| P2093 | author name string | Tong Li | |
| | Donald L Price | |
| | Philip C Wong | |
| | Guojun Ma | |
| P2860 | cites work | Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing | Q24290265 |
| | Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch | Q24307727 |
| | Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo | Q24315707 |
| | Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes | Q24532064 |
| | A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex | Q28185671 |
| | APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes | Q28216835 |
| | Identification of distinct gamma-secretase complexes with different APH-1 variants | Q28274942 |
| | Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency | Q28505078 |
| | Mice lacking both presenilin genes exhibit early embryonic patterning defects | Q28508946 |
| | Notch1 is required for the coordinate segmentation of somites | Q28513676 |
| | Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity | Q28592098 |
| | Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals | Q28610905 |
| | Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form | Q29619372 |
| | BACE1 is the major beta-secretase for generation of Abeta peptides by neurons | Q32063781 |
| | APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos | Q33894454 |
| | aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation | Q34137893 |
| | Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. | Q34194714 |
| | Intramembrane proteolysis: theme and variations. | Q34342964 |
| | gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? | Q34609917 |
| | γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 | Q34648460 |
| | Genetically engineered mouse models of neurodegenerative diseases | Q34708236 |
| | Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex | Q35105866 |
| | Mild cognitive impairment clinical trials | Q35194758 |
| | Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex | Q36381474 |
| | A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis | Q36690193 |
| | The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities | Q40559975 |
| | Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex | Q40620892 |
| | The role of presenilin cofactors in the gamma-secretase complex | Q40661006 |
| | Mutant genes in familial Alzheimer's disease and transgenic models | Q41733323 |
| | Reconstitution of gamma-secretase activity | Q44393107 |
| | Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain | Q44405189 |
| | Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates | Q44488079 |
| | Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin | Q44511126 |
| | The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex | Q44548884 |
| | Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. | Q45345845 |
| | Notch1 is essential for postimplantation development in mice. | Q52512097 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Nicastrin | Q14911609 |
| | Aph1 homolog C, gamma secretase subunit | Q21432647 |
| | Aph1 homolog A, gamma secretase subunit | Q21496069 |
| | Aph1 homolog B, gamma secretase subunit | Q21496070 |
| | Presenilin 1 | Q21496912 |
| P304 | page(s) | 192-198 | |
| P577 | publication date | 2005-01-01 | |
| P1433 | published in | Journal of Neuroscience | Q1709864 |
| P1476 | title | APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development | |
| P478 | volume | 25 | |