Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory

scientific journal article

Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1044-7431(03)00025-3
P698PubMed publication ID12799133

P50authorHuda ZoghbiQ1633764
J. David SweattQ57077183
Velia FowlerQ67189313
P2093author name stringRichard Paylor
Bisong Xu
Patrick R. Cox
P2860cites workEnhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 proteinQ22008543
Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologsQ22011210
Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neuronsQ24682526
A role of actin filament in synaptic transmission and long-term potentiationQ28144564
Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out miceQ28586975
The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1Q28589800
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in miceQ29616222
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile miceQ30500685
Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle.Q33874993
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampusQ33902823
Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?Q34390023
Strain-dependent differences in LTP and hippocampus-dependent memory in inbred miceQ35040115
Myosin heavy chains IIa and IId are functionally distinct in the mouseQ36255427
Thin filaments elongate from their pointed ends during myofibril assembly in Drosophila indirect flight muscle.Q36294188
High actin concentrations in brain dendritic spines and postsynaptic densitiesQ36325303
Induction of long-term potentiation is associated with major ultrastructural changes of activated synapsesQ37458890
Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth coneQ39291439
Rapid actin-based plasticity in dendritic spinesQ41035734
Regulation of actin filament length in erythrocytes and striated muscle.Q41099649
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studiesQ41574239
Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesisQ42689585
Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actinQ42762718
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytesQ43941100
Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar developmentQ46179548
Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrilsQ46491655
Defining actin filament length in striated muscle: rulers and caps or dynamic stability?Q46491682
Actin dynamics at pointed ends regulates thin filament length in striated muscleQ46871996
Immunocytochemical localization of actin in dendritic spines of the cerebral cortex using colloidal gold as a probeQ48454674
Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors.Q48493391
Math1 is essential for genesis of cerebellar granule neuronsQ48594976
Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation.Q48857728
Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses.Q51101104
DBA/2 and C57BL/6 mice differ in contextual fear but not auditory fear conditioning.Q51132237
The use of behavioral test batteries: effects of training history.Q51191825
Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses.Q52167512
Spine changes associated with long-term potentiationQ58410549
Tropomodulin increases the critical concentration of barbed end-capped actin filaments by converting ADP.P(i)-actin to ADP-actin at all pointed filament endsQ73212015
P433issue1
P921main subjectlong-term potentiationQ1805481
Tropomodulin 2Q21990747
P304page(s)1–12
P577publication date2003-05-01
P1433published inMolecular and Cellular NeuroscienceQ6895985
P1476titleMice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory
P478volume23

Reverse relations

cites work (P2860)
Q44722196A constraint on cAMP signaling
Q33364858A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity.
Q38823715Actin cytoskeleton in dendritic spine development and plasticity.
Q38692012Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function.
Q36733674Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development
Q47265042Characterizing interaction forces between actin and proteins of the tropomodulin family reveals the presence of the N-terminal actin-binding site in leiomodin.
Q39345117Dendritic Actin Cytoskeleton: Structure, Functions, and Regulations
Q51039723Differences in hippocampal protein levels between C57Bl/6J, PWD/PhJ, and Apodemus sylvaticus are paralleled by differences in spatial memory.
Q90067858Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use
Q28574761Effects of oestrogen on trigeminal ganglia in culture: implications for hormonal effects on migraine
Q30528041Elimination of the vesicular acetylcholine transporter in the forebrain causes hyperactivity and deficits in spatial memory and long-term potentiation
Q27009274Genes and signaling pathways involved in memory enhancement in mutant mice
Q39895735Mutations changing tropomodulin affinity for tropomyosin alter neurite formation and extension
Q38816657Mutations in THAP11 cause an inborn error of cobalamin metabolism and developmental abnormalities
Q36335668Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior
Q28583581Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction
Q42776470Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells
Q33598667Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes
Q33842711S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours
Q58018244Second report on chicken genes and chromosomes 2005
Q37889023Structural modulation of dendritic spines during synaptic plasticity
Q36083476The dopamine hypothesis of drug addiction: hypodopaminergic state.
Q47594962The neuronal and actin commitment: Why do neurons need rings?
Q36398941Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle.
Q57290403Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation
Q37026817Tropomodulin isoforms utilize specific binding functions to modulate dendrite development
Q57816805Tropomodulin's Actin-Binding Abilities Are Required to Modulate Dendrite Development
Q36640510Tropomodulins and tropomyosins: working as a team
Q34590095Tropomodulins are negative regulators of neurite outgrowth.
Q38001405Tropomodulins: pointed-end capping proteins that regulate actin filament architecture in diverse cell types.
Q37365595Tropomyosin-binding properties modulate competition between tropomodulin isoforms