Heat shock proteins--modulators of apoptosis in tumour cells

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Heat shock proteins--modulators of apoptosis in tumour cells is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1046461154
P356DOI10.1038/SJ.LEU.2401841
P3181OpenCitations bibliographic resource ID1391761
P698PubMed publication ID10914538
P5875ResearchGate publication ID12404434

P50authorThomas G CotterQ61258687
P2093author name stringD Sheehan
E M Creagh
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cellsQ22009395
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9Q22009407
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathwaysQ24309037
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
BAG-1 modulates the chaperone activity of Hsp70/Hsc70.Q24313113
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3Q24324482
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell deathQ24336389
The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosisQ24532811
Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosisQ24534085
Mitochondrial release of caspase-2 and -9 during the apoptotic processQ24676806
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agentQ27736012
HSP104 required for induced thermotoleranceQ27931727
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1Q28118304
Caspase-mediated activation of PAK2 during apoptosis: proteolytic kinase activation as a general mechanism of apoptotic signal transduction?Q28141412
Apoptosis in the pathogenesis and treatment of diseaseQ28235731
Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock proteinQ28237289
From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance stateQ28280396
Death receptors: signaling and modulationQ28280897
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complexQ28283294
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor familyQ28285445
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosisQ28292299
In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodiesQ28378006
Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathwayQ28379145
Bax directly induces release of cytochrome c from isolated mitochondriaQ28588847
Heat shock gene regulation by nascent polypeptides and denatured proteins: hsp70 as a potential autoregulatory factorQ28609629
Caspases: enemies withinQ29547315
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
Mitochondria and apoptosisQ29547905
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosisQ29616513
The heat-shock proteinsQ29617227
Cell death: the significance of apoptosisQ29617620
The Bcl-2 protein family: arbiters of cell survivalQ29618158
The ubiquitin-proteasome proteolytic pathwayQ29618638
The heat-shock responseQ29619473
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathQ29620000
Hsp90 chaperones protein folding in vitro.Q30351360
The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by hsp70.Q30422116
Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.Q33543957
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell deathQ33669499
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.Q33887952
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.Q33889765
Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.Q34094129
Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffsQ34204429
Apoptotic cell death induced by c-myc is inhibited by bcl-2.Q34255589
The mitochondrial death/life regulator in apoptosis and necrosisQ34465435
BCL-2 family: regulators of cell deathQ34468840
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.Q34532399
Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overviewQ35370212
Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and diseaseQ35531445
Heat-shock proteins and stress tolerance in microorganismsQ35568753
Modulation of cell death by Bcl-XL through caspase interactionQ35739439
Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells.Q35785944
The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signalingQ36255096
Heat shock proteins increase resistance to apoptosis.Q41226590
Fas receptor (CD95)-mediated apoptosis in leukemic cellsQ41454998
The role of the hsp90-based chaperone system in signal transduction by nuclear receptors and receptors signaling via MAP kinaseQ41455758
Butyrate induced apoptosis in lymphoid cells preceded by transient over-expression of HSP70 mRNA.Q41494758
Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protectionQ41581973
Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemiaQ41740875
Oxygen radicals and signalingQ41750986
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosisQ41878142
p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.Q42125448
Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cellsQ42466019
Oxidized low density lipoproteins elicit DNA fragmentation of cultured lymphoblastoid cellsQ43983627
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytesQ44192187
Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly.Q45950874
Bcl-2 family proteinsQ46508339
The Hsp90 complex--a super-chaperone machine as a novel drug targetQ47280893
Heat shock protein 72 modulates pathways of stress-induced apoptosis.Q47921342
Differentiation lineage-specific expression of human heat shock transcription factor 2.Q51090080
RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis.Q52261755
The RNA polymerase II molecule at the 5' end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged.Q52459657
The 5' ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I.Q52526056
Modulation of mitochondrial Ca(2+) homeostasis by Bcl-2.Q52536986
Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.Q52548229
HSP27 inhibits cytochrome c-dependent activation of procaspase-9.Q54073678
Signaling defect in the activation of caspase-3 and PKCdelta in human TUR leukemia cells is associated with resistance to apoptosis.Q54103551
Antileukemic action of buthionine sulfoximine: evidence for an intrinsic death mechanism based on oxidative stress.Q54122167
Constitutive expression of heat-shock protein 70 in mammalian cells confers thermoresistanceQ54293839
Enhanced constitutive expression of the 27-kDa heat shock proteins in heat-resistant variants from Chinese hamster cells.Q54375768
Monoclonal antibody-mediated tumor regression by induction of apoptosis.Q55059937
A new puffing pattern induced by temperature shock and DNP in drosophilaQ55918906
MULTIDRUG RESISTANCE IN LEUKAEMIAQ57650127
Antioxidant-mediated inhibition of the heat shock response leads to apoptosisQ59416716
Heat Shock Protein 70 Inhibits Caspase-Dependent and -Independent Apoptosis in Jurkat T CellsQ62082005
Selective protection by hsp 70 against cytotoxic drug-, but not Fas-induced T-cell apoptosisQ62082010
Oxidative Damage to Behavior During AgingQ68327453
Overlapping phenotypes of multidrug resistance among panels of human cancer-cell linesQ70913846
Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibodyQ71143207
Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cellsQ71167543
Susceptibility of AML cells to in vitro apoptosis correlates with heat shock protein 70 (hsp 70) expressionQ71248571
Translational efficiency of heat-induced messages in Drosophila melanogaster cellsQ71501483
Oxygen radicals induce stress proteins and tolerance to oxidative stress in human lymphocytesQ71518329
No requirement of reactive oxygen intermediates in Fas‐mediated apoptosisQ71645998
Temporal relationships between stress protein induction, progesterone withdrawal, and apoptosis in corpora lutea of ewes treated with prostaglandin F2αQ72054711
Analysis of heat-shock protein expression in myeloid leukaemia cells by flow cytometryQ72326973
Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cellsQ72611142
Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotoleranceQ73500626
Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patientsQ73685077
Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expressionQ74392830
Proteases to die forQ74630246
Metabolic oxidative stress-induced HSP70 gene expression is mediated through SAPK pathway. Role of Bcl-2 and c-Jun NH2-terminal kinaseQ77478119
Caspase-independent cell killing by Fas-associated protein with death domainQ36256374
E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmkQ36274864
Mitochondrial control of nuclear apoptosis.Q36366491
Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.Q36367105
Bcl-2 inhibits the mitochondrial release of an apoptogenic proteaseQ36367392
CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cellsQ36526710
A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock proteinQ36530055
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosisQ36571858
Lethal effect of the anti-Fas antibody in miceQ36696599
Dynamic changes in the structure and intracellular locale of the mammalian low-molecular-weight heat shock proteinQ36849793
Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domainQ36876655
Heat shock, stress proteins, chaperones, and proteotoxicityQ37190844
Is hsp70 the cellular thermometer?Q37260519
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.Q37402942
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteinsQ37404795
Mitochondria are selective targets for the protective effects of heat shock against oxidative injuryQ37523837
Oxidative stress in mitochondria: its relationship to cellular Ca2+ homeostasis, cell death, proliferation, and differentiationQ37617336
Reactive oxygen species play an important role in the activation of heat shock factor 1 in ischemic-reperfused heartQ38327825
Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapyQ39995848
Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteinsQ40346246
Apoptosis and its role in human diseaseQ40534415
Hsp70--a multi-gene, multi-structure, multi-function family with potential clinical applicationsQ40648806
Molecular chaperone functions of heat-shock proteinsQ40711828
Oxidative stress as a mediator of apoptosisQ40729167
Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1.Q40806764
Cellular defenses against damage from reactive oxygen speciesQ40808542
Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine releaseQ41010028
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signalsQ41050794
Bcl-xL overexpression restricts heat-induced apoptosis and influences hsp70, bcl-2, and Bax protein levels in FL5.12 cellsQ41066632
Conversion of Bcl-2 to a Bax-like death effector by caspasesQ41073693
Bcl-2 and Hsp27 act at different levels to suppress programmed cell deathQ41099190
Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell lineQ41111745
Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responsesQ41112902
Role of peroxide and superoxide anion during tumour cell apoptosisQ41121455
Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue BakQ41134694
Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activityQ41139893
On the mechanism of action of H2O2 in the cellular stressQ41163477
Reactive oxygen intermediate(s) (ROI): common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosisQ41169101
Inhibition of HSP70 expression by calcium ionophore A23187 in human cells. An effect independent of the acquisition of DNA-binding activity by the heat shock transcription factor.Q41186088
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosisQ41204766
P433issue7
P921main subjectapoptotic processQ14599311
P304page(s)1161-1173
P577publication date2000-07-01
P1433published inLeukemiaQ6534498
P1476titleHeat shock proteins--modulators of apoptosis in tumour cells
P478volume14

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