The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification

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The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification is …
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scholarly articleQ13442814

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P819ADS bibcode2002PNAS...9914303V
P356DOI10.1073/PNAS.202332999
P3181OpenCitations bibliographic resource ID303536
P932PMC publication ID137879
P698PubMed publication ID12379742
P5875ResearchGate publication ID11080202

P50authorWim Van HulQ51558661
P2093author name stringFayez F Safadi
Steven N Popoff
Paul R Odgren
Sandy C Marks
Liesbeth Van Wesenbeeck
Carole A MacKay
Marina D'Angelo
P2860cites workBiology and action of colony--stimulating factor-1Q24310399
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
Osteoblasts from the toothless (osteopetrotic) mutation in the rat are unable to direct bone resorption by normal osteoclasts in response to 1,25-dihydroxyvitamin DQ71568467
CSF-1 treatment promotes angiogenesis in the metaphysis of osteopetrotic (toothless, tl) ratsQ71697637
Abnormalities in bone cell function and endochondral ossification in the osteopetrotic toothless ratQ71730898
Decreased growth hormone receptor expression in long bones from toothless (osteopetrotic) rats and restoration by treatment with colony-stimulating factor-1Q71880301
The skeletal effects of colony-stimulating factor-1 in toothless (osteopetrotic) rats: persistent metaphyseal sclerosis and the failure to restore subepiphyseal osteoclastsQ72689616
Interdependence of skeletal sclerosis and elevated circulating levels of 1,25-dihydroxyvitamin D in osteopetrotic (op and tl) ratsQ72857966
Reduced bone resorption in toothless (osteopetrotic) rats--an abnormality of osteoblasts related to their inability to activate osteoclast activity in vitroQ73185813
The toothless osteopetrotic rat has a normal vitamin D-binding protein-macrophage activating factor (DBP-MAF) cascade and chondrodysplasia resistant to treatments with colony stimulating factor-1 (CSF-1) and/or DBP-MAFQ78155254
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single geneQ24338885
RANK is essential for osteoclast and lymph node developmentQ24598872
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Isolation and characterization of a cDNA clone encoding for rat CSF-1 gene. Post-transcriptional repression occurs in myogenic differentiationQ28573814
Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expressionQ28577012
Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1Q28577629
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Thrombocytopenia in the toothless (osteopetrotic) rat and its rescue by treatment with colony-stimulating factor-1.Q33495764
Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouseQ33646429
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.Q36404187
Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgeneQ37265676
Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?Q40456221
Induction of macrophage production and proliferation by a purified colony stimulating factorQ40680967
Osteopetrosis in the toothless (tl) rat: Presence of osteoclasts but failure to respond to parathyroid extract or to be cured by infusion of spleen or bone marrow cells from normal littermatesQ40785900
Animal models of osteopetrosis: the impact of recent molecular developments on novel strategies for therapeutic interventionQ41105479
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.Q41121255
Synthesis of membrane- and matrix-bound colony-stimulating factor-1 by cultured osteoblastsQ41235519
Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursorsQ41607334
Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorptionQ41772601
The effects of colony-stimulating factor-1 on the number and ultrastructure of osteoclasts in toothless (tl) rats and osteopetrotic (op) miceQ42446856
Histochemistry and biochemistry of tartrate-resistant acid phosphatase (TRAP) and tartrate-resistant acid adenosine triphosphatase (TrATPase) in bone, bone marrow and spleen: implications for osteoclast ontogenyQ44135972
Colony-stimulating factor-1 injections improve but do not cure skeletal sclerosis in osteopetrotic (op) miceQ49282783
Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development.Q52170865
Actin mRNA isoforms are differentially sorted in normal osteoblasts and sorting is altered in osteoblasts from a skeletal mutation in the rat.Q52187181
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Correction by CSF-1 of defects in the osteopetrotic op/op mouse suggests local, developmental, and humoral requirements for this growth factor.Q52235117
Elevated 1,25-dihydroxyvitamin D3 and intestinal calbindin-D9k in the toothless rat.Q52242416
Ultrastructural evidence of abnormally short and maldistributed actin stress fibers in osteopetrotic (toothless) rat osteoblasts in situ after detergent perfusion.Q52524363
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.Q54137269
Administration of colony stimulating factor-1 to toothless osteopetrotic rats normalizes osteoblast, but not osteoclast, gene expressionQ54171353
The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruptionQ54264307
Insulin-like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) Immunoreactivity in Normal and Osteopetrotic (toothless,tl/tl) Rat TibiaQ56879967
Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) geneQ57849156
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the MouseQ67444875
Administration of colony stimulating factor-1 corrects some macrophage, dental, and skeletal defects in an osteopetrotic mutation (toothless, tl) in the ratQ68117985
Unerupted dentition secondary to congenital osteopetrosis in the Osborne-Mendel ratQ69780437
Molecular and biological properties of human macrophage growth factor, CSF-1Q70178521
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)14303-14308
P577publication date2002-10-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification
P478volume99

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cites work (P2860)
Q47326665A new histomorphometric method to assess growth plate chondrodysplasia and its application to the toothless (tl, Csf1(null)) osteopetrotic rat.
Q34064405Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
Q37057352Accelerating skin wound healing by M-CSF through generating SSEA-1 and -3 stem cells in the injured sites
Q33239022Activation of genes for growth factor and cytokine pathways late in chondrogenic differentiation of ATDC5 cells
Q33289959Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency
Q38978837CSF-1 regulation of osteoclastogenesis for tooth eruption
Q37762345CSF-1, IGF-1, and the control of postnatal growth and development
Q37472189Cellular and molecular basis of tooth eruption
Q38805471Characterization and comparison of osteoblasts derived from mouse embryonic stem cells and induced pluripotent stem cells
Q35849487Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro
Q36241623Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis
Q40264908Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
Q37995562FMS Kinase Inhibitors: Current Status and Future Prospects.
Q54455363False-positive beta-galactosidase staining in osteoclasts by endogenous enzyme: studies in neonatal and month-old wild-type mice.
Q35552797Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
Q64880776Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis.
Q40361386Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor
Q33831246Impaired vibration of auditory ossicles in osteopetrotic mice
Q63915886Macrophages and Cardiovascular Health
Q37146973Mechanisms of tooth eruption and orthodontic tooth movement
Q35577477Metchnikoff's policemen: macrophages in development, homeostasis and regeneration
Q42796548Molecular and structural assessment of alveolar bone during tooth eruption and function in the miniature pig, sus scrofa
Q46294640Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model
Q29547556Osteoclast differentiation and activation
Q52652877Osteoclast inhibition impairs chondrosarcoma growth and bone destruction.
Q28511207Osteoclast stimulatory transmembrane protein (OC-STAMP), a novel protein induced by RANKL that promotes osteoclast differentiation
Q24323917PAMM: a redox regulatory protein that modulates osteoclast differentiation
Q36029217Paget disease of bone
Q38006389Pathogenesis of Paget disease of bone.
Q36298761Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing
Q58699773Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Locus
Q98188932Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
Q37283089Refined genomic localization of the genetic lesion in the osteopetrosis (op) rat and exclusion of three positional and functional candidate genes, Clcn7, Atp6v0c, and Slc9a3r2.
Q33820660Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor
Q42106005Regulation of SFRP-1 expression in the rat dental follicle
Q37681080Regulation of matrix metalloproteinase-9 protein expression by 1α, 25-(OH)₂D₃ during osteoclast differentiation.
Q38071918Role and regulation of vascularization processes in endochondral bones
Q28576496Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections
Q55051527Sost Deficiency does not Alter Bone's Lacunar or Vascular Porosity in Mice.
Q40151249The Role of the Immune System Beyond the Fight Against Infection.
Q37017831The cast of clasts: catabolism and vascular invasion during bone growth, repair, and disease by osteoclasts, chondroclasts, and septoclasts
Q33873578The critical role of IL-34 in osteoclastogenesis
Q34087187The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells
Q38260567Tissue macrophage identity and self-renewal.
Q36829147Trophic macrophages in development and disease
Q24796821Variations in genome-wide gene expression in identical twins - a study of primary osteoblast-like culture from female twins discordant for osteoporosis

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