OM2, a Novel Oligomannuronate-Chromium(III) Complex, Promotes Mitochondrial Biogenesis and Lipid Metabolism in 3T3-L1 Adipocytes via the AMPK-PGC1α Pathway

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OM2, a Novel Oligomannuronate-Chromium(III) Complex, Promotes Mitochondrial Biogenesis and Lipid Metabolism in 3T3-L1 Adipocytes via the AMPK-PGC1α Pathway is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1031930H
P356DOI10.1371/JOURNAL.PONE.0131930
P8608Fatcat IDrelease_xyl3ugen7fel3j2kgj2wflaxpq
P3181OpenCitations bibliographic resource ID2477506
P932PMC publication ID4503612
P698PubMed publication ID26176781
P5875ResearchGate publication ID280303371

P2093author name stringXin Liu
Cui Hao
Guangli Yu
Xiaoliang Zhao
Lijuan Zhang
Jiankang Liu
Jiejie Hao
Haihua Li
Xiaolin Zhou
Yuanyuan An
Guangsheng Li
Yunlou Dun
P2860cites workInsulin sensitizing effects of oligomannuronate-chromium (III) complexes in C2C12 skeletal muscle cellsQ21135221
Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayQ24607012
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell functionQ26865723
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Q28131760
AMPK: a nutrient and energy sensor that maintains energy homeostasisQ29615410
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alphaQ29620443
Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissuesQ30529628
The marine-derived oligosaccharide sulfate (MdOS), a novel multiple tyrosine kinase inhibitor, combats tumor angiogenesis both in vitro and in vivoQ33385649
Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individualsQ33940807
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Rationale for the existence of additional adipostatic hormones.Q34353837
Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone.Q53572340
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipaseQ34369246
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.Q35630386
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Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndromeQ36462351
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AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevanceQ36711158
AMP-activated protein kinase and its downstream transcriptional pathwaysQ36756228
Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in ratsQ37135952
Impaired mitochondrial function and insulin resistance of skeletal muscle in mitochondrial diabetes.Q37139489
Overview of adipose tissue and its role in obesity and metabolic disordersQ37179054
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureQ37412140
Mitochondria as potential targets in antidiabetic therapyQ37864219
Mitochondria are impaired in the adipocytes of type 2 diabetic miceQ38315463
Efficacy of adding sodium alginate to omeprazole in patients with nonerosive reflux disease: a randomized clinical trialQ39256826
α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinaseQ39372653
Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions.Q39380440
Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGLQ41780034
Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma.Q42003574
Chromium(III) propionate complex supplementation improves carbohydrate metabolism in insulin-resistance rat modelQ42474377
Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress.Q42504251
The effects of chromium complex and level on glucose metabolism and memory acquisition in rats fed high-fat diet.Q42789268
Long-term effects of chitosan oligosaccharide in streptozotocin-induced diabetic ratsQ42794234
Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes.Q42796321
Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat.Q42809543
The role of an alginate suspension on pepsin and bile acids - key aggressors in the gastric refluxate. Does this have implications for the treatment of gastro-oesophageal reflux disease?Q43287021
Comparison of adipose tissue changes following administration of rosiglitazone in the dog and rat.Q43644865
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacityQ44527020
Alginate oligosaccharide protects against endoplasmic reticulum- and mitochondrial-mediated apoptotic cell death and oxidative stressQ44909948
Production of oligosaccharide from alginate using Pseudoalteromonas agarovoransQ46153093
Alginate-deriving oligosaccharide production by alginase from newly isolated Flavobacterium sp. LXA and its potential application in protection against pathogensQ46215654
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.Q46752037
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.Q47753079
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
P304page(s)e0131930
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleOM2, a Novel Oligomannuronate-Chromium(III) Complex, Promotes Mitochondrial Biogenesis and Lipid Metabolism in 3T3-L1 Adipocytes via the AMPK-PGC1α Pathway
P478volume10

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cites work (P2860)
Q51280109AMP-activated protein kinase-mediated expression of heat shock protein beta 1 enhanced insulin sensitivity in the skeletal muscle.
Q36791238Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway