Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction

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Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction is …
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P819ADS bibcode2016PLoSO..1151702J
P356DOI10.1371/JOURNAL.PONE.0151702
P932PMC publication ID4795798
P698PubMed publication ID26986758
P5875ResearchGate publication ID298797385

P50authorLetitia JonesQ59360206
Joseph W JacksonQ61163039
Sanjay B MaggirwarQ98512616
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Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by lipopolysaccharideQ36804543
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Platelet factor 4 (CXCL4) facilitates human macrophage infection with HIV-1 and potentiates virus replicationQ39440973
HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier levelQ39515527
Simian immunodeficiency virus encephalitis in rhesus macaques is associated with rapid disease progression.Q39588377
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CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.Q40658295
Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis.Q41494592
Blood-brain barrier disruption in simian immunodeficiency virus encephalitisQ42495207
Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-kappaB dependent pathway in human astrocytesQ43131684
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HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cellsQ45140660
Simian immunodeficiency virus disrupts extended lengths of the blood--brain barrier.Q45424296
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
brainQ1073
neuronitisQ17157137
blood–brain barrierQ221694
P304page(s)e0151702
P577publication date2016-01-01
P1433published inPLOS OneQ564954
P1476titleModeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction
P478volume11

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cites work (P2860)
Q55255033EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment.
Q38701621Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection.
Q38768300HIV infection model of chronic obstructive pulmonary disease in mice
Q92537389High Neutrophil-to-Platelet Ratio Is Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke
Q48353365In vitro analysis of platelet function in acute aneurysmal subarachnoid haemorrhage
Q61446591Interaction of Treponema pallidum, the syphilis spirochete, with human platelets
Q64228002Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice
Q40147390Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling
Q52623432Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice.
Q55004062Platelets in Immune Response to Virus and Immunopathology of Viral Infections.

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