PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain

scientific journal article

PKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ20082271
P698PubMed publication ID19432558

P2093author name stringJoydip Das
Satyabrata Pany
Ghazi M. Rahman
Simon J. Slater
P2860cites workStructure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogasterQ27641737
The Role of Multiple Hydrogen-Bonding Groups in Specific Alcohol Binding Sites in Proteins: Insights from Structural Studies of LUSHQ27649736
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol esterQ27730271
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Ethanol and protein kinase C.Q33747340
GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilonQ33827844
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.Q33944297
Inhibition of protein kinase C by alcohols and anaestheticsQ34350306
Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptorsQ34364980
Protein kinase C and alcohol addiction.Q34637120
Enhancement of homomeric glycine receptor function by long-chain alcohols and anaestheticsQ35884602
Identification of an alcohol binding site in the first cysteine-rich domain of protein kinase CdeltaQ36458611
Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdalaQ36751542
Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed MutagenesisQ38291447
Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilonQ41696943
Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effectsQ42704387
Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathwaysQ43116175
Reduced ethanol withdrawal severity and altered withdrawal-induced c-fos expression in various brain regions of mice lacking protein kinase C-epsilonQ43581274
The C1 domain of protein kinase C as a lipid bilayer surface sensing moduleQ43713129
The nature of the hydrophobic n-alkanol binding site within the C1 domains of protein kinase CalphaQ44925137
Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase CdeltaQ44964533
Reduced operant ethanol self-administration and in vivo mesolimbic dopamine responses to ethanol in PKCepsilon-deficient mice.Q46034941
Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anestheticQ48126290
Protein kinase C: molecular and cellular targets for the action of ethanolQ48874068
Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinitiesQ49103877
Interaction of alcohols and anesthetics with protein kinase Calpha.Q51546231
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectProtein kinase C, epsilonQ21491045
P304page(s)405–413
P577publication date2009-07-15
P1433published inBiochemical JournalQ864221
P1476titlePKC epsilon has an alcohol-binding site in its second cysteine-rich regulatory domain
P478volume421

Reverse relations

cites work (P2860)
Q396269221H, 13C and 15N NMR assignments of the C1A and C1B subdomains of PKC-delta
Q33724453Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice
Q40696736Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon
Q37775496Alcohol withdrawal and brain injuries: beyond classical mechanisms.
Q37890000Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution
Q33744860Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C.
Q39402279Development of diacyltetrol lipids as activators for the C1 domain of protein kinase C.
Q35812172Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats
Q45903463ERK pathway and sheddases play an essential role in ethanol-induced CX3CL1 release in pancreatic stellate cells.
Q28551627Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome
Q54980051Ethanol-Induced Changes in PKCε: From Cell to Behavior.
Q34424216Ethanol-enhanced GABA release: A focus on G protein-coupled receptors
Q46519736Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders.
Q57801773Identification of alcohol-binding site(s) in proteins using diazirine-based photoaffinity labeling and mass spectrometry
Q27683701Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ)
Q36405131Interactions between ethanol and the endocannabinoid system at GABAergic synapses on basolateral amygdala principal neurons
Q34534789PKC activation by resveratrol derivatives with unsaturated aliphatic chain
Q41091103Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption
Q33767493Protein kinase C deficiency-induced alcohol insensitivity and underlying cellular targets in Drosophila
Q46274906Protein kinase C in fungi - more than just cell wall integrity
Q50888051Resveratrol inhibits phorbol ester-induced membrane translocation of presynaptic Munc13-1.
Q38809648Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands
Q37923872Signaling pathways mediating alcohol effects.
Q36677052Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans
Q27675695Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗
Q41682237The effect of alcohol on recombinant proteins derived from mammalian adenylyl cyclase
Q34378869The neurobiology of alcohol consumption and alcoholism: an integrative history
Q42590696The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila.
Q37890957The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

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