A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

scientific journal article

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1019613304
P356DOI10.1038/78140
P698PubMed publication ID10932191

P2093author name stringP. M. Nolan
A. Erven
X. Liu
K. P. Steel
S. D. Brown
P. Mburu
A. Isaacs
A. Kiernan
C. Nickols
C. Thaung
C. Thornton
C. Wells
D. Brooker
D. Rogers
E. M. Fisher
E. Whitehill
I. C. Gray
J. A. Stevenson
J. Hagan
J. Hunter
J. L. Guenet
J. Martin
J. Peters
K. Davies
K. Pickford
L. Vizor
M. Browne
M. Hewitt
M. Nasse
M. Strivens
N. Spurr
P. Glenister
P. Roby
R. Arkell
R. Hardisty
R. Sadri
R. Selley
R. Washbourne
S. Greenaway
S. McCormack
S. Rastan
S. Voegeling
T. Hough
Z. Tymowska-Lalanne
P2860cites workLarge numbers of mice established by in vitro fertilization with cryopreserved spermatozoa: implications and applications for genetic resource banks, mutagenesis screens, and mouse backcrossesQ30780214
Mouse mutagenesis-systematic studies of mammalian gene functionQ32022434
Mouse ENU mutagenesisQ33724129
Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessmentQ34441265
Random mutagenesis screen for dominant behavioral mutations in miceQ38553450
Combining mutagenesis and genomics in the mouse--closing the phenotype gap.Q40921551
Startle habituation and sensorimotor gating in schizophrenia and related animal modelsQ41443315
Genome-wide, large-scale production of mutant mice by ENU mutagenesis.Q43520565
Effect of cryoprotectants on the survival of follicles in frozen mouse ovaries.Q52194634
Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouseQ72110918
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
Chromodomain helicase DNA binding protein 7Q15311456
Cadherin, EGF LAG seven-pass G-type receptor 1Q21494076
F-box protein 11Q21495687
Zinc finger protein ZIC 2Q21984265
P304page(s)440–443
P577publication date2000-08-01
P1433published inNature GeneticsQ976454
P1476titleA systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
P478volume25

Reverse relations

cites work (P2860)
Q52095673A Novel Ataxic Mutant Mouse Line Having Sensory Neuropathy Shows Heavy Iron Deposition in Kidney.
Q50486350A compendium of mouse knockouts with inner ear defects.
Q30532357A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion.
Q30542925A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.
Q24798758A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development
Q35140803A forward-genetic approach for analysis of the immune system
Q30841444A gene-driven ENU-based approach to generating an allelic series in any gene
Q31039073A gene-driven approach to the identification of ENU mutants in the mouse
Q35729853A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse
Q30743647A genomewide screening of N-ethyl-N-nitrosourea-mutagenized mice for musculoskeletal phenotypes☆
Q43199676A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment
Q28594074A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice
Q57667437A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to aCol2a1mutation
Q28483790A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation
Q74191885A mutant mouse menagerie
Q34468672A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen
Q48256073A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.
Q41513620A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways
Q92533624A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
Q34549521A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice
Q46796125A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption.
Q60955662A radiation hybrid transcript map of the mouse genome
Q33260768A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud.
Q39693546A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability
Q24798797A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor
Q24812780ARTS: a web-based tool for the set-up of high-throughput genome-wide mapping panels for the SNP genotyping of mouse mutants
Q35870519Abnormal pigmentation in hypomelanosis of Ito and pigmentary mosaicism: the role of pigmentary genes
Q42501734Abnormal sebaceous gland differentiation in 10 kittens ('sebaceous gland dysplasia') associated with generalized hypotrichosis and scaling
Q35364326Activin B antagonizes RhoA signaling to stimulate mesenchymal morphology and invasiveness of clear cell renal cell carcinomas
Q36309428Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity
Q46827741Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression
Q38079493Activin, neutrophils, and inflammation: just coincidence?
Q36190270Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer
Q24307781Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium
Q57147628An -Ethyl--Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion
Q24651733An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy
Q28588584An ENU-induced mutation in the Ankrd11 gene results in an osteopenia-like phenotype in the mouse mutant Yoda
Q34031998An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae
Q34618250An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse
Q52608849An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome.
Q51812502An siRNA-based screen in C2C12 myoblasts identifies novel genes involved in myogenic differentiation.
Q30485081Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss
Q29615723Animal models of human disease: zebrafish swim into view
Q37032354Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography
Q36533740Approaches to lipid metabolism gene identification and characterization in the postgenomic era.
Q35830418Artemis sheds new light on V(D)J recombination
Q34635853Assessing antidepressant activity in rodents: recent developments and future needs
Q45240677Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines
Q34065954Auditory and vestibular mouse mutants: models for human deafness
Q34576536Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5
Q30500276Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse
Q35586667Behavioural screening in mutagenised mice—in search for novel animal models of psychiatric disorders
Q52119252Building-blocks of embryogenesis.
Q38084235Cancer of mice and men: old twists and new tails
Q34186639Capitalizing on large-scale mouse mutagenesis screens
Q37006621Centralized mouse repositories
Q34989563Characterization of Sleeping Beauty transposition and its application to genetic screening in mice
Q44268455Characterization of trimethylpsoralen as a mutagen for mouse embryonic stem cells
Q31881396Chemical genetics: ligand-based discovery of gene function
Q37232958Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior
Q28206335Chromosomal microdeletions: dissecting del22q11 syndrome
Q36462154Cloned mice and embryonic stem cell establishment from adult somatic cells.
Q37494507Cognitive assessment of mice strains heterozygous for cell-adhesion genes reveals strain-specific alterations in timing
Q33285195Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease
Q37115953Comparative genomics for detecting human disease genes
Q53962268Comparative transcriptome and histological analyses provide insights into the prenatal skin pigmentation in goat (Capra hircus).
Q35092551Congenic mice: cutting tools for complex immune disorders
Q24644570Constitutional downregulation of SEMA5A expression in autism
Q50593343Cooperative effect of ribosomal protein s19 and Pim-1 kinase on murine c-Myc expression and myeloid/erythroid cellularity.
Q50304324Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis
Q63977492Current Awareness on Comparative and Functional Genomics
Q26785773Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing
Q37298023Cytoplasmic dynein heavy chain: the servant of many masters
Q38960929Decoding sORF translation - from small proteins to gene regulation
Q46112482Defining brain wiring patterns and mechanisms through gene trapping in mice.
Q47259668Design and Evaluation of a Robotic Device for Automated Tail Vein Cannulations in Rodent Models
Q37023265Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
Q42544712Diffusion microscopic MRI of the mouse embryo: Protocol and practical implementation in the splotch mouse model
Q24652124Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development
Q36265438Discovery genetics: serendipity in basic research
Q27002466Dissecting immunity by germline mutagenesis
Q37060493Dissecting innate immunity by germline mutagenesis
Q28513404Dissecting the genetic complexity of human 6p deletion syndromes by using a region-specific, phenotype-driven mouse screen
Q30440634Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features
Q55041356EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.
Q33964080ENU Mutagenesis in the Mouse
Q30474524ENU induced single mutation locus on chr 16 leads to high-frequency hearing loss in mice
Q28594698ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
Q43937639ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis
Q35636403ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice
Q33732572ENU-Based Gene-Driven Mutagenesis in the Mouse: A Next-Generation Gene-Targeting System
Q33543443ENU-induced mutant mice for a next-generation gene-targeting system
Q34457048ENU-induced phenovariance in mice: inferences from 587 mutations
Q36016473EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation
Q36684795Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking.
Q37621089Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation.
Q33510181Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes
Q28509225Effects of G-protein mutations on skin color
Q42212782Effects of chronic hepatitis C genotype 1 and 4 on serum activins and follistatin in treatment naïve patients and their correlations with interleukin-6, tumour necrosis factor-α, viral load and liver damage.
Q33220908Efficient and fast targeted production of murine models based on ENU mutagenesis
Q33930324Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice.
Q25255702Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice
Q38469448Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis
Q92881931Efficient genome-wide first-generation phenotypic screening system in mice using the piggyBac transposon
Q40763346Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation
Q46976638Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens
Q30490127Evaluation of animal models of neurobehavioral disorders
Q24305929Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation
Q24791942Focusing on the genetics of hearing: you ain't heard nothin' yet.
Q92609296Forward genetic approach for behavioral neuroscience using animal models
Q37980649Forward genetic approaches to understanding complex behaviors.
Q46683464From ENU mutagenesis to population genetics
Q36005259From guts to brains: using zebrafish genetics to understand the innards of organogenesis
Q38578808From mice to men: lessons from mutant ataxic mice
Q34462487Full-speed mammalian genetics: in vivo target validation in the drug discovery process
Q46905044Functional analysis of secreted and transmembrane proteins critical to mouse development.
Q30597227Functional and genetic analysis of choroid plexus development in zebrafish
Q33894561Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15.
Q38345938Functional annotation of mouse mutations in embryonic stem cells by use of expression profiling
Q35167516Functional genomics and proteomics: charting a multidimensional map of the yeast cell
Q34609125Functional genomics approaches to understanding brain disorders
Q35155809Functional genomics of sleep.
Q34303207Functional genomics of the murine immune system
Q35882819Functional genomics tools for the analysis of zebrafish pigment
Q55014626G-protein-coupled receptor signaling and neural tube closure defects.
Q34375846Gene targeting reveals a role for the glutamate receptors mGluR5 and GluR2 in learning and memory
Q89175920Generation and Identification of Mutations Resulting in Chronic and Age-Related Phenotypes in Mice
Q57198013Generation of ENU-Induced Mouse Mutants with Hypocholesterolemia: Novel Tools for Dissecting Plasma Lipoprotein Homeostasis
Q50537421Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.
Q46158738Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models
Q43729214Generation of precise point mutation mice by footprintless genome modification.
Q80448597Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system
Q36825572Genetic architecture of quantitative traits in mice, flies, and humans
Q38610506Genetic influences on the human oral microbiome
Q35813847Genetic insights into the morphogenesis of inner ear hair cells.
Q34435156Genetics and genomics in neuropsychopharmacology: the impact on drug discovery and development
Q35145888Genetics and genomics of behavioral and psychiatric disorders
Q35963838Genetics of dark skin in mice
Q36314245Genetics of graviperception in animals.
Q34158811Genetics of sensory mechanotransduction
Q44573145Genetics: a balancing act.
Q37763941Genome-wide ENU mutagenesis for the discovery of novel male fertility regulators
Q34376881Genome-wide ENU mutagenesis to reveal immune regulators
Q36769182Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition
Q43520565Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
Q45187730Genomewide two-generation screens for recessive mutations by ES cell mutagenesis
Q53502363Genomics. Beyond the book of life.
Q74098267Genomics: saviour or millstone?
Q33881293Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome
Q42231754Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons.
Q28202486High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
Q52601624High-throughput mouse phenomics for characterizing mammalian gene function.
Q34156586High-throughput mouse phenotyping
Q48537271Histomorphological Phenotyping of the Adult Mouse Brain
Q35538187Human and animal models of V(D)J recombination deficiency
Q45041079Hypercholesterolemia in ENU-induced mouse mutants
Q28589778Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis
Q24808964Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique
Q46717321Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7.
Q44624383Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast
Q35937612Identifying early vascular genes through gene trapping in mouse embryonic stem cells
Q50904385Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice.
Q35994005Implementing large-scale ENU mutagenesis screens in North America
Q34292427In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice
Q37598783Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes
Q28259871Insertional mutagenesis in mice: new perspectives and tools
Q24803197Intraocular pressure in genetically distinct mice: an update and strain survey
Q30488888Joint mouse-human phenome-wide association to test gene function and disease risk
Q38035234Large-scale mouse knockouts and phenotypes
Q36414964Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.
Q34257296Linking yeast Gcn5p catalytic function and gene regulation using a quantitative, graded dominant mutant approach
Q35008497Long-term experiment to study the development, interaction, and influencing factors of DEXA parameters
Q30434519Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis
Q37550614Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
Q29619081Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Q35119688Manipulation of the mouse genome: a multiple impact resource for drug discovery and development
Q92110199Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis
Q92709644Mice with an autosomal dominant Charcot-Marie-Tooth type 2O disease mutation in both dynein alleles display severe moto-sensory phenotypes
Q27024434Modelling age-related metabolic disorders in the mouse
Q33903868Modifier screens in the mouse: time to move forward with reverse genetics
Q34613926Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus.
Q36586217Molecular mechanisms of midfacial developmental defects
Q38371715Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse
Q34258471Mouse genomics: making sense of the sequence
Q24631734Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project
Q36569492Mouse models as a tool to unravel the genetic basis for human otitis media
Q27491017Mouse models for human otitis media
Q35172443Mouse models for neurological disease
Q34140872Mouse models of blood pressure regulation and hypertension
Q45243964Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development
Q55034919Mouse mutagenesis on target.
Q42941345Mouse mutagenesis with the chemical supermutagen ENU.
Q34426092Mouse-based phenogenomics for modelling human disease.
Q31125643Mutagenesis strategies for identifying novel loci associated with disease phenotypes
Q27346517Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice
Q34459252Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables
Q28586559Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media
Q89966234Mutation in Fbxo11 Leads to Altered Immune Cell Content in Jeff Mouse Model of Otitis Media
Q28184694Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse
Q28512322Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation
Q27329518Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes
Q28534250Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice
Q34600929Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans
Q28302883Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition
Q28546036N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models
Q37231400N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels
Q33940306N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express
Q33244414N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors
Q30463349New insights into behaviour using mouse ENU mutagenesis
Q28589837New semidominant mutations that affect mouse development
Q33765741Next-generation mammalian genetics toward organism-level systems biology
Q34547272Novel approaches for identifying genes regulating lymphocyte development and function
Q27333508Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Q39769149Novel method for high-throughput phenotyping of sleep in mice.
Q46797404Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program
Q30600757Novel mutations in human and mouse SCN4A implicate AMPK in myotonia and periodic paralysis
Q37798972Now and future of mouse mutagenesis for human disease models
Q34133340Nuts and bolts of psychiatric genetics: building on the Human Genome Project
Q30355710Optical coherence tomography for embryonic imaging: a review.
Q30453755Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease
Q33302384PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice
Q34937350Pathbase: a database of mutant mouse pathology
Q36974098Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis.
Q34042381Perspectives for vascular genomics
Q36039949Phenotype-first screening for the identification of novel drug targets
Q37373139Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis
Q37433902Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution.
Q33894475Pilot study of large-scale production of mutant pigs by ENU mutagenesis
Q50645688Postnatal regulation of germ cells by activin: the establishment of the initial follicle pool.
Q34934319Preclinical models: status of basic research in depression
Q44002082Presence of visual head tracking differentiates normal sighted from retinal degenerate mice
Q24289028Progress in genetic studies of pain and analgesia
Q48515873Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes
Q33715878Propagation of an infertile hermaphrodite mouse lacking germ cells by using nuclear transfer and embryonic stem cell technology
Q30671070Protein--protein interaction maps: a lead towards cellular functions
Q31165060Quantification of brain maturation and growth patterns in C57BL/6J mice via computational neuroanatomy of diffusion tensor images
Q37087936Quiet as a mouse: dissecting the molecular and genetic basis of hearing
Q36732466RNA-seq-based mapping and candidate identification of mutations from forward genetic screens
Q47074000Radiographic analysis of zebrafish skeletal defects
Q35053230Random mutagenesis in the mouse as a tool in drug discovery
Q37174167Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease
Q37271710Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant
Q30487860Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study
Q40022642Removing the cloak of invisibility: phenotyping the mouse
Q35145877Rodent models of genetic disease
Q28513813Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance
Q33951133SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.
Q57197907Screen for alterations of iron related parameters in N-ethyl-N-nitrosourea-treated mice identified mutant lines with increased plasma ferritin levels
Q28505175Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models
Q44974504Screening for novel ENU-induced rhythm, entrainment and activity mutants.
Q38615493Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.
Q34446134Sensitized polygenic trait analysis
Q88345284Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer
Q34414535Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development.
Q28585371Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development
Q35650387Sleep, circadian rhythms, and interval timing: evolutionary strategies to time information
Q33784240Spatiotemporal maturation patterns of murine brain quantified by diffusion tensor MRI and deformation-based morphometry
Q48081611Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse.
Q36150477Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis.
Q89621682Studies on N-Ethyl-N-nitrosourea Mutagenesis in BALB/c Mice
Q33695715Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling
Q59052723Surviving a knockout blow
Q35172304TGFβ superfamily signaling regulators are differentially expressed in the developing and adult mouse testis
Q34426086Taking a functional genomics approach in molecular medicine
Q30050478Talking about a Revolution
Q34267418Target discovery
Q35074291Target discovery and validation in the post-genomic era.
Q44714383Target-selected mutagenesis of the rat.
Q35191481Technicolour transgenics: imaging tools for functional genomics in the mouse
Q33464903Tests to assess motor phenotype in mice: a user's guide
Q24644441The European dimension for the mouse genome mutagenesis program
Q57338416The G-netics of dark skin
Q30563766The Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenotyping data
Q38209454The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.
Q35043790The Notch ligand Jagged1 is required for inner ear sensory development.
Q26774070The Snark was a Boojum - reloaded
Q28592737The Zic2 gene directs the formation and function of node cilia to control cardiac situs
Q36160830The art and design of genetic screens: mouse
Q38841527The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media
Q28587608The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3
Q33388684The expanding role of mouse genetics for understanding human biology and disease
Q28591100The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development
Q21092858The mouse genetics toolkit: revealing function and mechanism
Q34522821The mouse: genetics meets behaviour
Q31039716The old and new face of craniofacial research: How animal models inform human craniofacial genetic and clinical data
Q74133551The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs
Q37429914The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function
Q36328456The robotic mouse: unravelling the function of AF4 in the cerebellum
Q36487730The role of mutagenesis in defining genes in behaviour
Q28281239The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
Q24806051The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis
Q36453343The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity.
Q36748513Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse
Q24671596Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene
Q92854134Time-Series Chlorophyll Fluorescence Imaging Reveals Dynamic Photosynthetic Fingerprints of sos Mutants to Drought Stress
Q36762503Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells
Q37478081Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling
Q40443093Training and aging modulate the loss-of-balance phenotype observed in a new ENU-induced allele of Otopetrin1.
Q34968783Transgenic and gene targeting studies of hair cell function in mouse inner ear.
Q34189469Transgenic gene knock-outs: functional genomics and therapeutic target selection
Q34608704Transgenic systems in drug discovery: from target identification to humanized mice
Q30679435Transposition and gene disruption in the male germline of the mouse
Q34618543Transposon Mutagenesis of the Mouse Germline
Q37264246Trends in large-scale mouse mutagenesis: from genetics to functional genomics
Q38351359Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation.
Q51725721Two new mouse chromosome 11 balancers.
Q50472958Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4.
Q50417403Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells
Q36488817Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse
Q21145261Understanding mammalian genetic systems: the challenge of phenotyping in the mouse
Q34726732Understanding the human condition: experimental strategies in mammalian genetics
Q37812277Unraveling the genetics of otitis media: from mouse to human and back again
Q34508473Unravelling novel intracellular pathways in cell-based assays
Q35607382Use of mouse genetics for studying inner ear development
Q37826464Use of mouse models in studying type 2 diabetes mellitus
Q55519023Using Drosophila to study mechanisms of hereditary hearing loss.
Q42941341Using ENU mutagenesis for phenotype-driven analysis of the mouse
Q34750310Using mouse models to dissect the genetics of obesity
Q81154549Vascular occlusion and thrombosis in zebrafish
Q34643112Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice
Q38115171What have we learned from murine models of otitis media?
Q44519043Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor
Q31139050Zebrafish: a genetic model for hemostasis and thrombosis.
Q48128104Zic2 is required for neural crest formation and hindbrain patterning during mouse development.
Q24545820l7Rn6 encodes a novel protein required for clara cell function in mouse lung development
Q39798860microMRI-HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos
Q34310668siRNAs: applications in functional genomics and potential as therapeutics

Search more.