Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3

scientific journal article

Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2012.07.017
P3181OpenCitations bibliographic resource ID2485408
P932PMC publication ID3432687
P698PubMed publication ID22841643
P5875ResearchGate publication ID230581059

P2093author name stringMegan Bowers
Alexandra L. Joyner
Susan Mackem
Xiaozhong Bao
Elyn Riedel
Zhimin Lao
Liane Eng
Rowena K. Turnbull
P2860cites workSonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3Q22009022
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limbQ22253250
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signalingQ24298606
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitroQ24315704
Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signalingQ24672542
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutationQ28139169
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog functionQ28209365
A re-examination of proximodistal patterning during vertebrate limb developmentQ28216626
A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 geneQ28263330
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identitiesQ28277481
Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1Q28295825
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.Q52095015
Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.Q52115170
Expression pattern of Irx1 and Irx2 during mouse digit development.Q52132021
Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity.Q52181922
Expression profile of Gli family members and Shh in normal and mutant mouse limb development.Q52191354
Positional signalling and specification of digits in chick limb morphogenesisQ59053495
The number of polarizing region cells required to specify additional digits in the developing chick wingQ59080132
Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the Sonic hedgehog pathwayQ73685420
High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletionQ77440365
Carboxy-terminally truncated Gli3 proteins associate with SmadsQ77647853
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular developmentQ81159312
Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and developmentQ28301976
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud developmentQ28473604
Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterningQ28504770
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb developmentQ28505407
Gli1 can rescue the in vivo function of Gli2Q28506239
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationQ28507411
All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3Q28508067
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse developmentQ28509768
Polydactyly and ectopic ZPA formation in Alx-4 mutant miceQ28585223
Some distal limb structures develop in mice lacking Sonic hedgehog signalingQ28587394
The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterningQ28590978
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiationQ28591169
Sonic hedgehog mediates the polarizing activity of the ZPAQ29616565
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarityQ29616632
Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb BudQ30039622
Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development.Q32062149
Hox gene expression in limbs: colinearity by opposite regulatory controls.Q33854967
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identityQ34146314
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesisQ35801438
Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limbQ36178672
Tamoxifen-dependent, inducible Hoxb6CreERT recombinase function in lateral plate and limb mesoderm, CNS isthmic organizer, posterior trunk neural crest, hindgut, and tailbudQ36355884
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural developmentQ36599922
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limbQ36919931
How do we get a perfect complement of digits?Q37232188
Hedgehog signaling in development and cancer.Q37350250
Interdigital regulation of digit identity and homeotic transformation by modulated BMP signalingQ39542358
Specification of cell fate along the proximal-distal axis in the developing chick limb bud.Q40238405
Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb developmentQ40371973
Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling.Q42734295
Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox geneQ44019642
A staging system for mouse limb developmentQ46117384
Extra-toes: anew mutant gene causing multiple abnormalities in the mouse.Q46883382
Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identityQ47176645
Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb developmentQ47263316
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh.Q47719346
A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud.Q51795148
Integration of growth and specification in chick wing digit-patterning.Q51961530
Genetic interaction of Gli3 and Alx4 during limb development.Q52046589
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectGLI-Kruppel family member GLI2Q14886550
GLI-Kruppel family member GLI3Q14886933
P304page(s)110–124
P577publication date2012-10-01
P1433published inDevelopmental BiologyQ3025402
P1476titleLimb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3
P478volume370

Reverse relations

cites work (P2860)
Q37715286A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.
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Q35950995Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway
Q92675264Characterization of Krt19 CreERT allele for targeting the nucleus pulposus cells in the postnatal mouse intervertebral disc
Q34464541Cis-regulatory control of human GLI2 expression in the developing neural tube and limb bud.
Q55417331Control of Hedgehog Signalling by the Cilia-Regulated Proteasome.
Q39173453Coordination of limb development by crosstalk among axial patterning pathways.
Q38824254Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog
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Q92989376GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
Q64245029Gli Proteins: Regulation in Development and Cancer
Q100418580Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks
Q38524647Hedgehog and Resident Vascular Stem Cell Fate
Q38220772Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives
Q46984360Heterochrony in the regulation of the developing marsupial limb
Q48158969IFT56 regulates vertebrate developmental patterning by maintaining IFTB complex integrity and ciliary microtubule architecture
Q39119924John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?
Q61797127Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells
Q42119108Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants
Q38729673Non-melanoma skin cancer: new and future synthetic drug treatments.
Q100378824Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes
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Q54984935Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.
Q39178653Sonic Hedgehog Signaling in Limb Development
Q37287061Sonic hedgehog signaling directly targets Hyaluronic Acid Synthase 2, an essential regulator of phalangeal joint patterning
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Q37387761Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.
Q50607969Sufu and Kif7 in limb patterning and development.
Q35637290Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin
Q36791953T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number
Q37266527Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions
Q38215036Transcriptional regulation of graded Hedgehog signaling

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