| scholarly article | Q13442814 |
| P2093 | author name string | D. L. St Germain | |
| M. J. Schneider | |||
| V. A. Galton | |||
| A. F. Parlow | |||
| S. E. Pallud | |||
| S. N. Fiering | |||
| P433 | issue | 12 | |
| P921 | main subject | Deiodinase, iodothyronine, type II | Q21496534 |
| phenotype | Q104053 | ||
| P304 | page(s) | 2137–2148 | |
| P577 | publication date | 2001-12-01 | |
| P1433 | published in | Molecular Endocrinology | Q3319475 |
| P1476 | title | Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4 | |
| P478 | volume | 15 |
| Q89980324 | A Direct Comparison of Thyroid Hormone Receptor Protein Levels in Mice Provides Unexpected Insights into Thyroid Hormone Action |
| Q92874891 | A Global Loss of Dio2 Leads to Unexpected Changes in Function and Fiber Types of Slow Skeletal Muscle in Male Mice |
| Q41773950 | A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. |
| Q36834971 | A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine |
| Q34062358 | A component of retinal light adaptation mediated by the thyroid hormone cascade |
| Q43872119 | A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. |
| Q30486616 | A protective role for type 3 deiodinase, a thyroid hormone-inactivating enzyme, in cochlear development and auditory function |
| Q27316795 | Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase |
| Q34132369 | Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis |
| Q34590252 | Action of thyroid hormone in brain |
| Q40246605 | Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage |
| Q57492869 | Amiodarone and the thyroid physiology, pathophysiology, diagnosis and management |
| Q37364530 | Animal models to study thyroid hormone action in cerebellum. |
| Q39859067 | Association of Type II 5' Monodeiodinase Thr92Ala Single Nucleotide Gene Polymorphism and Circulating Thyroid Hormones Among Type 2 Diabetes Mellitus Patients |
| Q37830366 | Bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance |
| Q24648381 | Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling |
| Q37657837 | Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions. |
| Q38908447 | Characterization of the UGA-recoding and SECIS-binding activities of SECIS-binding protein 2 |
| Q40535627 | Cinnamon intake reduces serum T3 level and modulates tissue-specific expression of thyroid hormone receptor and target genes in rats. |
| Q44030671 | Clinical and genetic characteristics of a large monocentric series of patients affected by thyroid hormone (Th) resistance and suggestions for differential diagnosis in patients without mutation of Th receptor β. |
| Q37379565 | Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X). |
| Q55645372 | Concurrent TSHR mutations and DIO2 T92A polymorphism result in abnormal thyroid hormone metabolism. |
| Q36733398 | Coordination of hypothalamic and pituitary T3 production regulates TSH expression |
| Q35986091 | Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T₃in the mouse cerebral cortex. |
| Q36424622 | Defending plasma T3 is a biological priority |
| Q54976888 | Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice. |
| Q92502907 | Deiodinases and their intricate role in thyroid hormone homeostasis |
| Q24669858 | Deiodinases: implications of the local control of thyroid hormone action |
| Q50449752 | Deletion of the Thyroid Hormone-Activating Type 2 Deiodinase Rescues Cone Photoreceptor Degeneration but Not Deafness in Mice Lacking Type 3 Deiodinase |
| Q37309699 | Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway |
| Q36577265 | Dietary selenium and selenoprotein function. |
| Q34718631 | Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality |
| Q50469869 | Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. |
| Q36570545 | Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency |
| Q48447119 | Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary |
| Q24651457 | Endocrine-disrupting chemicals: an Endocrine Society scientific statement |
| Q36796615 | Epididymis expresses the highest 5'-deiodinase activity in the male reproductive system: kinetic characterization, distribution, and hormonal regulation |
| Q34501861 | Essential Role of GATA2 in the Negative Regulation of Type 2 Deiodinase Gene by Liganded Thyroid Hormone Receptor β2 in Thyrotroph |
| Q93121790 | Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches |
| Q36761575 | General background on the hypothalamic-pituitary-thyroid (HPT) axis |
| Q37073731 | Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase |
| Q36710816 | Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9. |
| Q26774730 | Homeostatic Control of the Thyroid-Pituitary Axis: Perspectives for Diagnosis and Treatment |
| Q37007964 | Hormone disruption by PBDEs in adult male sport fish consumers |
| Q48653909 | Hypothalamus-Pituitary-Thyroid Axis. |
| Q35427151 | Hypothyroidism and brain developmental players |
| Q89892581 | Impact of hyperthyroidism on cardiac hypertrophy |
| Q38538203 | Implementation of Functional Genomics for Bench-to-Bedside Transition in Osteoarthritis |
| Q57967619 | Increased thyroidal fat and goitrous hypothyroidism induced by interferon-gamma |
| Q26851758 | Inherited defects in thyroid hormone cell-membrane transport and metabolism |
| Q34392670 | Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment |
| Q37189394 | Iodothyronine deiodinase enzyme activities in bone. |
| Q34185690 | Life without the iodothyronine deiodinases |
| Q41928193 | Life without thyroxine to 3,5,3'-triiodothyronine conversion: studies in mice devoid of the 5'-deiodinases |
| Q42261935 | MKK6 controls T3-mediated browning of white adipose tissue |
| Q37295374 | Maternal thyroid hormones are transcriptionally active during embryo-foetal development: results from a novel transgenic mouse model |
| Q33940924 | Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity |
| Q44805474 | Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender |
| Q34932671 | Minireview: Defining the roles of the iodothyronine deiodinases: current concepts and challenges |
| Q56990436 | Mouse Models that Target Individual Selenoproteins |
| Q36281925 | Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development |
| Q36793594 | Multigenic control of thyroid hormone functions in the nervous system |
| Q34460050 | Mutations in SECISBP2 result in abnormal thyroid hormone metabolism |
| Q28203265 | Neurodevelopmental control by thyroid hormone receptors |
| Q37437148 | Novel insights into thyroid hormones from the study of common genetic variation |
| Q28382759 | Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression |
| Q33841948 | Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts |
| Q33882924 | Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. |
| Q36943500 | Physiological role and regulation of iodothyronine deiodinases: a 2011 update |
| Q37940289 | Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options |
| Q47563395 | Population correlations do not support the existence of set points for blood levels of calcium or glucose - a new model for homeostasis. |
| Q35446528 | Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China |
| Q37150455 | Quantitative trait loci associated with elevated thyroid-stimulating hormone in the Wistar-Kyoto rat. |
| Q55315620 | Regulation of T3 Availability in the Developing Brain: The Mouse Genetics Contribution. |
| Q28297247 | Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter |
| Q36946056 | Restoration of cardiac tissue thyroid hormone status in experimental hypothyroidism: a dose-response study in female rats |
| Q36773018 | Role of Thyroid Hormones in Skeletal Development and Bone Maintenance |
| Q38042504 | Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling |
| Q35621354 | Role of type 2 deiodinase in response to acute lung injury (ALI) in mice |
| Q26785400 | Scope and limitations of iodothyronine deiodinases in hypothyroidism |
| Q28585049 | Secisbp2 is essential for embryonic development and enhances selenoprotein expression |
| Q35846481 | Selenoprotein expression is essential in endothelial cell development and cardiac muscle function |
| Q50192080 | Selenoproteins and cardiovascular stress |
| Q36025659 | Selenoproteins and their impact on human health through diverse physiological pathways |
| Q56990448 | Selenoproteins in Nervous System Development, Function and Degeneration |
| Q27009087 | Selenoproteins in nervous system development and function |
| Q64045278 | Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain |
| Q41537862 | Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis |
| Q33901193 | The 5'-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone |
| Q42380341 | The Circadian Clock Gene Bmal1 Controls Thyroid Hormone-Mediated Spectral Identity and Cone Photoreceptor Function |
| Q35620655 | The Correlation between Polybrominated Diphenyl Ethers (PBDEs) and Thyroid Hormones in the General Population: A Meta-Analysis |
| Q89072561 | The Deiodinase Trio and Thyroid Hormone Signaling |
| Q39639483 | The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. |
| Q35038827 | The central effects of thyroid hormones on appetite |
| Q38013541 | The deiodinases and the control of intracellular thyroid hormone signaling during cellular differentiation. |
| Q33758295 | The distal sequence element of the selenocysteine tRNA gene is a tissue-dependent enhancer essential for mouse embryogenesis |
| Q41637712 | The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress |
| Q24626002 | The human selenoproteome: recent insights into functions and regulation |
| Q36761589 | The hypothalamic-pituitary-thyroid (HPT) axis in frogs and its role in frog development and reproduction |
| Q36956004 | The menace of endocrine disruptors on thyroid hormone physiology and their impact on intrauterine development |
| Q92461252 | The role of thyroglobulin in thyroid hormonogenesis |
| Q37158027 | The role of thyroid hormone and brown adipose tissue in energy homoeostasis |
| Q34982275 | The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism |
| Q33830119 | The syndrome of inherited partial SBP2 deficiency in humans |
| Q27006848 | The syndromes of reduced sensitivity to thyroid hormone |
| Q24670736 | The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue |
| Q37378437 | The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. |
| Q38838315 | Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development. |
| Q89620693 | Thyroid Hormone Hyposensitivity: From Genotype to Phenotype and Back |
| Q40116462 | Thyroid hormone activation in vascular smooth muscle cells is negatively regulated by glucocorticoid |
| Q38266872 | Thyroid hormone and the neuroglia: both source and target |
| Q34455047 | Thyroid hormone function in the rat testis |
| Q37290881 | Thyroid hormone replacement therapy: three 'simple' questions, complex answers |
| Q38218101 | Thyroid hormone role on cerebellar development and maintenance: a perspective based on transgenic mouse models |
| Q37689365 | Thyroid hormones, t3 and t4, in the brain |
| Q36573049 | Thyroxine-induced expression of pyroglutamyl peptidase II and inhibition of TSH release precedes suppression of TRH mRNA and requires type 2 deiodinase |
| Q90327705 | Tolerance to Selenoprotein Loss Differs between Human and Mouse |
| Q35749630 | Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness. |
| Q42537485 | Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots |
| Q35990303 | Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects |
| Q33569573 | Triumphs of the thyroid despite lesser conversion |
| Q37890563 | Type 2 deiodinase at the crossroads of thyroid hormone action |
| Q37136867 | Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes |
| Q36857216 | Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma. |
| Q34392574 | Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism. |
| Q28587912 | Type 3 deiodinase is critical for the maturation and function of the thyroid axis |
| Q35543635 | Type II iodothyronine deiodinase provides intracellular 3,5,3'-triiodothyronine to normal and regenerating mouse skeletal muscle |
| Q35110847 | Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice |
| Q35110868 | Type-2 iodothyronine 5'deiodinase in skeletal muscle of C57BL/6 mice. I. Identity, subcellular localization, and characterization |
| Q36521134 | Uncoupling Proteins and the Molecular Mechanisms of Thyroid Thermogenesis |
| Q38421463 | Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development |
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