Prion peptide uptake in microglial cells--the effect of naturally occurring autoantibodies against prion protein

scientific article (publication date: 2013)

Prion peptide uptake in microglial cells--the effect of naturally occurring autoantibodies against prion protein is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...867743R
P356DOI10.1371/JOURNAL.PONE.0067743
P932PMC publication ID3695867
P698PubMed publication ID23840767
P5875ResearchGate publication ID248386029

P50authorRichard DodelQ30500712
P2093author name stringInga Zerr
Jan-Philipp Bach
Yvonne Roettger
P2860cites work18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.Q51893579
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Macrophage phagocytosis: use of fluorescence microscopy to distinguish between extracellular and intracellular bacteriaQ68012070
A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in cultureQ71726212
Cellular uptake of the prion protein fragment PrP106-126 in vitroQ73254939
Microglia and the pathogenesis of spongiform encephalopathiesQ73605054
The stimulation of inducible nitric-oxide synthase by the prion protein fragment 106--126 in human microglia is tumor necrosis factor-alpha-dependent and involves p38 mitogen-activated protein kinaseQ73794043
Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microgliaQ74139800
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Signal transduction during Fc receptor-mediated phagocytosisQ28609863
A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophagesQ29616748
Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent mannerQ34161546
Five questions on prion diseasesQ34263032
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Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophagesQ36367162
Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.Q36400800
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A structural overview of the vertebrate prion proteinsQ37080692
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's diseaseQ37118356
Immunotherapy and naturally occurring autoantibodies in neurodegenerative disordersQ37192880
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Role of microglia in neuronal degeneration and regenerationQ37599542
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Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.Q40496060
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Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasin B. Role of subplasmalemmal microfilamentsQ41182472
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseQ41753192
Altered toxicity of the prion protein peptide PrP106-126 carrying the Ala(117)-->Val mutationQ41860073
Molecular determinants of the physicochemical properties of a critical prion protein region comprising residues 106-126.Q41954090
Human anti-prion antibodies block prion peptide fibril formation and neurotoxicityQ41975386
Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis.Q42447316
Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinaseQ42799184
Helix-coil transition of PrP106-126: molecular dynamic studyQ43825559
High-yield isolation of murine microglia by mild trypsinization.Q44645887
Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosisQ46404541
Role of microglia in neuronal cell death in prion diseaseQ47820922
Fibrillar prion peptide (106-126) and scrapie prion protein hamper phagocytosis in microgliaQ47887915
Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokinesQ48234384
Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neurotoxicityQ48272962
Neurotoxicity of a prion protein fragmentQ48304223
Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegenerationQ48570765
Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent processQ48729393
Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burdenQ48766393
Role of microglia and host prion protein in neurotoxicity of a prion protein fragmentQ49050987
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectprion protein familyQ24724413
autoantibodyQ785022
microgliaQ1622829
P304page(s)e67743
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titlePrion peptide uptake in microglial cells--the effect of naturally occurring autoantibodies against prion protein
P478volume8

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cites work (P2860)
Q90050705Encoding the Sequence of Specific Autoantibodies Against beta-Amyloid and alpha-Synuclein in Neurodegenerative Diseases
Q58696119Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein
Q64897506IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease.
Q40065603Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro.
Q34627859Naturally occurring alpha-synuclein autoantibodies in Parkinson's disease: sources of (error) variance in biomarker assays
Q39125010α1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity.

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