Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain

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Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1017690L
P356DOI10.1371/JOURNAL.PONE.0117690
P932PMC publication ID4335000
P698PubMed publication ID25695632
P5875ResearchGate publication ID272517182

P2093author name stringLili Zhang
Xiaofeng Cai
Jing He
Qiang He
Luyao Huang
Aiying Li
Wenwen Guo
Jin Lü
P2860cites workGenomic sequence-based discovery of novel angucyclinone antibiotics from marine Streptomyces sp. W007.Q53109394
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Isolation of cytotoxic substance, kalafungin from an alkalophilic actinomycete, Nocardiopsis dassonvillei subsp. prasinaQ68663524
Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyces tanashiensisQ71920965
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Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin A methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producerQ33433766
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Pyranonaphthoquinone lactones: a new class of AKT selective kinase inhibitors alkylate a regulatory loop cysteineQ39869048
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteinesQ40055011
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clustersQ42603435
Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related Streptomyces antibiotics.Q42711829
Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms.Q42975780
Biosynthesis of actinorhodin and related antibiotics: discovery of alternative routes for quinone formation encoded in the act gene clusterQ46107677
A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolorQ46424889
Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesisQ46709251
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)e0117690
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleAccumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain
P478volume10