review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Eric Oldfield | |
Xinxin Feng | |||
P2860 | cites work | Chemotherapy for second-stage Human African trypanosomiasis | Q24201785 |
Ancient Chinese anti-fever cure becomes panacea for malaria | Q24642245 | ||
Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity | Q24646340 | ||
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence | Q24650591 | ||
Shifting from the single to the multitarget paradigm in drug discovery | Q27144242 | ||
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases | Q27645000 | ||
Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation | Q27654261 | ||
Applying Molecular Dynamics Simulations to Identify Rarely Sampled Ligand-bound Conformational States of Undecaprenyl Pyrophosphate Synthase, an Antibacterial Target | Q27666848 | ||
Antibacterial drug leads targeting isoprenoid biosynthesis | Q27675524 | ||
Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics | Q27676950 | ||
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity | Q27677853 | ||
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis | Q27679484 | ||
Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis | Q27681516 | ||
Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c | Q27681663 | ||
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 | Q27860791 | ||
Antibacterial effect of human V gamma 2V delta 2 T cells in vivo | Q28363497 | ||
Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates | Q28535348 | ||
Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs | Q57188906 | ||
Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis | Q73062260 | ||
Antibiotics: a shot in the arm | Q80889978 | ||
Antibiotics at the crossroads | Q80889994 | ||
Targeting virulence: can we make evolution-proof drugs? | Q87435859 | ||
Drugs for bad bugs: confronting the challenges of antibacterial discovery | Q29547723 | ||
Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis. | Q31149060 | ||
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines | Q33223601 | ||
Challenges of antibacterial discovery | Q33793074 | ||
Multitarget drug discovery for tuberculosis and other infectious diseases | Q33854785 | ||
Parasitic loads in tissues of mice infected with Trypanosoma cruzi and treated with AmBisome | Q33955428 | ||
Transferable vancomycin resistance in a community-associated MRSA lineage | Q33956707 | ||
Amphotericin B: spectrum and resistance | Q34110285 | ||
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine | Q34223139 | ||
The composition of Ehrlich's salvarsan: resolution of a century-old debate | Q34380428 | ||
Metabolic engineering of Salmonella vaccine bacteria to boost human Vγ2Vδ2 T cell immunity. | Q34560345 | ||
Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. | Q35044119 | ||
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis | Q35867500 | ||
Multi-targeting by monotherapeutic antibacterials. | Q36679193 | ||
Farnesyl diphosphate synthase inhibitors from in silico screening | Q36899690 | ||
Membrane lipid homeostasis in bacteria | Q37080837 | ||
From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway | Q37326534 | ||
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs | Q37579799 | ||
The emerging role of amiodarone and dronedarone in Chagas disease | Q38032507 | ||
Multitarget ligands in antibacterial research: progress and opportunities | Q38068475 | ||
Viable screening targets related to the bacterial cell wall. | Q38070780 | ||
Ribosome-targeting antibiotics and mechanisms of bacterial resistance. | Q38171225 | ||
Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties | Q38326809 | ||
Pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica: molecular cloning, recombinant expression and inhibition by pyrophosphate analogues | Q38357749 | ||
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside | Q39321531 | ||
Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators | Q39758159 | ||
Concurrent Chagas' disease and borderline disseminated cutaneous leishmaniasis: The role of amiodarone as an antitrypanosomatidae drug | Q41360414 | ||
Statins enhance formation of phagocyte extracellular traps | Q41426439 | ||
Antibiotic effectiveness: balancing conservation against innovation | Q41741779 | ||
Antibiotic resistance: An infectious arms race. | Q42217180 | ||
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy | Q43574122 | ||
Characterization of a novel, broad-based fungicidal activity for the antiarrhythmic drug amiodarone | Q43830145 | ||
Antifungal Activity of Amiodarone Is Mediated by Disruption of Calcium Homeostasis | Q44445840 | ||
Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas' disease. | Q46006642 | ||
Orally active squalene synthase inhibitors: bis((acyloxy)alkyl) prodrugs of the alpha-phosphonosulfonic acid moiety | Q46641730 | ||
Pentamidine is an uncoupler of oxidative phosphorylation in rat liver mitochondria | Q46899992 | ||
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole | Q46922516 | ||
Mycobacteria possess a surprisingly small number of ribosomal RNA genes in relation to the size of their genome | Q47208727 | ||
Additivity of molecular fields: CoMFA study on dual activators of PPARalpha and PPARgamma | Q48006778 | ||
An audience with...John Reed | Q48375310 | ||
Resistance to polyene antibiotics and correlated sterol changes in two isolates of Candida tropicalis from a patient with an amphotericin B-resistant funguria. | Q53743852 | ||
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | antibiotic resistance | Q380775 |
P304 | page(s) | 664-74 | |
P577 | publication date | 2014-12-01 | |
P1433 | published in | Trends in Pharmacological Sciences | Q2451474 |
P1476 | title | Resistance-resistant antibiotics | |
P478 | volume | 35 |
Q39175852 | A Critical Review of Analytical Methods for Quantification of Cefotaxime. |
Q91645862 | A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles |
Q49912940 | A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK. |
Q37637620 | A stepwise introduction of a successful antimicrobial stewardship program. Experience from a tertiary care university hospital in Western, Saudi Arabia |
Q35886164 | Antibacterial drug leads: DNA and enzyme multitargeting |
Q38380313 | Antibacterial synergic effect of honey from two stingless bees: Scaptotrigona bipunctata Lepeletier, 1836, and S. postica Latreille, 1807. |
Q36419761 | Antiinfectives targeting enzymes and the proton motive force. |
Q26752527 | Antimicrobial Drugs in Fighting against Antimicrobial Resistance |
Q92178633 | Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine |
Q27727743 | Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase |
Q28822179 | Endless Resistance. Endless Antibiotics? |
Q53686599 | Failure of daptomycin to kill Staphylococcus aureus: impact of bacterial membrane fatty acid composition. |
Q35963318 | In Vitro and in Vivo Activity of Multitarget Inhibitors against Trypanosoma brucei |
Q42351008 | Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth. |
Q92682023 | Ligands and Receptors with Broad Binding Capabilities Have Common Structural Characteristics: An Antibiotic Design Perspective |
Q30385391 | Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. |
Q28276967 | Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action |
Q52655075 | Novel Staphyloxanthin Inhibitors with Improved Potency against Multidrug Resistant Staphylococcus aureus. |
Q26747572 | One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug |
Q59128929 | PLGA/Nano-ZnO Composite Particles for Use in Biomedical Applications: Preparation, Characterization, and Antimicrobial Activity |
Q39039936 | Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections. |
Q38778154 | Research and development of antibiotics: insights from patents and citation network. |
Q38755043 | Resisting resistance: is there a solution for malaria? |
Q40072185 | Spontaneous mutation rate is a plastic trait associated with population density across domains of life |
Q92604028 | Staphyloxanthin: a potential target for antivirulence therapy |
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