Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy

scientific journal article

Smoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.270397
P932PMC publication ID3173130
P698PubMed publication ID21771785

P50authorSzabolcs LengyelQ113009661
P2093author name stringRachid Safi
Khaldon Bodoor
Beata Lontay
David Loiselle
Donald P. McDonnell
Douglas H. Weitzel
Timothy A. Haystead
Zhengzheng Wei
P2860cites workNull mutation of the prolactin receptor gene produces multiple reproductive defects in the mouseQ24315716
Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscleQ24319199
Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancyQ24338836
The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor bindingQ24554243
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and BQ24556548
The prolactin and growth hormone families: pregnancy-specific hormones/cytokines at the maternal-fetal interfaceQ24792242
Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxationQ27650597
A signature motif in transcriptional co-activators mediates binding to nuclear receptorsQ27860938
Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at termQ28177087
Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cellsQ28237585
Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterusQ28511804
Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the ratQ28567153
Mammalian target of rapamycin is activated in association with myometrial proliferation during pregnancyQ28578365
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoformQ28586470
Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cellsQ28771752
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalitiesQ29615568
Steroid hormone receptors: many actors in search of a plotQ29618397
Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinasesQ30167936
Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteinsQ30434302
Neonatal complications following preterm birthQ31143063
The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptorQ31168538
p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1).Q33642227
Retinoic acid metabolizing enzyme CYP26A1 is implicated in rat embryo implantationQ33715909
The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single geneQ33766903
Mapping and functional characterization of the murine smoothelin-like 1 promoterQ33830223
Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin geneQ33887784
Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptorQ33888599
miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and laborQ34375717
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspectsQ34411334
The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.Q34466960
Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout miceQ34471721
The management of preterm laborQ34992754
A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturitionQ35234835
Regulation of signal transduction pathways by estrogen and progesteroneQ36041030
Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.Q36372631
The molecular control of corpus luteum formation, function, and regression.Q36640635
ParturitionQ36710647
Steroid hormone control of myometrial contractility and parturitionQ36871331
Myosin phosphatase target subunit: Many roles in cell functionQ37044074
Implication of ADAM-8, -9, -10, -12, -15, -17, and ADAMTS-1 in implantational remodeling of a mouse uterusQ37205649
The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressorQ37229683
Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labourQ37418427
Progesterone Receptors in the Human Pregnancy Uterus: Do they Hold the Key to Birth Timing?Q37796506
Retinoic acid-metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: functional study of its role in early pregnancyQ38346850
8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding proteinQ39456804
Prolactins of pregnancy and their cellular source.Q39518601
Parturition.Q39752705
Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A.Q40162676
Phosphorylation and progesterone receptor function.Q40455187
Identification and characterization of the protein-associated splicing factor as a negative co-regulator of the progesterone receptor.Q40466349
Human labour is associated with nuclear factor-kappaB activity which mediates cyclo-oxygenase-2 expression and is involved with the 'functional progesterone withdrawal'.Q43625477
Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometriumQ44018214
Tumor necrosis factor-alpha suppresses the expression of steroid receptor coactivator-1 and -2: a possible mechanism contributing to changes in steroid hormone responsivenessQ44961981
Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulationQ45230684
Myometrial apoptosis: activation of the caspase cascade in the pregnant rat myometrium at midgestationQ46890565
Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones.Q54583343
The LxxLL motif: a multifunctional binding sequence in transcriptional regulationQ58484404
Progestin represses human connexin43 gene expression similarly in primary cultures of myometrial and uterine leiomyoma cellsQ71602597
Steroid hormone regulation of rat myometrial gap junction formation: effects on cx43 levels and traffickingQ72251991
Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient miceQ73310168
Effects of RU486 on estrogen, progesterone, oxytocin, and their receptors in the rat uterus during late gestationQ73456741
Expression and regulation of the messenger ribonucleic acid encoding the prostaglandin F(2alpha) receptor in the rat myometrium during pregnancy and laborQ73675268
Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoformQ74281193
Changes in expression of contractile FP and relaxatory EP2 receptors in pregnant rat myometrium during late gestation, at labor, and postpartumQ77328787
Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) miceQ78086480
ROCK1 phosphorylates and activates zipper-interacting protein kinaseQ79422103
Cyclic GMP regulation of myosin phosphatase: a new piece for the puzzle?Q81364648
P433issue36
P407language of work or nameEnglishQ1860
P921main subjectSmoothelin-like 1Q21990634
P304page(s)31839–31851
P577publication date2011-09-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleSmoothelin-like 1 protein is a bifunctional regulator of the progesterone receptor during pregnancy
P478volume286

Reverse relations

cites work (P2860)
Q36315187Binding of smoothelin-like 1 to tropomyosin and calmodulin is mutually exclusive and regulated by phosphorylation
Q56929322In situ Analysis of Smoothelin-like 1 and Calmodulin Interactions in Smooth Muscle Cells by Proximity Ligation
Q35764304Lasting effects of early exposure to temperature on the gonadal transcriptome at the time of sex differentiation in the European sea bass, a fish with mixed genetic and environmental sex determination
Q38165311Novel contributions of the smoothelin-like 1 protein in vascular smooth muscle contraction and its potential involvement in myogenic tone
Q35859530Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice
Q34810890Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Krüppel-like Factor 9.
Q27693957Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility
Q61444196Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling

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