Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling

scientific journal article

Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1053/J.GASTRO.2006.07.003
P8608Fatcat IDrelease_76f2cmrcc5fzrfj5k4hb4e5s5e
P3181OpenCitations bibliographic resource ID5112053
P932PMC publication ID1866168
P698PubMed publication ID16952559
P5875ResearchGate publication ID6836654

P2093author name stringNicholas F. LaRusso
Patrick L. Splinter
Anatoliy I. Masyuk
Angela J. Stroope
Bing Q. Huang
Tatyana V. Masyuk
P2860cites workUltrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situQ48035937
Defects in cholangiocyte fibrocystin expression and ciliary structure in the PCK rat.Q52552433
Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.Q53855784
News focus: Betting on cilia.Q54304196
Localization of calcium channels in Paramecium caudatumQ67698596
Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liverQ71036017
Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ionsQ73288688
Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective forceQ74582573
Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasmQ24305942
Polycystic disease of the liverQ28283470
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cellsQ28505110
Polarized expression and function of P2Y ATP receptors in rat bile duct epitheliaQ28565286
Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney diseaseQ28585961
The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal ciliaQ29615732
Two populations of node monocilia initiate left-right asymmetry in the mouseQ29617071
Regulation of cholangiocyte bile secretionQ33698297
Functional properties of Ca2+-inhibitable type 5 and type 6 adenylyl cyclases and role of Ca2+ increase in the inhibition of intracellular cAMP contentQ33756973
Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoformsQ34330546
Regulation of cholangiocyte bicarbonate secretionQ34344156
An incredible decade for the primary cilium: a look at a once-forgotten organelleQ34465976
Flow-mediated endothelial mechanotransductionQ34648558
Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney diseaseQ35103361
Molecular and cellular requirements for the regulation of adenylate cyclases by calciumQ35541325
Left-Right Asymmetry: Nodal Cilia Make and Catch a WaveQ35560820
Polycystins and mechanosensation in renal and nodal ciliaQ35845609
A physiological view of the primary ciliumQ36041059
Cilium-generated signaling and cilia-related disordersQ36050308
Primary cilia of human endothelial cells disassemble under laminar shear stressQ36322273
Polycystic liver and kidney diseasesQ36336546
Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytesQ36891862
Mechanoregulation of intracellular Ca2+ concentration is attenuated in collecting duct of monocilium-impaired orpk miceQ39721139
Glucose reabsorption from bile. Evidence for a biliohepatic circulationQ40368003
Removal of the MDCK cell primary cilium abolishes flow sensingQ40676837
Bending the MDCK cell primary cilium increases intracellular calciumQ40771361
Bile duct epithelium: frontiers in transport physiologyQ41083798
Primary cilia in normal and pathological tissuesQ41160293
Intrahepatic bile ducts transport water in response to absorbed glucoseQ44101872
Regulation of cholangiocyte secretionQ44165090
Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAsQ44240350
Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting ductQ44499345
Sugar absorption by the biliary ductular epithelium of the rat: Evidence for two transport systemsQ46032077
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectfluid flowQ12142910
P304page(s)911–920
P577publication date2006-09-01
P1433published inGastroenterologyQ4039279
P1476titleCholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2+ and cAMP signaling
P478volume131

Reverse relations

cites work (P2860)
Q92983212A Bile Duct-on-a-Chip With Organ-Level Functions
Q22001112A method for measuring electrical signals in a primary cilium
Q36739748A novel biosensor to study cAMP dynamics in cilia and flagella
Q38258036Adenylate cyclase regulates elongation of mammalian primary cilia
Q54846617Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Q38187513Adenylyl cyclases in the digestive system.
Q40844345Altered store operated calcium entry increases cyclic 3',5'-adenosine monophosphate production and extracellular signal-regulated kinases 1 and 2 phosphorylation in polycystin-2-defective cholangiocytes
Q38255292An approach to cystic kidney diseases: the clinician's view
Q38962914An experimental and computational analysis of primary cilia deflection under fluid flow.
Q36817088An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron
Q37216909Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells
Q24656249Autosomal dominant polycystic kidney disease: the last 3 years
Q34212071Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia.
Q57115313Calcium Signaling in Liver Injury and Regeneration
Q38876014Calcium channels in primary cilia
Q38194699Calcium signaling and the secretory activity of bile duct epithelia
Q41960056Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: are they independent or coordinated molecular events?
Q38110517Calcium signaling in the liver
Q37798910Calcium-mediated mechanisms of cystic expansion
Q36497518Centrosome positioning in vertebrate development
Q37317821Cholangiociliopathies: genetics, molecular mechanisms and potential therapies
Q30513913Cholangiocyte cilia are abnormal in syndromic and non-syndromic biliary atresia
Q36277264Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion.
Q64913364Cholangiocyte pathobiology.
Q28577465Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors
Q36953076Cholangiocyte primary cilia in liver health and disease
Q36923647Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling
Q30575795Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli
Q38264623Computational models of the primary cilium and endothelial mechanotransmission.
Q35655072Congenital hepatic fibrosis in autosomal recessive polycystic kidney disease
Q28566509Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation
Q34305511Direct demonstration of tubular fluid flow sensing by macula densa cells
Q36238180Dynamics of the primary cilium in shear flow
Q34399971ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice
Q38064200Emerging role of primary cilia as mechanosensors in osteocytes
Q33866800Estrogens and the pathophysiology of the biliary tree
Q39990068Flow modulates centriole movements in tubular epithelial cells
Q54400236Fluid Shear Stress Induces Renal Epithelial Gene Expression through Polycystin-2-Dependent Trafficking of Extracellular Regulated Kinase
Q39995163Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl- transport in biliary epithelial cells through a PKCzeta-dependent pathway
Q46565214Fluid flow sensing and triggered nucleotide release in epithelia.
Q35906117Force-response considerations in ciliary mechanosensation
Q30450537From central to rudimentary to primary: the history of an underappreciated organelle whose time has come. The primary cilium
Q34779022Functional anatomy of normal bile ducts
Q50457521G-Protein-Coupled Receptor Signaling in Cilia
Q38978453Genetic Mechanisms of ADPKD.
Q34035361HDAC6 inhibition restores ciliary expression and decreases tumor growth
Q56931604HNF1B deficiency causes ciliary defects in human cholangiocytes
Q28569447Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease
Q34431996Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective
Q35919332Identification of drugs that restore primary cilium expression in cancer cells
Q41579424Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation
Q64996451Inhibition of Mast Cell Degranulation With Cromolyn Sodium Exhibits Organ-Specific Effects in Polycystic Kidney (PCK) Rats.
Q24633724Liver and kidney disease in ciliopathies
Q41819809Loss of cilia causes embryonic lung hypoplasia, liver fibrosis, and cholestasis in the talpid3 ciliopathy mutant.
Q34091331Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.
Q84088659Measuring cilium-induced Ca2+ increases in cultured renal epithelia
Q36647210Mechanobiology of Ciliogenesis
Q28481462Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading
Q36527934Mechanosensitive Cl- secretion in biliary epithelium mediated through TMEM16A.
Q50182542MiR-433 and miR-22 dysregulations induce HDAC6 overexpression and ciliary loss in cholangiocarcinoma.
Q36410357MicroRNAs in biliary diseases.
Q26783579MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment
Q37809245Molecular Mechanisms of Biliary Development
Q37769923Molecular mechanisms of bile duct development
Q36559639Morphological and functional features of hepatic cyst epithelium in autosomal dominant polycystic kidney disease
Q35952274Neuronal ciliary signaling in homeostasis and disease
Q38092296Non-motile primary cilia as fluid shear stress mechanosensors
Q41898964Non-random distribution and sensory functions of primary cilia in vascular smooth muscle cells.
Q92157976Novel functions of the primary cilium in bone disease and cancer
Q38273327Novel therapeutic approaches to autosomal dominant polycystic kidney disease
Q37730964Osteocyte primary cilium and its role in bone mechanotransduction
Q39440062Pathobiology of biliary epithelia.
Q92532305Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases
Q34623557Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches
Q34860483Patients, cells, and organelles: the intersection of science and serendipity
Q36585455Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins
Q37145917Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
Q27008523Physiology of cholangiocytes
Q35660081Polycystic diseases in visceral organs
Q33949172Polycystic liver diseases.
Q27001174Polycystic liver diseases: advanced insights into the molecular mechanisms
Q37868328Polycystic liver diseases: congenital disorders of cholangiocyte signaling
Q28591325Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases
Q33894574Primary Cilia in Tumor Biology: The Primary Cilium as a Therapeutic Target in Cholangiocarcinoma
Q45932817Primary Cilium-Dependent Signaling Mechanisms.
Q30479846Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism.
Q34245120Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.
Q40003783Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes
Q38832224Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization
Q30530971Primary cilia-mediated mechanotransduction in human mesenchymal stem cells
Q47750425Primary cilia: Cell and molecular mechanosensors directing whole tissue function
Q37252102Primary cilia: cellular sensors for the skeleton
Q37994180Primary cilia: highly sophisticated biological sensors
Q34017092Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells
Q53096259Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow.
Q95822241Proceedings of the 21st International Bile Acid Meeting. October 7-14, 2010, Freiburg, Germany
Q35854986Protein composition and movements of membrane swellings associated with primary cilia
Q94363723RAPAMYCIN INCREASES LENGTH AND MECHANOSENSORY FUNCTION OF PRIMARY CILIA IN RENAL EPITHELIAL AND VASCULAR ENDOTHELIAL CELLS
Q30638114Real-time vascular mechanosensation through ex vivo artery perfusion
Q85887537Safety study of somatostatin analogue octreotide for autosomal dominant polycystic kidney disease in Japan
Q33606240Sensing a sensor: identifying the mechanosensory function of primary cilia
Q39426442Shear stress reverses dome formation in confluent renal tubular cells.
Q37347565Somatostatin signaling in neuronal cilia is critical for object recognition memory.
Q33809680Structural and functional analyses of liver cysts from the BALB/c-cpk mouse model of polycystic kidney disease
Q40867711TGR5 in the Cholangiociliopathies
Q37892281TGR5 in the biliary tree
Q37369328Targeting proteins to the ciliary membrane.
Q26852534The Liver and Polycystic Kidney Disease
Q92128065The Role of the Primary Cilium in Sensing Extracellular pH
Q60934459The Roles of Primary Cilia in Cardiovascular Diseases
Q39040911The ascending pathophysiology of cholestatic liver disease.
Q37781024The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
Q34717186The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).
Q39381392The cholangiocyte primary cilium in health and disease.
Q28000091The emerging role of Arf/Arl small GTPases in cilia and ciliopathies
Q37928761The mechanics of the primary cilium: an intricate structure with complex function
Q38019498The primary cilium as a novel extracellular sensor in bone
Q47681227The primary cilium as a signaling nexus for growth plate function and subsequent skeletal development.
Q38271916The primary cilium as sensor of fluid flow: new building blocks to the model. A review in the theme: cell signaling: proteins, pathways and mechanisms
Q37690035The primary cilium at a glance
Q37796679The primary cilium in different tissues-lessons from patients and animal models
Q36529245The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling
Q90312189The primary cilium: Its role as a tumor suppressor organelle
Q50944400The regulatory 1α subunit of protein kinase A modulates renal cystogenesis.
Q35082225The role of cilia in the regulation of bile flow
Q36850831The schistosome in the mammalian host: understanding the mechanisms of adaptation
Q38443908Therapeutic Targets in Polycystic Liver Disease
Q34024396Treatment strategies and clinical trial design in ADPKD
Q29547198When cilia go bad: cilia defects and ciliopathies

Search more.