Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

scientific article published on May 12, 2003

Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20022190
P953full work available at URLhttps://rupress.org/jem/article-pdf/197/10/1377/1142145/jem197101377.pdf
https://europepmc.org/articles/PMC2193780
https://europepmc.org/articles/PMC2193780?pdf=render
https://rupress.org/jem/article-pdf/197/10/1377/1707974/jem197101377.pdf
P932PMC publication ID2193780
P698PubMed publication ID12743174
P5875ResearchGate publication ID10763646

P50authorCarol E. SchraderQ41870482
P2093author name stringJanet Stavnezer
Joycelyn Vardo
P2860cites workCancer ResearchQ326097
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPaseQ27635053
High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimerQ27936605
Eukaryotic DNA mismatch repairQ27939116
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationQ28208979
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing overQ28282791
AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingQ28366125
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targetingQ28506440
Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsQ28513507
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymesQ28585862
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modificationsQ28586687
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.Q33952028
The many faces of mismatch repair in meiosisQ33984289
Roles for mismatch repair factors in regulating genetic recombinationQ34057743
MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesisQ34386079
DNA sequences at immunoglobulin switch region recombination sitesQ34963864
Immunoglobulin genes: generating diversity with AID and UNG.Q34990524
DNA-dependent protein kinase activity is not required for immunoglobulin class switchingQ36371923
Ku70 is required for late B cell development and immunoglobulin heavy chain class switchingQ36401127
Two new isotype-specific switching activities detected for Ig class switchingQ36709872
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switchQ36776415
Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosisQ38344945
Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiaeQ40023936
Antibody class switchingQ41134290
Ku80 is required for immunoglobulin isotype switchingQ41821763
Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.Q42676262
The AID enzyme induces class switch recombination in fibroblastsQ42818062
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient miceQ44194766
IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cellsQ77995587
Alternative end joining during switch recombination in patients with ataxia-telangiectasiaQ78022313
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
immunologyQ101929
genetic recombinationQ211675
MutS homolog 2Q14911693
MutL homolog 1Q14911713
P304page(s)1377–1383
P577publication date2003-05-12
2003-05-19
P1433published inJournal of Experimental MedicineQ3186912
P1476titleMlh1 can function in antibody class switch recombination independently of Msh2
Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2
P478volume197

Reverse relations

cites work (P2860)
Q36211150A role for the MutL mismatch repair Mlh3 protein in immunoglobulin class switch DNA recombination and somatic hypermutation
Q34118000AID and somatic hypermutation.
Q36173942AIDing antibody diversity by error-prone mismatch repair
Q36954874Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions
Q28513971Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
Q36231123Antibody class switch recombination: roles for switch sequences and mismatch repair proteins
Q36540495Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases
Q28269740Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
Q36316915Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications
Q36015019DNA deamination in immunity
Q36229513DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
Q34595025DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
Q28508643Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions
Q28589828Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification
Q35671715Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (hyper-IgM syndromes).
Q38735124MBD4 Facilitates Immunoglobulin Class Switch Recombination
Q36403873Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor
Q36037736Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences
Q34773522Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining
Q35605313Mismatch-mediated error prone repair at the immunoglobulin genes
Q28586272Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination
Q44600123Mutations in AID and UNG extend the function of AID
Q40240123Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination
Q35576430Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
Q34068165PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
Q37106800Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability
Q34115234Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair
Q53589401Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination.
Q35830410The role of the non-homologous end-joining pathway in lymphocyte development
Q36945144Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

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