cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

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cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1004815
P932PMC publication ID4423841
P698PubMed publication ID25951195
P5875ResearchGate publication ID276433454

P50authorOdile Mercereau-PuijalonQ28322958
Catherine LavazecQ28778523
Kenneth D VernickQ56777754
David A. BakerQ37840581
Yolanda CorbettQ41938103
Donatella TaramelliQ46250423
P2093author name stringBernina Naissant
Gordon Langsley
Ghania Ramdani
Eloise Thompson
Audrey Lorthiois
Florian Dupuy
Yoann Duffier
Florence Breil
Ross Cummings
P2860cites workRed cell membrane: past, present, and futureQ22299207
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Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasiteQ27314651
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Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein exportQ27334032
Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytesQ27973621
The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytesQ27974567
Human malaria parasites in continuous cultureQ28131626
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Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinaseQ28472951
Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparumQ30042317
Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductanceQ30042466
MESA is a Plasmodium falciparum phosphoprotein associated with the erythrocyte membrane skeletonQ30049265
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.Q33326989
The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogonyQ33585913
The distribution of Plasmodium falciparum in the peripheral blood and bone marrow of Gambian childrenQ47991664
Microsphiltration: a microsphere matrix to explore erythrocyte deformabilityQ48020430
The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signalingQ48021425
Modulation of red cell band 4.1 function by cAMP-dependent kinase and protein kinase C phosphorylationQ48111738
TbPDE1, a novel class I phosphodiesterase of Trypanosoma bruceiQ61573924
Patterns of antigen expression in asexual blood stages and gametocytes of Plasmodium falciparumQ68131763
Comparison of adenylate cyclase and cAMP-dependent protein kinase in gametocytogenic and nongametocytogenic clones of Plasmodium falciparumQ70169976
Gametocytogenesis of Plasmodium falciparum in vitro: an electron microscopic studyQ70221465
Photoaffinity labelling of cyclic GMP-inhibited phosphodiesterase (PDE III) in human and rat platelets and rat tissues: effects of phosphodiesterase inhibitorsQ72716038
Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrowQ33794320
Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparumQ34086895
Differential adhesive properties of sequestered asexual and sexual stages of Plasmodium falciparum on human endothelial cells are tissue independentQ34171103
Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and eliminationQ34177472
Plasmodium falciparum transmission stages accumulate in the human bone marrowQ34245311
Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.Q34401845
The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro.Q34707643
Phosphodiesterase inhibitors as a new generation of antiprotozoan drugs: exploiting the benefit of enzymes that are highly conserved between host and parasiteQ35189546
Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical propertiesQ35669258
Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum.Q36035540
A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stagesQ36057631
Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesisQ37040775
Current knowledge about the functional roles of phosphorylative changes of membrane proteins in normal and diseased red cellsQ37598401
Cyclic nucleotide signalling in malaria parasitesQ37822908
Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?Q38039663
PDE5 inhibitors: considerations for preference and long-term adherenceQ38122721
Improved synchronous production of Plasmodium falciparum gametocytes in vitroQ39005607
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparumQ39278961
A Plasmodium falciparum screening assay for anti-gametocyte drugs based on parasite lactate dehydrogenase detectionQ41925849
The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?Q42424857
The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategiesQ42562371
Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiationQ42824519
Early gametocytes of the malaria parasite Plasmodium falciparum specifically remodel the adhesive properties of infected erythrocyte surfaceQ43713662
The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytesQ43739315
Organization and function of an actin cytoskeleton in Plasmodium falciparum gametocytesQ44145739
Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3',5' monophosphate accumulation and adenosine 3'5' triphosphate release from human erythrocytesQ44499510
Erythrocyte G Protein-Coupled Receptor Signaling in Malarial InfectionQ44590989
Expression switching in the stevor and Pfmc-2TM superfamilies in Plasmodium falciparumQ45266426
Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein.Q46008398
Calyculin A-sensitive protein phosphatases are involved in maintenance of progressive movement in mouse spermatozoa in vitro by suppression of autophosphorylation of protein kinase A.Q46085002
Susceptibility of Plasmodium falciparum cyclic AMP-dependent protein kinase and its mammalian homologue to the inhibitorsQ46576678
Modulation of the growth of Plasmodium falciparum in vitro by protein serine/threonine phosphatase inhibitorsQ47939519
Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparumQ47956702
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcAMP-dependent protein kinase catalytic subunitQ56569920
malaria transmissionQ56928847
P304page(s)e1004815
P577publication date2015-05-01
P1433published inPLOS PathogensQ283209
P1476titlecAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission
P478volume11

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cites work (P2860)
Q56363345Commit, hide and escape: the story of Plasmodium gametocytes
Q47097185Cyclic nucleotide signalling in malaria parasites
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Q60922149Druggable Targets in Cyclic Nucleotide Signaling Pathways in Apicomplexan Parasites and Kinetoplastids against Disabling Protozoan Diseases in Humans
Q91583957Erythrocyte Membrane Makeover by Plasmodium falciparum Gametocytes
Q56379600High-throughput microsphiltration to assess red blood cell deformability and screen for malaria transmission-blocking drugs
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Q36866069Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages
Q92904193Revisiting gametocyte biology in malaria parasites
Q35746071Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria
Q55411797Squeezing for Life - Properties of Red Blood Cell Deformability.
Q64101328Studying the rigidity of red blood cells induced by Plasmodium falciparum infection
Q47932731Viagra® makes Plasmodium stiff: a novel way to block malaria transmission?

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