Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1 is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...5.9367K
P356DOI10.1371/JOURNAL.PONE.0009367
P3181OpenCitations bibliographic resource ID1983846
P932PMC publication ID2826413
P698PubMed publication ID20186336
P5875ResearchGate publication ID41579021

P50authorRejko KrügerQ30500739
Olaf RiessQ83912532
Hartwig WolburgQ32419952
P2093author name stringDirk Woitalla
Tassula Proikas-Cezanne
Brigitte Maurer
Zemfira Gizatullina
Jens Waak
Philipp J. Kahle
Frank N. Gellerich
Nicole Kieper
Guido Krebiehl
Lena F. Burbulla
Sabine Ruckerbauer
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesQ23757358
DJ-1 has a role in antioxidative stress to prevent cell deathQ24306633
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagyQ24318098
High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagyQ24318282
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismQ24321359
WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagyQ24322858
Mitochondrial localization of DJ-1 leads to enhanced neuroprotectionQ24324226
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
Fission and selective fusion govern mitochondrial segregation and elimination by autophagyQ24652230
Selective degradation of mitochondria by mitophagyQ24658163
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell deathQ24676936
Formation of a Stabilized Cysteine Sulfinic Acid Is Critical for the Mitochondrial Function of the Parkinsonism Protein DJ-1Q27653346
Autophagy fights disease through cellular self-digestionQ27860902
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceQ28131756
Pathways to ParkinsonismQ28202942
A block of autophagy in lysosomal storage disordersQ28252016
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's diseaseQ28257086
The roles of intracellular protein-degradation pathways in neurodegenerationQ28269322
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during agingQ28472271
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Q28593258
How to interpret LC3 immunoblottingQ29614175
Autophagy genes are essential for dauer development and life-span extension in C. elegansQ29614180
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutantsQ29615627
The PINK1/Parkin pathway regulates mitochondrial morphologyQ29615641
Disruption of fusion results in mitochondrial heterogeneity and dysfunctionQ29616566
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by ParkinQ29617063
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in DrosophilaQ29617091
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkinQ29622838
Control of autophagy initiation by phosphoinositide 3-phosphatase JumpyQ30489519
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cellsQ67902824
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndromeQ71106292
Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death executionQ73216536
Energetic depression caused by mitochondrial dysfunctionQ76377719
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonismQ79249169
Lysosomal storage diseases as disorders of autophagyQ79827971
Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1Q79855134
Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cellsQ33341058
Complex patterns of mitochondrial dynamics in human pancreatic cells revealed by fluorescent confocal imagingQ33433158
Autophagosome formation in mammalian cellsQ33964242
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotectionQ33998125
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseasesQ34628278
ROS, mitochondria and the regulation of autophagyQ34679713
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localizationQ34836156
Mitophagy in yeast occurs through a selective mechanismQ34837659
Present and future drug treatment for Parkinson's diseaseQ35484805
Mitochondria take center stage in aging and neurodegenerationQ36264218
Signalling and autophagy regulation in health, aging and diseaseQ36594286
Impact of recent genetic findings in Parkinson's diseaseQ36874881
Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's diseaseQ36952897
Regulation of mitochondrial fusion and divisionQ36980993
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responsesQ37061628
Identification of Atg5-dependent transcriptional changes and increases in mitochondrial mass in Atg5-deficient T lymphocytes.Q37079467
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and diseaseQ37126849
Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the diseaseQ37151410
Mitochondrial dysfunction in neurodegenerative diseases.Q37322156
Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic modelsQ37356319
Turnover of organelles by autophagy in yeastQ37514587
Mitochondria and energetic depression in cell pathophysiologyQ37535535
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth.Q39704890
Silencing DJ-1 reveals its contribution in paraquat-induced autophagy.Q39854932
Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stressQ39860196
Assessing mammalian autophagy by WIPI-1/Atg18 puncta formation.Q39886256
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).Q40515980
In search of an "autophagomometer".Q46027342
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's diseaseQ46683999
Mitochondrial aberrations in mucolipidosis Type IV.Q48390239
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectParkinson's diseaseQ11085
mitochondrionQ39572
autophagyQ288322
Parkinson disease (autosomal recessive, early onset) 7Q21989850
P304page(s)e9367
P577publication date2010-02-23
P1433published inPLOS OneQ564954
P1476titleReduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1
P478volume5

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