Dose and time-dependent selective neurotoxicity induced by mephedrone in mice

scientific article (publication date: 2014)

Dose and time-dependent selective neurotoxicity induced by mephedrone in mice is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...999002M
P356DOI10.1371/JOURNAL.PONE.0099002
P932PMC publication ID4043985
P698PubMed publication ID24892744
P5875ResearchGate publication ID262816364

P50authorRaúl López-ArnauQ40647258
David PubillQ40647297
P2093author name stringSonia Abad
Jorge Camarasa
José Martínez-Clemente
Elena Escubedo
P2860cites workThe designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissueQ24615008
Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake ratsQ24617723
Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatumQ24621938
4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuseQ24634712
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Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methyloneQ28264655
Pharmacological characterization of designer cathinones in vitroQ28273207
Role of the dopaminergic system in the acquisition, expression and reinstatement of MDMA-induced conditioned place preference in adolescent miceQ28482310
Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley ratsQ28483306
Mephedrone in adolescent rats: residual memory impairment and acute but not lasting 5-HT depletionQ28483841
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Dose translation from animal to human studies revisitedQ29618049
Mephedrone: use, subjective effects and health risks.Q30402845
Hyperthermia and multiorgan failure after abuse of "bath salts" containing 3,4-methylenedioxypyrovaleroneQ30455174
Substituted cathinone products: a new trend in "bath salts" and other designer stimulant drug use.Q30456717
In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activityQ30535782
Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.Q54618281
Tweaking, bombing, dabbing and stockpiling: the emergence of mephedrone and the perversity of prohibitionQ56446476
Mephedrone, a new designer drug of abuse, produces acute hemodynamic effects in the ratQ57098503
Effects of dopamine, NMDA, opiate, and serotonin-related agents on acute methamphetamine-induced self-injurious behavior in miceQ74014957
Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase IIQ80863697
Human pharmacology of MDMA: pharmacokinetics, metabolism, and dispositionQ33979466
A comparison of InVivoStat with other statistical software packages for analysis of data generated from animal experimentsQ34071111
Clinical pattern of toxicity associated with the novel synthetic cathinone mephedrone.Q34122952
Instability of the ecstasy market and a new kid on the block: mephedroneQ34136889
Mephedrone (4-methylmethcathinone; 'meow meow'): chemical, pharmacological and clinical issues.Q34149434
Drugs for youth via Internet and the example of mephedroneQ34156700
Experiences with mephedrone pre- and post-legislative controls: perceptions of safety and sources of supplyQ34159476
Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of "bath salts," produce opposite effects at the human dopamine transporterQ34325588
Molecular profile of reactive astrocytes--implications for their role in neurologic diseaseQ34366853
Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)Q34625141
Dopamine in drug abuse and addiction: results from imaging studies and treatment implicationsQ35751195
Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaquesQ36419322
Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in ratsQ36511778
Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' productsQ36610017
The Nature of 3, 4-Methylenedioxymethamphetamine (MDMA)-Induced Serotonergic Dysfunction: Evidence for and Against the Neurodegeneration HypothesisQ37925507
"Bath salt" ingestion leading to severe intoxication delirium: two cases and a brief review of the emergence of mephedrone use.Q37973442
MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperatureQ38758177
Behavioural despair in rats: A new model sensitive to antidepressant treatmentsQ40134604
Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes.Q40561021
Methcathinone intoxication in the rat: abrogation by dextrorphanQ40655146
A rapid method to separate endosomes from lysosomal contents using differential centrifugation and hypotonic lysis of lysosomesQ40929301
The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neuronsQ42715803
Mephedrone (4-methylmethcathinone)-related deathsQ42744621
Mephedrone: still available and twice the priceQ42833281
Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatumQ43575212
Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entryQ43945482
Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell killQ44302226
Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics.Q44403001
Risperidone reduction of amphetamine-induced self-injurious behavior in miceQ44783784
Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neuronesQ45053012
Long-term cognitive and neurochemical effects of "bath salt" designer drugs methylone and mephedrone.Q46354611
Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptorsQ46632223
Repeated administration of MDMA causes transient down-regulation of serotonin 5-HT2 receptorsQ46944880
MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neuronsQ48121118
Developmental dissociation of methamphetamine-induced depletion of dopaminergic terminals and astrocyte reaction in rat striatumQ48302935
Interaction of mephedrone with dopamine and serotonin targets in ratsQ48958751
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectneurotoxicityQ3338704
toxic encephalopathyQ7830379
P304page(s)e99002
P577publication date2014-01-01
P1433published inPLOS OneQ564954
P1476titleDose and time-dependent selective neurotoxicity induced by mephedrone in mice
P478volume9

Reverse relations

cites work (P2860)
Q344599843,4-Methylenedioxypyrovalerone prevents while methylone enhances methamphetamine-induced damage to dopamine nerve endings: β-ketoamphetamine modulation of neurotoxicity by the dopamine transporter
Q41908015Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition.
Q50278637Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine
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Q53687526DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants.
Q53766695Dissecting the Influence of Two Structural Substituents on the Differential Neurotoxic Effects of Acute Methamphetamine and Mephedrone Treatment on Dopamine Nerve Endings with the Use of 4-Methylmethamphetamine and Methcathinone.
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Q36674322Effect of Some Psychoactive Drugs Used as 'Legal Highs' on Brain Neurotransmitters
Q50452744Exposure of adolescent mice to 3,4-methylenedioxypyrovalerone increases the psychostimulant, rewarding and reinforcing effects of cocaine in adulthood
Q48505973In vivo [¹⁸F] FDG PET imaging reveals that p-chloroamphetamine neurotoxicity is associated with long-term cortical and hippocampal hypometabolism
Q38828261Mitochondrial respiratory dysfunction due to the conversion of substituted cathinones to methylbenzamides in SH-SY5Y cells
Q34546425Neurotoxicity Induced by Mephedrone: An up-to-date Review
Q38983638Neurotoxicology of Synthetic Cathinone Analogs
Q95854597Psychoactive Bath Salts and Neurotoxicity Risk
Q40918288Staphylococcus aureus bacteraemia associated with injected new psychoactive substances
Q58602767Synthetic cathinone adulteration of illegal drugs
Q89728368Synthetic psychoactive cathinones: hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine
Q88361885The Designer Drug 3-Fluoromethcathinone Induces Oxidative Stress and Activates Autophagy in HT22 Neuronal Cells
Q64989939The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats.

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