A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration

scientific journal article

A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.109.163279
P932PMC publication ID3202465
P698PubMed publication ID20118207
P5875ResearchGate publication ID41191263

P2093author name stringWilliam A. Banks
Anne-Catherine Lecourt
Jean-Christophe Peter
Géraldine Zipfel
Karl G. Hofbauer
Marjorie Weckering
Michael L. Niehoff
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Hybridoma fusion cell lines contain an aberrant kappa transcriptQ45216793
Effects on heart rate of an anti-M2 acetylcholine receptor immune response in miceQ46516595
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Role of central melanocortins in endotoxin-induced anorexia.Q48268128
Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous systemQ48307913
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Molecular cloning, expression, and gene localization of a fourth melanocortin receptorQ28118785
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor geneQ28185036
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake dataQ28274520
Central melanocortin receptors regulate insulin actionQ28360753
New drugs for the treatment of rheumatoid arthritisQ33837810
Peripheral administration of a melanocortin 4-receptor inverse agonist prevents loss of lean body mass in tumor-bearing miceQ33993122
Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteinsQ34035426
Central melanocortins and the regulation of weight during acute and chronic diseaseQ34174127
The use of melanocortin antagonists in cachexia of chronic diseaseQ34561151
Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic diseaseQ34570343
Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanismQ34647997
Variation in gene expression patterns in follicular lymphoma and the response to rituximabQ34762576
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsinQ35081967
A metabolic defect promotes obesity in mice lacking melanocortin-4 receptorsQ35431515
Hypothalamic melanocortin neurons integrate signals of energy stateQ35586599
The central melanocortin system and the integration of short- and long-term regulators of energy homeostasisQ35641894
The MC4 receptor and control of appetiteQ36054459
Lymphocyte membrane IgG and secreted IgG are structurally and allotypically distinctQ36343610
Monoclonal IgM antibody exhibiting high-affinity binding and cryoglobulin propertiesQ37346284
Leptin enters the brain by a saturable system independent of insulinQ38363314
Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairmentQ40117145
Antibodies against the melanocortin-4 receptor act as inverse agonists in vitro and in vivoQ40166731
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humansQ40177137
Characterization of a novel human anti-HIV-1 gp41 IgM monoclonal antibody designated clone 37.Q40463218
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
pharmacologyQ128406
monoclonal antibodyQ422248
P304page(s)478–490
P577publication date2010-05-01
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleA pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration
P478volume333

Reverse relations

cites work (P2860)
Q34788441Agnostic about in vivo inverse agonism of agouti-related peptide
Q38705664From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery
Q37983474MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?
Q35679471Neuroanatomical evidence of the melanocortin-4 receptor expression in the mesencephalic periaqueductal gray innervating renal tissues
Q34712204Neuropeptides in the pathophysiology and treatment of cachexia
Q48191897Novel anti IGFBP2 single chain variable fragment inhibits glioma cell migration and invasion
Q41845215Protective effects of an anti-melanocortin-4 receptor scFv derivative in lipopolysaccharide-induced cachexia in rats
Q48290634Recombinant single-chain antibody with the Trojan peptide penetratin positioned in the linker region enables cargo transfer across the blood-brain barrier
Q28728941Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits
Q35223982The orally active melanocortin-4 receptor antagonist BL-6020/979: a promising candidate for the treatment of cancer cachexia

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