Roflumilast-N-oxide induces surfactant protein expression in human alveolar epithelial cells type II

scientific article (publication date: 2012)

Roflumilast-N-oxide induces surfactant protein expression in human alveolar epithelial cells type II is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...738369H
P356DOI10.1371/JOURNAL.PONE.0038369
P932PMC publication ID3398032
P698PubMed publication ID22815690
P5875ResearchGate publication ID229427692

P50authorStephan J SchliessmannQ82568152
Joachim Müller-QuernheimQ47008767
P2093author name stringGernot Zissel
Andreas Kirschbaum
Hermann Tenor
Till Plönes
Kerstin Höhne
P2860cites workAltered surfactant protein-A expression in type II pneumocytes in COPDQ84535537
Regulation of surfactant proteins by LPS and proinflammatory cytokines in fetal and newborn lung.Q51725053
Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edemaQ60364456
Transkriptionelle Aktivität der Surfactant-Apoproteine A1 und A2 in nicht kleinzelligen Bronchialkarzinomen und tumorfreien LungengewebenQ62632098
Prostaglandins regulate surfactant protein A (SP-A) gene expression in human fetal lung in vitroQ68473153
Surfactant protein-A concentration in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosisQ70558495
Pulmonary surfactant protein A: a serum marker of pulmonary fibrosis in patients with collagen vascular diseasesQ70840310
Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterizationQ72081556
Human SP-A1 and SP-A2 genes are differentially regulated during development and by cAMP and glucocorticoidsQ72411044
An improved assay of cyclic 3',5'-nucleotide phosphodiesterases with QAE-Sephadex columnsQ72854106
Transforming growth factor-beta(1) regulation of surfactant protein B gene expression is mediated by protein kinase-dependent intracellular translocation of thyroid transcription factor-1 and hepatocyte nuclear factor 3Q72999267
Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)Q73923679
Dose-proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitorQ79456145
Effects of ageing and smoking on SP-A and SP-D levels in bronchoalveolar lavage fluidQ81079509
Novel, non-radioactive, simple and multiplex PCR-cRFLP methods for genotyping human SP-A and SP-D marker allelesQ21343036
Characterization of a second human pulmonary surfactant-associated protein SP-A geneQ28186207
Function of surfactant proteins B and CQ28200193
Alveolar surfactant homeostasis and the pathogenesis of pulmonary diseaseQ28261260
Surfactant protein C: hormonal control of SP-C mRNA levels in vitroQ28579078
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrixQ29619797
Organization of the human SP-A and SP-D loci at 10q22-q23. Physical and radiation hybrid mapping reveal gene order and orientationQ32104427
Regulated gene expression in cultured type II cells of adult human lungQ33994671
Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genesQ34340858
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosisQ35087744
Surfactant dysfunctionQ35446540
Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitroQ35684878
Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitroQ35855331
Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitorsQ35933128
Surfactant protein C biosynthesis and its emerging role in conformational lung diseaseQ36041099
Phosphodiesterase inhibitors.Q36364429
Pulmonary collectins in innate immunity of the lungQ36816178
Genetic disorders of surfactant proteinsQ36851883
Thyroid transcription factor-1 (TTF-1/Nkx2.1/TITF1) gene regulation in the lungQ37336056
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD.Q37778289
Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzymeQ37972748
Extracellular nucleotides induce COX-2 up-regulation and prostaglandin E2 production in human A549 alveolar type II epithelial cellsQ40137044
Assessment of transcriptional gene activity in situ by application of HOPE-fixed, paraffin-embedded tissuesQ40648998
Effect of proinflammatory cytokines on interleukin-8 mRNA expression and protein production by isolated human alveolar epithelial cells type II in primary cultureQ40836141
Smad7 and Smad6 differentially modulate transforming growth factor beta -induced inhibition of embryonic lung morphogenesisQ41734769
Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humansQ42223174
Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.Q43548312
Maintenance of differentiated function of the surfactant system in human fetal lung type II epithelial cells cultured on plasticQ43734410
Association of pulmonary surfactant protein A (SP-A) gene and respiratory distress syndrome: interaction with SP-B.Q46267050
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)e38369
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleRoflumilast-N-oxide induces surfactant protein expression in human alveolar epithelial cells type II
P478volume7

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cites work (P2860)
Q37077782Aspergillus-associated airway disease, inflammation, and the innate immune response
Q34920790Roflumilast inhibits respiratory syncytial virus infection in human differentiated bronchial epithelial cells
Q38580536Roflumilast: A Review in COPD.

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