Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein

scientific article (publication date: 2012)

Elicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2012PLoSO...730233D
P356DOI10.1371/JOURNAL.PONE.0030233
P3181OpenCitations bibliographic resource ID4462540
P932PMC publication ID3265465
P698PubMed publication ID22291921
P5875ResearchGate publication ID221793199

P50authorDavid C. MontefioriQ63302725
Andrea CarfìQ88702827
Susan W BarnettQ89214866
Antu K DeyQ89308546
Indresh K SrivastavaQ122828624
Karin HartogQ122828630
P2093author name stringBrian Burke
Loïc Martin
Pascal Kessler
Michael Franti
Ying Lian
Anthony R Geonnotti
Grégoire Martin
Yide Sun
Avishek Nandi
Klara Sirokman
P2860cites workAccess of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1Q24645530
Hyperglycosylated Mutants of Human Immunodeficiency Virus (HIV) Type 1 Monomeric gp120 as Novel Antigens for HIV Vaccine DesignQ24679395
Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding siteQ27316899
Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope GlycoproteinQ27651139
Molecular architecture of native HIV-1 gp120 trimersQ27651385
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120Q27658449
Antibody neutralization and escape by HIV-1Q29547345
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibodyQ29618366
Structure of a V3-containing HIV-1 gp120 coreQ29619014
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesQ29619017
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1Q29619512
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.Q31016954
B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.Q33373664
Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infectionQ33410222
Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance.Q33645053
Characterization of gp120 and its single-chain derivatives, gp120-CD4D12 and gp120-M9: implications for targeting the CD4i epitope in human immunodeficiency virus vaccine designQ33717477
Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.Q33759392
Antibody-mediated protection against mucosal simian-human immunodeficiency virus challenge of macaques immunized with alphavirus replicon particles and boosted with trimeric envelope glycoprotein in MF59 adjuvantQ33877513
Identification and characterization of an immunogenic hybrid epitope formed by both HIV gp120 and human CD4 proteinsQ39668082
Measuring HIV neutralization in a luciferase reporter gene assayQ39914262
Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1.Q40210715
Cross-clade recognition and neutralization by the V3 region from clade C human immunodeficiency virus-1 envelopeQ40281145
The rational design of an AIDS vaccineQ40348550
Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodiesQ40682865
DNA vaccination with the human immunodeficiency virus type 1 SF162DeltaV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8(+) T-cell-depleted rhesus macaquesQ40904272
A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entryQ43506030
Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160.Q44455932
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunizationQ44592013
Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopesQ45052086
Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelopeQ46331384
Immune responses to SIVmne envelope glycoproteins protect macaques from homologous SIV infectionQ67967877
Analysis of the immunogenic properties of a single-chain polypeptide analogue of the HIV-1 gp120?CD4 complex in transgenic mice that produce human immunoglobulinsQ79078538
Comparing antigenicity and immunogenicity of engineered gp120.Q33984309
An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interactionQ34092668
Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaquesQ34154514
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1Q34306804
Purification and characterization of oligomeric envelope glycoprotein from a primary R5 subtype B human immunodeficiency virusQ34332284
A Variable Region 3 (V3) Mutation Determines a Global Neutralization Phenotype and CD4-Independent Infectivity of a Human Immunodeficiency Virus Type 1 Envelope Associated with a Broadly Cross-Reactive, Primary Virus-Neutralizing Antibody ResponseQ34357078
Changes in the immunogenic properties of soluble gp140 human immunodeficiency virus envelope constructs upon partial deletion of the second hypervariable regionQ34471760
A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteersQ34743297
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individualsQ34962766
Antibody responses elicited in macaques immunized with human immunodeficiency virus type 1 (HIV-1) SF162-derived gp140 envelope immunogens: comparison with those elicited during homologous simian/human immunodeficiency virus SHIVSF162P4 and heteroloQ35024202
Stabilization of HIV-1 Envelope in the CD4-bound Conformation through Specific Cross-linking of a CD4 MimeticQ35065249
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infectionQ35857268
Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogensQ36141515
Antigenic conservation and immunogenicity of the HIV coreceptor binding siteQ36403587
N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virusQ36565090
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 bindingQ36649958
Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolatesQ36656036
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor bindingQ36795606
Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivityQ36797873
Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibodyQ36821885
Roles of HIV-1 Env variable regions in viral neutralization and vaccine developmentQ37017791
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individualsQ37033400
Characterizing anti-HIV monoclonal antibodies and immune sera by defining the mechanism of neutralization.Q37072702
A simple one-step method for the preparation of HIV-1 envelope glycoprotein immunogens based on a CD4 mimic peptideQ37102810
Toward an AIDS vaccineQ37158259
Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challengeQ37297052
Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donorsQ37333772
Immunogenicity of HIV-1 envelope glycoprotein oligomersQ37667740
Neutralizing antibody responses to subtype B and C adjuvanted HIV envelope protein vaccination in rabbitsQ38356290
Priming B cell-mediated anti-HIV envelope responses by vaccination allows for the long-term control of infection in macaques exposed to a R5-tropic SHIV.Q38924919
Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 IsolateQ39484956
CD4 mimetic miniproteins: potent anti-HIV compounds with promising activity as microbicidesQ39550847
The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable regionQ39602963
Characterization of immune responses elicited in macaques immunized sequentially with chimeric VEE/SIN alphavirus replicon particles expressing SIVGag and/or HIVEnv and with recombinant HIVgp140Env proteinQ39608920
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)e30233
P577publication date2012-01-01
P1433published inPLOS OneQ564954
P1476titleElicitation of neutralizing antibodies directed against CD4-induced epitope(s) using a CD4 mimetic cross-linked to a HIV-1 envelope glycoprotein
P478volume7

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cites work (P2860)
Q35058860Allosteric induction of the CD4-bound conformation of HIV-1 Gp120.
Q38793711Crosslinking of a CD4 Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques
Q40471543Env-2dCD4 S60C complexes act as super immunogens and elicit potent, broadly neutralizing antibodies against clinically relevant human immunodeficiency virus type 1 (HIV-1).
Q28552786Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa
Q35032794HIV-1 CD4-induced (CD4i) gp120 epitope vaccines promote B and T-cell responses that contribute to reduced viral loads in rhesus macaques
Q27679031Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites
Q47566053Identification of novel structural determinants in MW965 Env that regulate the neutralization phenotype and conformational masking potential of primary HIV-1 isolates
Q27678341Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein
Q28534454Stabilizing exposure of conserved epitopes by structure guided insertion of disulfide bond in HIV-1 envelope glycoprotein
Q36559665Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120