LIF-dependent signaling: new pieces in the Lego

scientific article (publication date: March 2012)

LIF-dependent signaling: new pieces in the Lego is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1015066793
P356DOI10.1007/S12015-011-9261-7
P3181OpenCitations bibliographic resource ID4282147
P932PMC publication ID3285761
P698PubMed publication ID21537995
P5875ResearchGate publication ID51093958

P2093author name stringClaire Saucourt
Xavier Gauthereau
Vincent Praloran
Nadine Thézé
Pierre Thiébaud
Hélène Bœuf
Marie-Emmanuelle Mathieu
Virginie Mournetas
P2860cites workSignal Transduction and the Control of Gene ExpressionQ22065837
The ribosomal S6 kinases, cAMP-responsive element-binding, and STAT3 proteins are regulated by different leukemia inhibitory factor signaling pathways in mouse embryonic stem cellsQ74582384
Forced expression of the homeobox-containing gene Pem blocks differentiation of embryonic stem cellsQ77840817
Interleukin-6 family cytokine M17 induces differentiation and nitric oxide response of goldfish (Carassius auratus L.) macrophagesQ79653229
Maintenance of chicken embryonic stem cells in vitroQ79919444
Transcription factors that behave as master regulators during mammalian embryogenesis function as molecular rheostatsQ80946657
Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppressionQ81667319
Klf5 is involved in self-renewal of mouse embryonic stem cellsQ81696401
Bow to your partner for signalingQ81810921
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathwayQ83296436
Hypoxia enhances the generation of induced pluripotent stem cellsQ84487554
Therapeutic potential of LIF in multiple sclerosisQ85093002
Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cellsQ24296832
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identityQ24312181
Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cellsQ24336456
Principles of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cellsQ24534271
The transcriptional foundation of pluripotencyQ24649039
Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factorQ24651524
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinaseQ28138574
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cellsQ28253382
p53 regulates maternal reproduction through LIFQ28259206
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factorQ28269635
The enigma of the role of protein inhibitor of activated STAT3 (PIAS3) in the immune responseQ28274157
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiationQ28294729
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAsQ28297634
Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis.Q28475186
Dissecting self-renewal in stem cells with RNA interferenceQ28506922
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationQ28507317
Dicer is essential for mouse developmentQ28511142
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4Q28512536
Triple knock-out of CNTF, LIF, and CT-1 defines cooperative and distinct roles of these neurotrophic factors for motoneuron maintenance and functionQ28513821
Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathwayQ28566421
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cellsQ28590205
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cellsQ28593119
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencingQ28594776
Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cellsQ28594990
The ground state of embryonic stem cell self-renewalQ29547196
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrityQ29614209
The Ink4/Arf locus is a barrier for iPS cell reprogrammingQ29614210
Derivation of pluripotent epiblast stem cells from mammalian embryosQ29614819
New cell lines from mouse epiblast share defining features with human embryonic stem cellsQ29614820
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewalQ29615487
Linking the p53 tumour suppressor pathway to somatic cell reprogrammingQ29616507
A model system for leukemic transformation of immortalized hemopoietic cells in irradiated recipient miceQ68140722
Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in miceQ68339760
The role of leukemia inhibitory factor in skeletal muscle regenerationQ73405032
Spontaneous and inducible production of leukaemia inhibitory factor by human bone marrow stromal cellsQ73820416
Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factorQ37558911
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell lineQ37625031
Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantationQ37648789
p53 and stem cells: new developments and new concernsQ37671364
Mouse ES cell culture system as a model of developmentQ37690813
Update on the role of leukemia inhibitory factor in assisted reproductionQ37706004
Cytokines, thyroid diseases and thyroid cancer.Q37728313
Extrinsic regulation of pluripotent stem cellsQ37763846
Mesenchymal stem cells: biological properties and clinical applicationsQ37787267
Leukaemia inhibitory factor--an exercise-induced myokine.Q37788653
p53: Guardian of reprogrammingQ37800333
Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specificationQ38349452
Chd1 regulates open chromatin and pluripotency of embryonic stem cellsQ38352404
Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotencyQ38510507
Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in miceQ38647648
Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expressionQ39616419
Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathwayQ39649732
Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimerQ39687424
Involvement of Cx43 phosphorylation in 5'-N-ethylcarboxamide-induced migration and proliferation of mouse embryonic stem cellsQ39727190
JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblastsQ39751478
Leukemia inhibitory factor-dependent increase in myoblast cell number is associated with phosphotidylinositol 3-kinase-mediated inhibition of apoptosis and not mitosis.Q39766688
Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell linesQ39774148
The FunGenES database: a genomics resource for mouse embryonic stem cell differentiationQ39804209
SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathwayQ39822876
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.Q39834991
Interleukin-11 and leukemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation.Q39884319
A role for leukemia inhibitory factor in melanoma-induced bone metastasisQ39924762
Leukemia inhibitory factor as a regulator of steroidogenesis in human NCI-H295R adrenocortical cells.Q39939169
Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factorQ39972513
Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent cultureQ39986443
Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cellsQ40018314
STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cellsQ40024100
Suppression of ES cell differentiation by retinol (vitamin A) via the overexpression of NanogQ40142574
Leukemia inhibitory factor: a newly identified metastatic factor in rhabdomyosarcomasQ40164482
Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells.Q40346958
Functional analysis of the effect of forced activation of STAT3 on M1 mouse leukemia cells.Q40472106
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signallingQ40617733
LIF transduces contradictory signals on capillary outgrowth through induction of stat3 and (P41/43)MAP kinase.Q40843668
Activation of Stat3 by cytokine receptor gp130 ventralizes Xenopus embryos independent of BMP-4.Q40904887
The leukemia inhibitory factor and its receptor.Q40917038
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activationQ41064397
Role of leukemia inhibitory factor during mammalian developmentQ41332042
Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populationsQ41713734
Leukemia inhibitory factor: part of a large ingathering familyQ41722214
Leukaemia inhibitory factor is required for normal inflammatory responses to injury in the peripheral and central nervous systems in vivo and is chemotactic for macrophages in vitroQ41724378
Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chainQ42019529
Suppression of induced pluripotent stem cell generation by the p53-p21 pathwayQ29619160
Src family kinases: regulation of their activities, levels and identification of new pathwaysQ30157744
miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cellsQ30176408
Activity-dependent neuron-glial signaling by ATP and leukemia-inhibitory factor promotes hippocampal glial cell developmentQ30486209
LIF promotes neurogenesis and maintains neural precursors in cell populations derived from spiral ganglion stem cellsQ33302572
Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.Q33337465
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferationQ33382062
Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivativesQ33407022
CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF)Q33411538
N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28bQ33460427
Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long-term repopulating stem cellsQ33497539
Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.Q33896981
Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndromeQ33909639
Characterization of Dicer-deficient murine embryonic stem cells.Q33916756
Leukemia-inhibitory factor-neuroimmune modulator of endocrine functionQ33945364
Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cellsQ33998856
Patient-specific pluripotent stem cells become even more accessibleQ34125353
The Pluripotency Regulator Zic3 Is a Direct Activator of the Nanog Promoter in ESCsQ34140251
Myc represses primitive endoderm differentiation in pluripotent stem cells.Q34198077
PDCD2 is essential for inner cell mass development and embryonic stem cell maintenanceQ34213264
Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factorQ34294780
IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variantsQ34320238
gp130 at the nexus of inflammation, autoimmunity, and cancerQ34378756
Embryo-derived stem cells: of mice and men.Q34425188
Zfx controls the self-renewal of embryonic and hematopoietic stem cells.Q34621247
Identification and characterization of subpopulations in undifferentiated ES cell cultureQ34748697
The fertile field of Drosophila Jak/STAT signallingQ34795769
Klf4 reverts developmentally programmed restriction of ground state pluripotencyQ34947539
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cellsQ34990255
The evolution of signalling pathways in animal developmentQ35037659
The unsolved enigmas of leukemia inhibitory factorQ35046047
Cutaneous leukemia inhibitory factor and its potential role in the development of skin tumorsQ35660976
Zic3 is required for maintenance of pluripotency in embryonic stem cells.Q35723737
New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27.Q35836237
In vitro and in vivo characterization of neural stem cellsQ35891171
LIF: lots of interesting functionsQ36016561
Adult neurogenesis: from precursors to network and physiologyQ36079007
Leukemia inhibitory factor participates in the expansion of neural stem/progenitors after perinatal hypoxia/ischemiaQ36083011
Differentiation inhibiting activity () and mouse developmentQ36191265
Axotrophin and leukaemia inhibitory factor (LIF) in transplantation toleranceQ36251289
Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cellsQ36254804
Regulatory networks in embryo-derived pluripotent stem cellsQ36287880
Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishmentQ36294251
Phylogeny and evolution of class-I helical cytokines.Q36449093
An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells.Q36453935
Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signalingQ36458771
How is pluripotency determined and maintained?Q36704169
Capturing pluripotencyQ36718641
Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression.Q36985192
p53: a new player in reproductionQ37138983
Skeletal muscle stem cellsQ37215650
Role of gap junctions in embryonic and somatic stem cellsQ37243992
Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degenerationQ37309495
Myc-regulated microRNAs attenuate embryonic stem cell differentiation.Q37347322
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cellsQ37393601
Leukemia inhibitory factor regulates the timing of oligodendrocyte development and myelination in the postnatal optic nerveQ37434691
Small molecules for stem cellsQ37481252
Generation of sensory neurons is stimulated by leukemia inhibitory factorQ37489136
The LIF cytokine: towards adulthoodQ37525708
Signaling in adult neurogenesis.Q37540178
Phosphotyrosine Signaling: Evolving a New Cellular Communication SystemQ42413402
lin-Sca-1+ cells and age-dependent changes of their proliferation potential are reliant on mesenchymal stromal cells and are leukemia inhibitory factor dependentQ42442836
Involvement of gp130-associated cytokine signaling in Müller cell activation following optic nerve lesion.Q42466158
Mesenchymal to epithelial conversion in rat metanephros is induced by LIF.Q42614278
Mannose 6-Phosphate/Insulin-like growth factor II receptor mediates internalization and degradation of leukemia inhibitory factor but not signal transductionQ42811788
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewalQ43148740
A novel signaling by vitamin A/retinol promotes self renewal of mouse embryonic stem cells by activating PI3K/Akt signaling pathway via insulin-like growth factor-1 receptorQ43248210
CrxOS maintains the self-renewal capacity of murine embryonic stem cellsQ43267783
Analysis of neuronal and glial phenotypes in brains of mice deficient in leukemia inhibitory factorQ43569348
The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors.Q43906912
Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammationQ43948702
Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferationQ44021414
Molecular cloning and characterisation of a carp (Cyprinus carpio) cytokine-like cDNA that shares sequence similarity with IL-6 subfamily cytokines CNTF, OSM and LIF.Q44288149
Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium.Q44357340
A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary glandQ44480678
Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro.Q44852699
Characterization of a factor produced by human T cell clones exhibiting eosinophil-activating and burst-promoting activitiesQ45257661
Leukemia inhibitory factor promotes neural stem cell self-renewal in the adult brain.Q45959542
Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine.Q46034298
STAT3 induces muscle stem cell differentiation by interaction with myoD.Q46119289
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxiaQ46544733
Leukemia inhibitory factor restores the hypertrophic response to increased loading in the LIF(-/-) mouseQ46576451
Effect of leukemia inhibitory factor on long-term propagation of precursor cells derived from rat forebrain subventricular zone and ventral mesencephalonQ46673298
On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.Q46778710
Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cellsQ46788050
Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio).Q46803714
Identification, cDNA cloning, and mRNA localization of a zebrafish ortholog of leukemia inhibitory factorQ48081471
Leukemia inhibitory factor favours neurogenic differentiation of long-term propagated human midbrain precursor cellsQ48477112
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastomaQ48673261
Leukemia inhibitory factor induces cumulus expansion in immature human and mouse oocytes and improves mouse two-cell rate and delivery rates when it is present during mouse in vitro oocyte maturationQ48766943
Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signalingQ48819254
Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strainsQ48867179
Leukemia inhibitory factor enhances formation of germ cell colonies in neonatal mouse testis culture.Q50712919
WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells.Q50746171
Direct isolation of satellite cells for skeletal muscle regeneration.Q50756094
Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.Q51249622
Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal.Q51921401
A core Klf circuitry regulates self-renewal of embryonic stem cells.Q51964604
Gap junctional intercellular communication is required to maintain embryonic stem cells in a non-differentiated and proliferative state.Q51980016
Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency.Q52051590
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.Q52176534
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.Q52510633
The role of p53 in limiting somatic cell reprogramming.Q53362432
Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIFQ57198135
Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repairQ58425790
Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulationQ59080223
The unusual suspectQ60066491
Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: Injured muscle expresses lif mRNAQ60568036
Leukemia inhibitory factor/human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitorsQ67678011
Stimulation of myoblast proliferation in culture by leukaemia inhibitory factor and other cytokinesQ67988466
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectstem cellQ48196
signal transductionQ828130
Leukemia inhibitory factorQ24723759
P304page(s)1-15
P577publication date2012-03-01
P1433published inStem Cell Reviews and ReportsQ7607285
P1476titleLIF-dependent signaling: new pieces in the Lego
P478volume8