Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF

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Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1037410E
P356DOI10.1371/JOURNAL.PONE.0137410
P3181OpenCitations bibliographic resource ID2628655
P932PMC publication ID4564171
P698PubMed publication ID26352269
P5875ResearchGate publication ID281634582

P2093author name stringGeorge A Garcia
Anthony A Emanuele
P2860cites workExpression of four virulence antigens of Shigella flexneri is positively regulated at the transcriptional level by the 30 kiloDalton virF protein.Q54742538
Differential regulation of the plasmid-encoded genes in the Shigella flexneri virulence regulonQ73829435
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinityQ75291185
Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factorsQ80980188
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonizationQ28276944
Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaBQ28289989
AraC protein: a love-hate relationship.Q30332519
Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneriQ30580404
High-throughput screening of the virulence regulator VirF: a novel antibacterial target for shigellosisQ33541815
Small Molecule Inhibitors of LcrF, a Yersinia pseudotuberculosis Transcription Factor, Attenuate Virulence and Limit Infection in a Murine Pneumonia ModelQ33686625
Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actinQ33859430
The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranesQ33878820
Characterization of a novel DNA minor-groove complexQ34184633
The AraC transcriptional activatorsQ34204972
Identification of a small-molecule inhibitor of bacterial AraC family activatorsQ34567886
Involvement of cpxA, a sensor of a two-component regulatory system, in the pH-dependent regulation of expression of Shigella sonnei virF geneQ35593700
Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.Q36422508
Mutagenesis of the Shigella flexneri autotransporter IcsA reveals novel functional regions involved in IcsA biogenesis and recruitment of host neural Wiscott-Aldrich syndrome proteinQ36747291
Loss of pigmentation in Shigella flexneri 2a is correlated with loss of virulence and virulence-associated plasmidQ37080399
Small-molecule inhibitor of the Shigella flexneri master virulence regulator VirF.Q37264871
N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agentsQ37423363
A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinityQ38291570
Transcriptional control of the invasion regulatory gene virB of Shigella flexneri: activation by virF and repression by H-NSQ38315694
LUEGO: a cost and time saving gel shift procedureQ38331201
A multifactor regulatory circuit involving H-NS, VirF and an antisense RNA modulates transcription of the virulence gene icsA of Shigella flexneri.Q38333799
IcsA is a Shigella flexneri adhesin regulated by the type III secretion system and required for pathogenesisQ39005507
In vivo DNA-binding and oligomerization properties of the Shigella flexneri AraC-like transcriptional regulator VirF as identified by random and site-specific mutagenesisQ39694760
Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound libraryQ39741643
Thermoregulation of virB transcription in Shigella flexneri by sensing of changes in local DNA superhelicityQ39835748
H-NS regulation of virulence gene expression in enteroinvasive Escherichia coli harboring the virulence plasmid integrated into the host chromosomeQ39837977
A role for H-NS in the thermo-osmotic regulation of virulence gene expression in Shigella flexneriQ39932607
Virulence-associated genetic regions comprising 31 kilobases of the 230-kilobase plasmid in Shigella flexneri 2a.Q39953337
Spontaneous insertion of an IS1-like element into the virF gene is responsible for avirulence in opaque colonial variants of Shigella flexneri 2a.Q40148576
Temperature-regulated expression of invasion genes inShigella flexneriis controlled through the transcriptional activation of thevirBgene on the large plasmidQ41689426
IpaD localizes to the tip of the type III secretion system needle of Shigella flexneriQ41856079
Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS.Q42662171
A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in S. flexneri 2a.Q44058237
OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosisQ44091047
A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneriQ48298555
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectvirulenceQ1460232
Shigella flexneriQ1644417
P304page(s)e0137410
P577publication date2015-01-01
P1433published inPLOS OneQ564954
P1476titleMechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF
P478volume10

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cites work (P2860)
Q47132385Low distribution of genes encoding virulence factors in Shigella flexneri serotypes 1b clinical isolates from eastern Chinese populations
Q89353430Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening
Q41975124One Gene and Two Proteins: a Leaderless mRNA Supports the Translation of a Shorter Form of the Shigella VirF Regulator.
Q28072947The Multifaceted Activity of the VirF Regulatory Protein in the Shigella Lifestyle
Q41950223VirF Relieves the Transcriptional Attenuation of the Virulence Gene icsA of Shigella flexneri Affecting the icsA mRNA-RnaG Complex Formation

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