| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | C. T. Esmon | |
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 4743–4746 | |
| P577 | publication date | 1989-03-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The roles of protein C and thrombomodulin in the regulation of blood coagulation | |
| P478 | volume | 264 |
| Q46599341 | A Mathematical Model of Venous Thrombosis Initiation |
| Q36712188 | A biologically active surface enzyme assembly that attenuates thrombus formation. |
| Q74403155 | A comparative double-blind randomized trial of activated protein C and unfractionated heparin in the treatment of disseminated intravascular coagulation |
| Q92878177 | A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish |
| Q37431399 | ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor |
| Q37588568 | Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged |
| Q40342837 | Acceleration of the thrombin inactivation of single chain urokinase-type plasminogen activator (pro-urokinase) by thrombomodulin |
| Q50291227 | Activated protein C cleaves factor Va to factor Vi intermediate form |
| Q50291223 | Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C |
| Q41043951 | Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor |
| Q93198106 | Acute Portal Vein Thrombosis Treated with Recombinant Human Soluble Thrombomodulin Combined with Antithrombin III |
| Q35661794 | Advanced glycation end products (AGEs) on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the vasculature: a link between surface-associated AGEs and diabetic complications |
| Q34225836 | An acquired antithrombin autoantibody directed toward the catalytic center of the enzyme |
| Q34172057 | An allosteric switch controls the procoagulant and anticoagulant activities of thrombin |
| Q36674553 | Antibody SPC-54 provides acute in vivo blockage of the murine protein C system. |
| Q40506562 | Antiphospholipid antibodies and the antiphospholipid syndrome |
| Q43506162 | Atomic structures of two nitroxide spin labels complexed with human thrombin: comparison with solution studies |
| Q37388336 | Basic mechanisms and pathogenesis of venous thrombosis |
| Q24794692 | Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis |
| Q47901692 | Binding of anticardiolipin antibodies to protein C via beta2-glycoprotein I (beta2-GPI): a possible mechanism in the inhibitory effect of antiphospholipid antibodies on the protein C system |
| Q36778167 | Bio-inspired liposomal thrombomodulin conjugate through bio-orthogonal chemistry. |
| Q35649582 | Blood clot formation under flow: the importance of factor XI depends strongly on platelet count |
| Q36008712 | Characterization of the threshold response of initiation of blood clotting to stimulus patch size |
| Q42984646 | Cleavage of the thrombin receptor: identification of potential activators and inactivators |
| Q35775912 | Coagulation in sepsis |
| Q28469258 | Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies |
| Q42586557 | Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting". |
| Q41911660 | Constitutive repression of interleukin-1alpha in endothelial cells |
| Q34041148 | Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site |
| Q40910756 | Cytokines and proteoglycans |
| Q34803633 | Differential regulation of endothelial cell activation by complement and interleukin 1alpha |
| Q57293851 | Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies |
| Q37142684 | Dissociation of activated protein C functions by elimination of protein S cofactor enhancement |
| Q35878956 | Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect |
| Q36880146 | Dynamic shear stress regulation of inflammatory and thrombotic pathways in baboon endothelial outgrowth cells |
| Q47947885 | Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients |
| Q42160901 | Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin |
| Q24599265 | Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease |
| Q35753295 | Extrahepatic expression and regulation of protein C in the mouse |
| Q24563608 | Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C |
| Q35039847 | Fibrinolysis and the control of blood coagulation |
| Q34648558 | Flow-mediated endothelial mechanotransduction |
| Q42104389 | Functional role of the polysaccharide component of rabbit thrombomodulin proteoglycan. Effects on inactivation of thrombin by antithrombin, cleavage of fibrinogen by thrombin and thrombin-catalysed activation of factor V. |
| Q35248863 | Genomic profiling of host responses to Lassa virus: therapeutic potential from primate to man |
| Q37582778 | Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin |
| Q40851193 | Glycosaminoglycans and the regulation of blood coagulation |
| Q35001179 | Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis |
| Q41834727 | Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol est |
| Q36133849 | Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig. |
| Q37040260 | Hypercoagulable State |
| Q38302763 | Identification of a region in protein C involved in thrombomodulin-stimulated activation by thrombin: potential repulsion at anion-binding site I in thrombin |
| Q24528162 | Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474 |
| Q37640471 | Immobilization of actively thromboresistant assemblies on sterile blood-contacting surfaces |
| Q57822378 | In silico thrombin generation: Plasma composition imbalance and mortality in human immunodeficiency virus |
| Q71986301 | Inefficient processing of human protein C in the mouse mammary gland |
| Q41205363 | Inherited defects of the protein C anticoagulant system in childhood thrombo-embolism |
| Q35047092 | Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V. |
| Q34213851 | Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine |
| Q92923746 | Innovative Three-Step Microwave-Promoted Synthesis of N-Propargyltetrahydroquinoline and 1,2,3-Triazole Derivatives as a Potential Factor Xa (FXa) Inhibitors: Drug Design, Synthesis, and Biological Evaluation |
| Q41888977 | Interaction of activated protein C with serpins |
| Q35885818 | Interactions between the innate immune and blood coagulation systems |
| Q36049897 | Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold |
| Q28579306 | Localization of thrombomodulin in pericryptal fibroblasts of the rat duodenum |
| Q96132907 | Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals |
| Q41019872 | Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency |
| Q34174481 | Modeling zymogen protein C. |
| Q36278723 | Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen |
| Q82083962 | Multi-chamber intracardiac thrombi associated with activated protein C resistance in a patient with dilated cardiomyopathy |
| Q24681351 | New anticoagulants for the prevention and treatment of venous thromboembolism |
| Q36042279 | New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin |
| Q40774985 | New biological concepts on coagulation inhibitors |
| Q34809827 | New mechanisms for vascular control of inflammation mediated by natural anticoagulant proteins |
| Q40463597 | Novel Antithrombotic Drugs in Development |
| Q38129719 | Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond |
| Q39468892 | Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model |
| Q90686395 | Plasma From Patients Undergoing Liver Transplantation Is Resistant to Anticoagulant Activity of Soluble Thrombomodulin |
| Q41752338 | Polymeric coatings that mimic the endothelium: combining nitric oxide release with surface-bound active thrombomodulin and heparin |
| Q51814110 | Production of an active recombinant thrombomodulin derivative in transgenic tobacco plants and suspension cells. |
| Q37853216 | Proteases as therapeutics |
| Q24564885 | Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system |
| Q58957239 | Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia |
| Q34479961 | Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor |
| Q33776220 | Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin |
| Q71377364 | Purpura fulminans in severe congenital protein C deficiency: monitoring of treatment with protein C concentrate |
| Q37367046 | Quantitative Systems Pharmacology Model to Predict the Effects of Commonly Used Anticoagulants on the Human Coagulation Network |
| Q33789809 | Recombinant Thrombomodulin Exerts Anti-autophagic Action in Endothelial Cells and Provides Anti-atherosclerosis Effect in Apolipoprotein E Deficient Mice |
| Q41240571 | Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin |
| Q41845471 | Recombinant human thrombomodulin. Regulation of cofactor activity and anticoagulant function by a glycosaminoglycan side chain |
| Q28195391 | Recurrent acute stent thrombosis associated with protein C and S deficiencies |
| Q37086949 | Reduced thrombin generation increases host susceptibility to group A streptococcal infection |
| Q35655441 | Regulatory functions of the coronary endothelium |
| Q42161739 | Retinoic acid stimulates expression of thrombomodulin, a cell surface anticoagulant glycoprotein, on human endothelial cells. Differences between up-regulation of thrombomodulin by retinoic acid and cyclic AMP |
| Q42920423 | Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities |
| Q34469113 | Role of human recombinant activated protein C and low dose corticosteroid therapy in sepsis |
| Q42796704 | Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin. |
| Q32060283 | Screening the molecular surface of human anticoagulant protein C: a search for interaction sites |
| Q35647766 | Sepsis and disseminated intravascular coagulation |
| Q41977575 | Serological tests for diagnosis and staging of hand-arm vibration syndrome (HAVS). |
| Q37290652 | Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications |
| Q64964975 | Strategies to avoid empiric blood product administration in liver transplant surgery. |
| Q36279670 | Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin |
| Q36176026 | Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis |
| Q41913676 | Successful treatment of rheumatoid arthritis is associated with a reduction in serum sE-selectin and thrombomodulin level |
| Q33336176 | Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition |
| Q42845204 | Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic |
| Q30475849 | Targeted delivery of therapeutics to endothelium |
| Q28236023 | Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects |
| Q27734660 | The 2.8 A crystal structure of Gla-domainless activated protein C |
| Q35674094 | The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin |
| Q33743664 | The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism |
| Q68055872 | The clinical importance of protein C and S deficiency for surgical patients |
| Q36280463 | The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding |
| Q89980561 | The efficacy of recombinant human soluble thrombomodulin (rhsTM) treatment for acute exacerbation of idiopathic pulmonary fibrosis: a systematic review and meta-analysis |
| Q42844019 | The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin |
| Q42796533 | The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-thrombin |
| Q24310383 | The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade |
| Q36229803 | The prothrombotic phenotypes in familial protein C deficiency are differentiated by computational modeling of thrombin generation |
| Q35927779 | The role of thrombomodulin lectin-like domain in inflammation |
| Q42619428 | The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin |
| Q34360277 | The tissue factor requirement in blood coagulation |
| Q34016899 | Theory of allosteric effects in serine proteases. |
| Q41845737 | Thrombin-binding affinities of different disulfide-bonded isomers of the fifth EGF-like domain of thrombomodulin |
| Q42160496 | Thrombin-thrombomodulin interaction: energetics and potential role of water as an allosteric effector |
| Q36101033 | Thrombomodulin Influences the Survival of Patients with Non-Metastatic Colorectal Cancer through Epithelial-To-Mesenchymal Transition (EMT). |
| Q34141536 | Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation |
| Q36614638 | Thrombomodulin expression in colorectal carcinoma is protective and correlates with survival |
| Q53705588 | Thrombomodulin in intensive care patients. |
| Q35010955 | Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism |
| Q47947313 | Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial-mesenchymal transition biomarkers |
| Q39114905 | Thrombomodulin mediates the progression of epithelial ovarian cancer cells |
| Q37379943 | Thrombomodulin modulates growth of tumor cells independent of its anticoagulant activity |
| Q34999818 | Transcriptome analysis of human peripheral blood mononuclear cells exposed to Lassa virus and to the attenuated Mopeia/Lassa reassortant 29 (ML29), a vaccine candidate |
| Q91768594 | Transferrin plays a central role in coagulation balance by interacting with clotting factors |
| Q42161888 | Up-regulation of thrombomodulin by activation of histamine H1-receptors in human umbilical-vein endothelial cells in vitro |
| Q39061982 | Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor |
| Q86413121 | Victims of lethal hypothermia have decreased levels of thrombomodulin in myocardium and urine |
| Q34724999 | Vitamin K-dependent protein S in Leydig cells of human testis |
| Q36597746 | Vitronectin receptor: tissue specific expression or adaptation to culture? |
| Q75356546 | [Role of the innate immune response in sepsis] |
| Q50291220 | activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin |
| Q40148359 | von Willebrand factor release and thrombomodulin and tissue factor expression in Rickettsia conorii-infected endothelial cells. |
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