Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone

scientific journal article

Atherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2009.080611
P932PMC publication ID2684166
P698PubMed publication ID19435790
P5875ResearchGate publication ID24421223

P2093author name stringJihong Han
Hideaki Nakaya
Antonio M. Gotto
Andrew C. Nicholson
Barbara D. Summers
David P. Hajjar
P2860cites workEffect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular CausesQ22250883
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PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathwayQ31793810
Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study GroupQ31976463
Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient miceQ32085363
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.Q32085397
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient miceQ33236495
Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice.Q33947837
Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative miceQ34142722
Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux.Q34277079
Anti-inflammatory properties of a platelet-activating factor acetylhydrolaseQ34307399
Effects of pioglitazone and rosiglitazone on blood lipid levels and glycemic control in patients with type 2 diabetes mellitus: a retrospective review of randomly selected medical recordsQ34599640
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trialQ34766176
Low-density lipoprotein receptor--its structure, function, and mutationsQ35806339
Clinical, diagnostic, and therapeutic aspects of familial hypercholesterolemiaQ35806352
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Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targetsQ36721566
The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice.Q37079828
PROactive: time for a critical appraisalQ37122745
HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosisQ37156017
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient miceQ37242527
Reassessing the cardiovascular risks and benefits of thiazolidinedionesQ37264420
Pioglitazone inhibits the expression of inflammatory cytokines from both monocytes and lymphocytes in patients with impaired glucose toleranceQ39935597
Pioglitazone stimulates apolipoprotein A-I production without affecting HDL removal in HepG2 cells: involvement of PPAR-alphaQ40080032
Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell lineQ40219233
Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamideQ40426965
Therapeutic potential of thiazolidinediones in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration.Q40464074
Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophageQ40531038
Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gammaQ40713487
Connective tissue growth factor. Friend or foe?Q41596354
Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cellsQ43513110
High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilizationQ43653251
Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled studyQ43670632
The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitusQ43699554
Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE.Q43843334
Efficacy and safety of pioglitazone in type 2 diabetes: a randomised, placebo-controlled study in patients receiving stable insulin therapyQ44034689
Antiinflammatory and antiarteriosclerotic effects of pioglitazoneQ44201670
Effects of pioglitazone in nondiabetic patients with arterial hypertension: a double-blind, placebo-controlled studyQ44238610
Rosiglitazone (PPARgamma-agonist) attenuates atherogenesis with no effect on hyperglycaemia in a combined diabetes-atherosclerosis mouse modelQ44287903
A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitusQ44480091
Pioglitazone reduces monocyte adhesion to vascular endothelium under flow by modulating RhoA GTPase and focal adhesion kinaseQ44628017
Effect of pioglitazone on carotid intima-media thickness and arterial stiffness in type 2 diabetic nephropathy patientsQ45064729
Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effectsQ46601696
Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazoneQ46620643
Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndromeQ46801114
Peroxisome proliferator-activated receptor-gamma activation with pioglitazone improves endothelium-dependent dilation in nondiabetic patients with major cardiovascular risk factorsQ46930716
Pioglitazone attenuates neointimal thickening via suppression of the early inflammatory response in a porcine coronary after stentingQ46940170
Administration of pioglitazone in low-density lipoprotein receptor-deficient mice inhibits lesion progression and matrix metalloproteinase expression in advanced atherosclerotic plaquesQ50714707
Pioglitazone inhibits in-stent restenosis in atherosclerotic rabbits by targeting transforming growth factor-beta and MCP-1.Q51112774
Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group.Q51552529
Pioglitazone and Rosiglitazone Have Different Effects on Serum Lipoprotein Particle Concentrations and Sizes in Patients With Type 2 Diabetes and DyslipidemiaQ59624472
Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in miceQ64381202
Human plasma platelet-activating factor acetylhydrolase. Oxidatively fragmented phospholipids as substratesQ70169343
Differential inhibitory effects of antidiabetic drugs on arterial smooth muscle cell proliferationQ71789521
Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol effluxQ73596081
Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: the PIOSTAT StudyQ79615264
Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient miceQ80092264
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
atherosclerosisQ12252367
EomesoderminQ21981066
P304page(s)2007–2014
P577publication date2009-06-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleAtherosclerosis in LDLR-knockout mice is inhibited, but not reversed, by the PPARgamma ligand pioglitazone
P478volume174

Reverse relations

cites work (P2860)
Q35395455Acute exercise activates AMPK and eNOS in the mouse aorta
Q36851491Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.
Q39379798Cardiovascular disease and cancer: Evidence for shared disease pathways and pharmacologic prevention.
Q33885504Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease
Q43065142Differential effects of pioglitazone on advanced atherosclerotic lesions
Q27311648Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway
Q34980214Innate immunity and monocyte-macrophage activation in atherosclerosis.
Q38517043Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis
Q30551530Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid.
Q38887788New indole-thiazolidine attenuates atherosclerosis in LDLr(-/-) mice.
Q37790384PPARs as therapeutic targets in cardiovascular disease
Q37627571PPARγ and Its Role in Cardiovascular Diseases.
Q36612212Pioglitazone attenuates valvular calcification induced by hypercholesterolemia
Q42849811SorLA modulates atheroprotective properties of CLA by regulating monocyte migration

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