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice
Q39939944Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells
Q90040038Effect of 6-Shogaol on the Glucose Uptake and Survival of HT1080 Fibrosarcoma Cells
Q34249763Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo
Q92502914Gingers and Their Purified Components as Cancer Chemopreventative Agents
Q37697336Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.

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