Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss

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Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2007.070068
P932PMC publication ID1934525
P698PubMed publication ID17620368
P5875ResearchGate publication ID6218301

P50authorHamish S. ScottQ53110183
Robert K. ShepherdQ53396446
P2093author name stringQingyu Wu
Justin Tan
Michel Guipponi
Maria Clarke
Ping Z F Cannon
Pauline Crewther
Lauren Donley
P2860cites workInsertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafnessQ24290692
From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30Q24298272
Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing lossQ24301501
Mutations of MYO6 are associated with recessive deafness, DFNB37Q24532041
Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)Q24533372
Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9Q24534496
MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing lossQ24535864
Novel mutations of TMPRSS3 in four DFNB8/B10 families segregating congenital autosomal recessive deafnessQ24680175
Novel missense mutations of TMPRSS3 in two consanguineous Tunisian families with non-syndromic autosomal recessive deafnessQ28207545
Mutations in the TMPRSS3 gene are a rare cause of childhood nonsyndromic deafness in Caucasian patientsQ28208859
Mutations in the myosin VIIA gene cause non-syndromic recessive deafnessQ28239749
The autosomal recessive isolated deafness, DFNB2, and the Usher 1B syndrome are allelic defects of the myosin-VIIA geneQ28239757
A novel TMPRSS3 missense mutation in a DFNB8/10 family prevents proteolytic activation of the proteinQ28261878
Control of peripheral nerve myelination by the beta-secretase BACE1Q28264800
Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearingQ28292052
Polypeptide composition of the mammalian tectorial membraneQ28300248
Thyroid hormone receptor beta is essential for development of auditory functionQ28510090
Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochleaQ28580648
Distortion product otoacoustic emissions and outer hair cell defects in the hyt/hyt mutant mouseQ28590657
Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing lossQ28595088
Chronic depolarization enhances the trophic effects of brain-derived neurotrophic factor in rescuing auditory neurons following a sensorineural hearing loss.Q30499424
Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.Q34469642
Molecular mechanisms of age-related hearing lossQ34688008
Thyroid functions of mouse cathepsins B, K, and L.Q35019251
Age-related hearing loss: current researchQ35539902
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinaseQ37073731
Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine proteaseQ37377341
Genetic epidemiology of hearing impairmentQ37519270
Assessment of the genetic causes of recessive childhood non-syndromic deafness in the UK - implications for genetic testingQ40373249
Hearing loss in athyroid pax8 knockout mice and effects of thyroxine substitutionQ42457578
Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors.Q48692469
Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells.Q50458423
Contribution of BK Ca2+-activated K+ channels to auditory neurotransmission in the Guinea pig cochlea.Q50484630
Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems.Q50496402
Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function.Q50504448
Hearing loss and cochlear abnormalities in the congenital hypothyroid (hyt/hyt) mouse.Q50518773
Effects of hypothyroidism on the structural development of the organ of Corti in the rat.Q50599195
Periods of sensitivity to thyroid hormone during the development of the organ of Corti.Q52263776
Type II transmembrane serine proteasesQ73273646
P4510describes a project that usesImageQuantQ112270642
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttransmembrane proteinQ424204
hearing lossQ16035842
HepsinQ21981170
P304page(s)608-616
P577publication date2007-07-09
P1433published inThe American Journal of PathologyQ4744259
P1476titleMice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss
P478volume171