Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38

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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38 is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0898-6568(01)00148-6
P3181OpenCitations bibliographic resource ID1841302
P698PubMed publication ID11369511

P2093author name stringS. J. Harper
P. LoGrasso
P2860cites workThe JIP group of mitogen-activated protein kinase scaffold proteinsQ22010547
Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neuronsQ22010849
Signal transduction by tumor necrosis factor mediated by JNK protein kinasesQ24308037
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domainQ24308838
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinaseQ24309889
p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous systemQ24310112
A protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2Q24313872
Selective interaction of JNK protein kinase isoforms with transcription factorsQ24317346
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)Q24321919
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)Q24336966
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2Q24532154
ATF-2 contains a phosphorylation-dependent transcriptional activation domainQ24568315
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factorQ24648537
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathwayQ24650627
A splicing variant of a death domain protein that is regulated by a mitogen-activated kinase is a substrate for c-Jun N-terminal kinase in the human central nervous systemQ24681222
Crystal structure of JNK3: a kinase implicated in neuronal apoptosisQ27765333
Neurotrophin signal transduction in the nervous systemQ27876223
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylationQ28139447
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivoQ28238990
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylationQ28243308
Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38Q28249893
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathwayQ28255002
JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinasesQ28256056
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP KinaseQ28280649
A mammalian scaffold complex that selectively mediates MAP kinase activationQ28281953
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonineQ28287650
Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cellsQ28343994
JNK is required for effector T-cell function but not for T-cell activationQ28507174
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 geneQ28507982
Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brainQ28571844
Differential expression of SAPK isoforms in the rat brain. An in situ hybridisation study in the adult rat brain and during post-natal developmentQ28575489
c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusionQ28576960
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Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neuronsQ28590132
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesisQ28593865
Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38deltaQ28646538
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6Q28678886
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
Cellular survival: a play in three AktsQ29547806
Regulation of neuronal survival by the serine-threonine protein kinase AktQ29614185
The stress-activated protein kinase subfamily of c-Jun kinasesQ29620001
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1Q29620495
Up-regulation of genes involved in cellular stress and apoptosis in a rat model of hippocampal degenerationQ30835083
The p38 signal transduction pathway: activation and functionQ33838955
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.Q48287496
Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigraQ48292836
PACAP protects hippocampal neurons against apoptosis: involvement of JNK/SAPK signaling pathwayQ48295219
Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neuronsQ48312815
JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous systemQ33887876
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.Q33893183
Identification and characterization of a predominant isoform of human MKK3.Q34416895
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammationQ34419537
p38-2, a novel mitogen-activated protein kinase with distinct properties.Q34433633
MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinaseQ34457998
Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons.Q34462515
Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activityQ36074411
Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosisQ36235038
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinasesQ36667357
MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.Q36884483
Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia In vivo.Q37019949
Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylationQ39631004
Molecular determinants that mediate selective activation of p38 MAP kinase isoformsQ40387373
Early events in neurotrophin signalling via Trk and p75 receptorsQ40957968
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6Q41079070
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinaseQ41091097
p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptorsQ42071377
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neuronsQ42181592
Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivativesQ42439874
Role of the Jun kinase pathway in the regulation of c-Jun expression and apoptosis in sympathetic neurons.Q42450734
Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis.Q42466285
Chronic sparing of delayed alternation performance and choline acetyltransferase activity by CEP-1347/KT-7515 in rats with lesions of nucleus basalis magnocellularisQ42466288
Activity and expression of JNK1, p38 and ERK kinases, c-Jun N-terminal phosphorylation, and c-jun promoter binding in the adult rat brain following kainate-induced seizuresQ42473299
Colocalisation and covariation of c-JUN transcription factor with galanin in primary afferent neurons and with CGRP in spinal motoneurons following transection of rat sciatic nerveQ42482823
A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.Q42536958
Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cellsQ42539781
Opposite functions of jun-B and c-jun in growth regulation and neuronal differentiationQ42813493
Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.Q42828653
Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit.Q42833278
Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survivalQ42911158
Neurotrophic molecules: strategies for designing effective therapeutic molecules in neurodegenerationQ45890180
The primary structure of p38 gamma: a new member of p38 group of MAP kinasesQ46763189
Apoptosis of cerebellar granule cells induced by serum withdrawal, glutamate or beta-amyloid, is independent of Jun kinase or p38 mitogen activated protein kinase activation.Q47719854
CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.Q47959232
Progress toward understanding the molecular mechanisms of neurotrophic factor signallingQ48026353
Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I.Q48034415
Inhibitors of mitogen-activated protein kinases protect axotomized developing neuronsQ48087861
Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neuronsQ48144694
An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neuronsQ48219466
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain developmentQ48219557
p38 kinase is activated in the Alzheimer's disease brainQ48227440
Human c-Jun N-terminal kinase expression and activation in the nervous systemQ48249466
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?Q48277117
Axotomy-induced c-JUN expression in young medial septal neurons is regulated by nerve growth factorQ48382326
Activation of p38MAPK in microglia after ischemia.Q48497493
Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons.Q48548127
Localization of the messenger RNA for the c-Jun NH2-terminal kinase kinase in the adult and developing rat brain: an in situ hybridization studyQ48633600
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cellsQ48656057
Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons.Q48707018
Medial septal cholinergic neurons express c-Jun but do not undergo DNA fragmentation after fornix-fimbria transectionsQ48826522
Selective expression of the immediate early gene c-jun in axotomized rat medial septal neurons is not related to neuronal degeneration.Q49085222
Transection of rat fimbria-fornix induces lasting expression of c-Jun protein in axotomized septal neurons immunonegative for choline acetyltransferase and nitric oxide synthase.Q50760566
Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones.Q51101721
Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.Q52177288
Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathwayQ57042606
Integration of MAP kinase signal transduction pathways at the serum response elementQ58415341
The anti-apoptotic protein ITA is essential for NGF-mediated survival of embryonic chick neuronsQ60215412
Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathyQ60227864
Differential transcription and translation of immediate early genes in the gerbil hippocampus after transient global ischemiaQ70501469
Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neuronsQ71070351
Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survivalQ71246241
Inhibition of p42 and p44 mitogen-activated protein kinase activity by PD98059 does not suppress nerve growth factor-induced survival of sympathetic neuronesQ71667558
Aberrant stress-induced phosphorylation of perikaryal neurofilamentsQ71825265
A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell deathQ72232625
Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMPQ72254074
Differential regulation of c-JUN expression in rat retinal ganglion cells after proximal and distal optic nerve transectionQ72396757
Expression of c-Jun as a response to dorsal root and peripheral nerve section in damaged and adjacent intact primary sensory neurons in the ratQ72657041
Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neuronsQ72903790
p38 map kinase substrate specificity differs greatly for protein and peptide substratesQ73165790
Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylationQ73226384
Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemiaQ73226725
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neuronsQ73278662
Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell linesQ73387849
Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell deathQ73531785
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinaseQ73575389
Kinetic mechanism for p38 MAP kinaseQ73611887
Apoptosis and impaired axonal regeneration of sensory neurons after nerve crush in diabetic ratsQ73658201
Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the ratQ73800967
Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neuronsQ73812100
Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathwayQ73977274
CEP-1347 increases ChAT activity in culture and promotes cholinergic neurone survival following fimbria-fornix lesionQ74102463
Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitorsQ74384001
Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitroQ74555031
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitroQ77796005
The inhibitors of apoptosis (IAPs) and their emerging role in cancerQ77900361
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinaseQ77906539
Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2Q78208149
P433issue5
P304page(s)299–310
P577publication date2001-05-01
P1433published inCellular SignallingQ1524097
P1476titleSignalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38
P478volume13