Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides

scientific journal article

Regulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2006.115246
P8608Fatcat IDrelease_xr5dt3hhj5egvj5k3tht6fw56y
P3181OpenCitations bibliographic resource ID1391514
P932PMC publication ID1995631
P698PubMed publication ID16857707
P5875ResearchGate publication ID6927698

P2093author name stringYoshihiro Kubo
Yuichiro Fujiwara
P2860cites workThe phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1Q24300087
Alterations in conserved Kir channel-PIP2 interactions underlie channelopathiesQ24300436
ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4Q24311307
The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channelQ27627230
Allosteric control of gating and kinetics at P2X(4) receptor channelsQ28142880
Synthesis and function of 3-phosphorylated inositol lipidsQ28200755
Molecular physiology of P2X receptorsQ28203477
Identification of a trafficking motif involved in the stabilization and polarization of P2X receptorsQ28260238
Receptors for purines and pyrimidinesQ28283941
Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channelsQ28288639
The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)Q28568856
A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATPQ28573068
A phospholipid sensor controls mechanogating of the K+ channel TREK-1.Q33432568
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarityQ33660588
Dynamic selectivity filters in ion channelsQ33731015
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptorQ34292603
Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neuronsQ34296118
The complex and intriguing lives of PIP2 with ion channels and transportersQ34457658
Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifsQ34459677
Membrane phospholipid control of nucleotide sensitivity of KATP channelsQ34478704
Phosphoinositide signaling; from affinity probes to pharmaceutical targetsQ35781178
Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanismQ36372211
Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.Q36436571
Control of P2X(2) channel permeability by the cytosolic domainQ36447167
pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndromeQ36787083
Domains of P2X receptors involved in desensitizationQ37098145
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivityQ37357736
N-methyl-D-glucamine and propidium dyes utilize different permeation pathways at rat P2X(7) receptorsQ40386629
Modulation of the olfactory CNG channel by Ptdlns(3,4,5)P3.Q40474031
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamicsQ40489469
Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions.Q40490745
Inactivation of P2X2 purinoceptors by divalent cationsQ40905705
Contributions of the C-terminal domain to the control of P2X receptor desensitizationQ40910250
Pore dilation of neuronal P2X receptor channelsQ40960421
Identification of a site that modifies desensitization of P2X2 receptors.Q40991089
Two mechanisms for inward rectification of current flow through the purinoceptor P2X2 class of ATP-gated channelsQ41055990
Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds.Q41646184
The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphateQ41750994
PIP2 and PIP as determinants for ATP inhibition of KATP channelsQ42538515
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by GbetagammaQ42544747
Inhibition of TASK-1 potassium channel by phospholipase C.Q43666382
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesisQ44092262
Dual regulation of voltage-gated calcium channels by PtdIns(4,5)P2.Q44200822
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currentsQ44386912
Functional conversion between A-type and delayed rectifier K+ channels by membrane lipidsQ44805676
Density-dependent changes of the pore properties of the P2X2 receptor channelQ44859237
A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brainQ48066948
Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitizationQ48564821
Identification of a functional phosphatidylinositol 3,4,5-trisphosphate binding site in the epithelial Na+ channel.Q51813999
PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome.Q52104361
Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors.Q52588091
P433issuePt 1
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
P304page(s)135–149
P577publication date2006-10-01
P1433published inJournal of PhysiologyQ7743612
P1476titleRegulation of the desensitization and ion selectivity of ATP-gated P2X2 channels by phosphoinositides
P478volume576

Reverse relations

cites work (P2860)
Q28481252A dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel family
Q35122793Activation and regulation of purinergic P2X receptor channels
Q36825825Allosteric modulation of ATP-gated P2X receptor channels
Q52366546Allostery revealed within lipid binding events to membrane proteins.
Q37732004Channelopathies linked to plasma membrane phosphoinositides.
Q27307804Characterization of ATPase Activity of P2RX2 Cation Channel
Q37256428Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system
Q39866309Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore.
Q48153727Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.
Q41025603Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate
Q37596780Dynamic aspects of functional regulation of the ATP receptor channel P2X2.
Q43250084Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.
Q34330733Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents
Q37084254Interaction of P2 purinergic receptors with cellular macromolecules.
Q38273638Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis
Q39668991Lipid raft association and cholesterol sensitivity of P2X1-4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors
Q42095503Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes
Q33502752Modeling and analysis of the molecular basis of pain in sensory neurons
Q24617046Molecular and functional properties of P2X receptors--recent progress and persisting challenges
Q33568005Molecular characterization and expression analysis of ATP-gated P2X7 receptor involved in Japanese flounder (Paralichthys olivaceus) innate immune response
Q88504679Novel channel-mediated choline transport in cholinergic neurons of the mouse retina
Q48608499On-site energy supply at synapses through monocarboxylate transporters maintains excitatory synaptic transmission.
Q55262685Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel.
Q61800294Organization of ATP-gated P2X1 receptor intracellular termini in apo and desensitized states
Q36945667Phosphoinositide signaling in somatosensory neurons
Q37066703Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions
Q35192402Phosphoinositides regulate ion channels.
Q27012953Phosphoinositides: tiny lipids with giant impact on cell regulation
Q38170103Post-translational regulation of P2X receptor channels: modulation by phospholipids
Q30387364Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells
Q36811213Regulation of ATP-gated P2X receptors by phosphoinositides
Q38111276Regulation of ion channels by membrane lipids
Q36296038Responses of rat P2X2 receptors to ultrashort pulses of ATP provide insights into ATP binding and channel gating
Q64063131Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel
Q24336573Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
Q37325413Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors.
Q42132759The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons
Q27678972The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H(+) channel Hv1
Q40040884The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels
Q41893172Use of chimeras, point mutants, and molecular modeling to map the antagonist-binding site of 4,4',4″,4‴-(carbonylbis-(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid (NF449) at P2X1 receptors for ATP.
Q37023269Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel.

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